دورية أكاديمية
أعرض في EDS

Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells.

التفاصيل البيبلوغرافية
العنوان: Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells.
المؤلفون: Oulee A; Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States., Ma F; Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States.; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States., Teles RMB; Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States., de Andrade Silva BJ; Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States., Pellegrini M; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States., Klechevsky E; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States., Harman AN; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health Sydney, The University of Sydney, Westmead, NSW, Australia., Rhodes JW; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health Sydney, The University of Sydney, Westmead, NSW, Australia., Modlin RL; Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States.
المصدر: Frontiers in immunology [Front Immunol] 2021 Aug 26; Vol. 12, pp. 695373. Date of Electronic Publication: 2021 Aug 26 (Print Publication: 2021).
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Transcriptome*, Antimicrobial Peptides/*genetics , Epidermis/*metabolism , Langerhans Cells/*metabolism , Staphylococcal Skin Infections/*genetics , Staphylococcus aureus/*pathogenicity, Cells, Cultured ; Databases, Genetic ; Epidermis/immunology ; Epidermis/microbiology ; Gene Expression Profiling ; Host-Pathogen Interactions ; Humans ; Langerhans Cells/immunology ; Langerhans Cells/microbiology ; Staphylococcal Skin Infections/immunology ; Staphylococcal Skin Infections/metabolism ; Staphylococcal Skin Infections/microbiology ; Staphylococcus aureus/immunology
مستخلص: Langerhans cells (LCs) reside in the epidermis where they are poised to mount an antimicrobial response against microbial pathogens invading from the outside environment. To elucidate potential pathways by which LCs contribute to host defense, we mined published LC transcriptomes deposited in GEO and the scientific literature for genes that participate in antimicrobial responses. Overall, we identified 31 genes in LCs that encode proteins that contribute to antimicrobial activity, ten of which were cross-validated in at least two separate experiments. Seven of these ten antimicrobial genes encode chemokines, CCL1, CCL17, CCL19, CCL2, CCL22, CXCL14 and CXCL2 , which mediate both antimicrobial and inflammatory responses. Of these, CCL22 was detected in seven of nine transcriptomes and by PCR in cultured LCs. Overall, the antimicrobial genes identified in LCs encode proteins with broad antibacterial activity, including against Staphylococcus aureus , which is the leading cause of skin infections. Thus, this study illustrates that LCs, consistent with their anatomical location, are programmed to mount an antimicrobial response against invading pathogens in skin.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Oulee, Ma, Teles, de Andrade Silva, Pellegrini, Klechevsky, Harman, Rhodes and Modlin.)
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معلومات مُعتمدة: R01 AR075959 United States AR NIAMS NIH HHS; R01 CA245277 United States CA NCI NIH HHS; R01 AR073252 United States AR NIAMS NIH HHS; R01 AR040312 United States AR NIAMS NIH HHS; R21 EB024767 United States EB NIBIB NIH HHS; P50 AR080594 United States AR NIAMS NIH HHS; R01 AI022553 United States AI NIAID NIH HHS; R01 AR074302 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: Langerhans cells; antimicrobial peptides; bioinformatics; dendritic cells; immunity; skin; transcriptome
المشرفين على المادة: 0 (Antimicrobial Peptides)
تواريخ الأحداث: Date Created: 20210913 Date Completed: 20211213 Latest Revision: 20230701
رمز التحديث: 20230701
مُعرف محوري في PubMed: PMC8426439
DOI: 10.3389/fimmu.2021.695373
PMID: 34512625
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2021.695373