دورية أكاديمية
Repurposing Proton Beam Therapy through Novel Insights into Tumour Radioresistance.
| العنوان: | Repurposing Proton Beam Therapy through Novel Insights into Tumour Radioresistance. |
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| المؤلفون: | Chua KLM; Oncology Academic Clinical Programme, Duke-NUS Medical School, Singapore; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore., Chu PL; Oncology Academic Clinical Programme, Duke-NUS Medical School, Singapore., Tng DJH; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore., Soo KC; Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Division of Surgical Oncology, National Cancer Centre Singapore, Singapore., Chua MLK; Oncology Academic Clinical Programme, Duke-NUS Medical School, Singapore; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore; Division of Medical Sciences, National Cancer Centre Singapore, Singapore. Electronic address: Melvin.chua.l.k@singhealth.com.sg. |
| المصدر: | Clinical oncology (Royal College of Radiologists (Great Britain)) [Clin Oncol (R Coll Radiol)] 2021 Nov; Vol. 33 (11), pp. e469-e481. Date of Electronic Publication: 2021 Sep 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: England NLM ID: 9002902 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-2981 (Electronic) Linking ISSN: 09366555 NLM ISO Abbreviation: Clin Oncol (R Coll Radiol) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : London : W.B. Saunders Original Publication: [London, UK] : Springer International, [c1989- |
| مواضيع طبية MeSH: | Neoplasms*/radiotherapy , Proton Therapy* , Radiation Oncology*, Humans ; Patient Selection ; Tumor Microenvironment |
| مستخلص: | Despite improvements in radiotherapy, radioresistance remains an important clinical challenge. Radioresistance can be mediated through enhanced DNA damage response mechanisms within the tumour or through selective pressures exerted by the tumour microenvironment (TME). The effects of the TME have in recent times gained increased attention, in part due to the success of immune modulating strategies, but also through improved understanding of the downstream effects of hypoxia and dysregulated wound healing processes on mediating radioresistance. Although we have a better appreciation of these molecular mechanisms, efforts to address them through novel combination approaches have been scarce, owing to limitations of photon therapy and concerns over toxicity. At the same time, proton beam therapy (PBT) represents an advancement in radiotherapy technologies. However, early clinical results have been mixed and the clinical strategies around optimal use and patient selection for PBT remain unclear. Here we highlight the role that PBT can play in addressing radioresistance, through better patient selection, and by providing an improved toxicity profile for integration with novel agents. We will also describe the developments around FLASH PBT. Through close examination of its normal tissue-sparing effects, we will highlight how FLASH PBT can facilitate combination strategies to tackle radioresistance by further improving toxicity profiles and by directly mediating the mechanisms of radioresistance. (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: FLASH; proton beam therapy; radioresistance; radiotherapy; ultra-high dose rate |
| تواريخ الأحداث: | Date Created: 20210912 Date Completed: 20211125 Latest Revision: 20211125 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.clon.2021.08.013 |
| PMID: | 34509347 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1433-2981 |
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| DOI: | 10.1016/j.clon.2021.08.013 |