Anthelmintic activity of pomegranate peel extract (Punica granatum) and synthetic anthelmintics against gastrointestinal nematodes in cattle, sheep, goats, and buffalos: in vivo study.

التفاصيل البيبلوغرافية
العنوان:	Anthelmintic activity of pomegranate peel extract (Punica granatum) and synthetic anthelmintics against gastrointestinal nematodes in cattle, sheep, goats, and buffalos: in vivo study.
المؤلفون:	Kaiaty AM; Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt.; General Organization for Veterinary Services, Giza, Egypt., Salib FA; Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt., El-Gameel SM; Parasitology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt., Hussien AM; Toxicology & Forensic Medicine Department, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt., Kamel MS; Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt. M_salah@cu.edu.eg.
المصدر:	Parasitology research [Parasitol Res] 2021 Nov; Vol. 120 (11), pp. 3883-3893. Date of Electronic Publication: 2021 Sep 13.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin : Springer International, c1987-
مواضيع طبية MeSH:	Anthelmintics/therapeutic use , Nematoda , Pomegranate* , Sheep Diseases*/drug therapy, Animals ; Buffaloes ; Cattle ; Feces ; Goats ; Parasite Egg Count ; Plant Extracts/pharmacology ; Sheep
مستخلص:	Parasitic gastroenteritis (PGE) is one of the most important parasitic diseases that causes economic losses and health problems in ruminants. PGE causes a drop in milk, meat, and wool production in addition to decreasing animal fertility and sometimes leading to animal death. Conventional anthelmintics used for animal treatment are expensive, especially for farmers in developing countries. Moreover, the concern of anthelmintic resistance to these synthetic drugs is rising. Therefore, this study aimed to evaluate the anthelmintic activity of plant extract pomegranate (Punica granatum L) peel extract (PPE) against PGE infestations among ruminants. A total of 120 ruminants of different species (20 cattle, 12 buffalos, 68 sheep, and 20 goats) were examined for PGE eggs in their fecal samples. The animals under experiment were divided into four groups: the first group (negative control) was not given any drugs, the second group was given ivermectin (0.5 ml/25 kg bwt) (positive control 1), the third group was given albendazole (2.5 mg active principle/kg bwt) (positive control 2), and the fourth group was given PPE (200 mg/kg bwt). Fecal egg count (FEC) was performed on day 0 prior to the 1st dose of treatment. On day 15, an additional treatment (with the same doses) was administered and FEC was performed on days 7 and 21. Our results showed that on the 7th day of the experiment, there was an increase in FEC in the negative control group by 5%, while in the second, third, and fourth groups, there was a decrease in FEC with 95%, 90%, and 85% respectively. On the 21st day (7 days from the second dose), there was an increase in FEC in the control group by a 10% and 100% reduction in FEC in both the second and third groups. While in the fourth group, there was a decrease in FEC by 97%. In conclusion, PPE could be used as a safe, cheap, and effective natural anthelmintic against PGE. (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة:	Keywords: Albendazole; Anthelmintics; Ivermectin; Parasitic gastroenteritis; Plant extract; Pomegranate peel extract; Punica granatum; Ruminants
المشرفين على المادة:	0 (Anthelmintics) 0 (Plant Extracts)
تواريخ الأحداث:	Date Created: 20210913 Date Completed: 20211125 Latest Revision: 20211125
رمز التحديث:	20221213
DOI:	10.1007/s00436-021-07311-8
PMID:	34515863
قاعدة البيانات:	MEDLINE

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تدمد:	1432-1955
DOI:	10.1007/s00436-021-07311-8