دورية أكاديمية
Anthelmintic activity of pomegranate peel extract (Punica granatum) and synthetic anthelmintics against gastrointestinal nematodes in cattle, sheep, goats, and buffalos: in vivo study.
العنوان: | Anthelmintic activity of pomegranate peel extract (Punica granatum) and synthetic anthelmintics against gastrointestinal nematodes in cattle, sheep, goats, and buffalos: in vivo study. |
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المؤلفون: | Kaiaty AM; Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt.; General Organization for Veterinary Services, Giza, Egypt., Salib FA; Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt., El-Gameel SM; Parasitology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt., Hussien AM; Toxicology & Forensic Medicine Department, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt., Kamel MS; Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt. M_salah@cu.edu.eg. |
المصدر: | Parasitology research [Parasitol Res] 2021 Nov; Vol. 120 (11), pp. 3883-3893. Date of Electronic Publication: 2021 Sep 13. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1987- |
مواضيع طبية MeSH: | Anthelmintics*/therapeutic use , Nematoda* , Pomegranate* , Sheep Diseases*/drug therapy, Animals ; Buffaloes ; Cattle ; Feces ; Goats ; Parasite Egg Count ; Plant Extracts/pharmacology ; Sheep |
مستخلص: | Parasitic gastroenteritis (PGE) is one of the most important parasitic diseases that causes economic losses and health problems in ruminants. PGE causes a drop in milk, meat, and wool production in addition to decreasing animal fertility and sometimes leading to animal death. Conventional anthelmintics used for animal treatment are expensive, especially for farmers in developing countries. Moreover, the concern of anthelmintic resistance to these synthetic drugs is rising. Therefore, this study aimed to evaluate the anthelmintic activity of plant extract pomegranate (Punica granatum L) peel extract (PPE) against PGE infestations among ruminants. A total of 120 ruminants of different species (20 cattle, 12 buffalos, 68 sheep, and 20 goats) were examined for PGE eggs in their fecal samples. The animals under experiment were divided into four groups: the first group (negative control) was not given any drugs, the second group was given ivermectin (0.5 ml/25 kg bwt) (positive control 1), the third group was given albendazole (2.5 mg active principle/kg bwt) (positive control 2), and the fourth group was given PPE (200 mg/kg bwt). Fecal egg count (FEC) was performed on day 0 prior to the 1st dose of treatment. On day 15, an additional treatment (with the same doses) was administered and FEC was performed on days 7 and 21. Our results showed that on the 7th day of the experiment, there was an increase in FEC in the negative control group by 5%, while in the second, third, and fourth groups, there was a decrease in FEC with 95%, 90%, and 85% respectively. On the 21st day (7 days from the second dose), there was an increase in FEC in the control group by a 10% and 100% reduction in FEC in both the second and third groups. While in the fourth group, there was a decrease in FEC by 97%. In conclusion, PPE could be used as a safe, cheap, and effective natural anthelmintic against PGE. (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
References: | Abdel Moneim AE (2012) Evaluating the potential role of pomegranate peel in aluminum-induced oxidative stress and histopathological alterations in brain of female rats. Biol Trace Elem Res 150:328–336. https://doi.org/10.1007/s12011-012-9498-2. (PMID: 10.1007/s12011-012-9498-222945624) Abdel-Ghaffar F, Semmler M, Al-Rasheid KAS, Strassen B, Fischer K, Aksu G, Klimpel S, Mehlhorn H (2010) The effects of different plant extracts on intestinal cestodes and on trematodes. Parasitol Res 108:979–984. https://doi.org/10.1007/s00436-010-2167-5. (PMID: 10.1007/s00436-010-2167-521107861) Abdel-Hafeez EH, Ahmed AK, Abdellatif MZ, Kamal AM, Toni ND (2016) The efficacy of pomegranate (Punica granatum) peel extract on experimentally infected rats with blastocystis spp. Journal of Ancient Diseases & Preventive Remedies 4. https://doi.org/10.4172/2329-8731.1000131. Abdollahzadeh SH, Mashouf RY, Mortazavi H, Moghaddam MH, Roozbahani N, Vahedi M (2011) Antibacterial and antifungal activities of Punica granatum peel extracts against oral pathogens. Journal of Dentistry (tehran, Iran) 8:1. Aboelsoued D, Abo-Aziza FA, Mahmoud MH, Abdel Megeed KN, Abu El Ezz NMT, Abu-Salem FM (2019) Anticryptosporidial effect of pomegranate peels water extract in experimentally infected mice with special reference to some biochemical parameters and antioxidant activity. J Parasit Dis 43:215–228. https://doi.org/10.1007/s12639-018-01078-z. (PMID: 10.1007/s12639-018-01078-z312633266570737) Aggarwal R, Kaur K, Suri M, Bagai U (2016) Anthelmintic potential of Calotropis procera, Azadirachta indica and Punica granatum against Gastrothylax indicus. J Parasit Dis 40:1230–1238. https://doi.org/10.1007/s12639-015-0658-0. (PMID: 10.1007/s12639-015-0658-027876922) Akhtar M, Iqbal Z, Khan M, Lateef M (2000) Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo-Pakistan subcontinent. Small Rumin Res 38:99–107. https://doi.org/10.1016/s0921-4488(00)00163-2. (PMID: 10.1016/s0921-4488(00)00163-2) Al-Mathal EM, Alsalem AM (2012) Pomegranate (Punica granatum) peel is effective in a murine model of experimental Cryptosporidium parvum. Exp Parasitol 131:350–357. https://doi.org/10.1016/j.exppara.2012.04.021. (PMID: 10.1016/j.exppara.2012.04.02122580265) Amelia M, Jasaputra DK, Tjokropranoto R, Kedokteran F, Kristen U (2017a) Effects of pomegranate peel (Punica granatum L.) extract as an anthelmintic Khasiat Ekstrak Kulit Buah Delima (Punica granatum L.) Sebagai Antelmintik 1:409–416. Amelia M, Jasaputra DK, Tjokropranoto R (2017b) Effects of pomegranate peel (Punica granatum L.) extract as an anthelmintic. Journal Of Medicine & Health 1. https://doi.org/10.28932/jmh.v1i5.537. Bassiri-Jahromi S (2018) Punica granatum (Pomegranate) activity in health promotion and cancer prevention. Oncol Rev 12:345. https://doi.org/10.4081/oncol.2018.345. (PMID: 10.4081/oncol.2018.345294411505806496) Bassiri-Jahromi S, Pourshafie MR, Ardakani EM, Ehsani AH, Doostkam A, Katirae F, Mostafavi E (2018) In vivo comparative evaluation of the pomegranate (Punica granatum) peel extract as an alternative agent to nystatin against oral candidiasis. Iranian Journal of Medical Sciences 43:296–304. Calzada F, Yépez-Mulia L, Aguilar A (2006) In vitro susceptibility of Entamoeba histolytica and Giardia lamblia to plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders. J Ethnopharmacol 108:367–370. https://doi.org/10.1016/j.jep.2006.05.025. (PMID: 10.1016/j.jep.2006.05.02516846708) Castagna F, Britti D, Oliverio M, Bosco A, Bonacci S, Iriti G, Ragusa M, Musolino V, Rinaldi L, Palma E, Musella V (2020) In vitro anthelminthic efficacy of aqueous pomegranate Punica granatum L extracts against gastrointestinal nematodes of sheep. Pathogens 9(12):1063. https://doi.org/10.3390/pathogens9121063. (PMID: 10.3390/pathogens91210637766728) Coles GC, Jackson F, Pomroy WE, Prichard RK, von Samson-Himmelstjerna G, Silvestre A, Taylor MA, Vercruysse J (2006) The detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol 136:167–185. https://doi.org/10.1016/j.vetpar.2005.11.019. (PMID: 10.1016/j.vetpar.2005.11.01916427201) Correddu F, Lunesu MF, Buffa G, Atzori AS, Nudda A, Battacone G, Pulina G (2020) Can agro-industrial by-products rich in polyphenols be advantageously used in the feeding and nutrition of dairy small ruminants? Animals 10:1–25. https://doi.org/10.3390/ani10010131. (PMID: 10.3390/ani10010131) Das S, Barman S (2012) Antidiabetic and antihyperlipidemic effects of ethanolic extract of leaves of Punica granatum in alloxan-induced non-insulin-dependent diabetes mellitus. Indian J pharmacol 44:219. (PMID: 10.4103/0253-7613.93853) Dell’Agli M, Galli GV, Corbett Y, Taramelli D, Lucantoni L, Habluetzel A, Maschi O, Caruso D, Giavarini F, Romeo S, Bhattacharya D, Bosisio E (2009) Antiplasmodial activity of Punica granatum L. fruit rind. J Ethnopharmacol 125:279–285. https://doi.org/10.1016/j.jep.2009.06.025. (PMID: 10.1016/j.jep.2009.06.02519577622) Dipak G, Axay P, Manodeep C, Jagdish KV (2012) Phytochemical and pharmacological profile of Punica granatum:65–68. Dkhil MA, Al-Quraishy S, Abdel Moneim AE, Delic D (2012) Protective effect of Azadirachta indica extract against Eimeria papillata-induced coccidiosis. Parasitol Res 112:101–106. https://doi.org/10.1007/s00436-012-3109-1. (PMID: 10.1007/s00436-012-3109-122972359) Doostkam A, Bassiri-Jahromi S, Iravani K (2020) Punica granatum with multiple effects in chronic diseases. Int JFruit Sci 20:471–494. https://doi.org/10.1080/15538362.2019.1653809. (PMID: 10.1080/15538362.2019.1653809) El-Bahy NM, Abdelaziz AR, Khalafalla RE (2019) In-vitro evaluation of Nigella sativa and Punica granatum effect on protoscolices of hydatid cysts. Rev Bras Parasitol Vet 28:210–214. https://doi.org/10.1590/S1984-29612019019. (PMID: 10.1590/S1984-2961201901931215605) Eldiasty J, Hassan M, Kamel O (2014) Evaluation of some agricultural waste extracts against mosquito larvae and some types of microorganisms as insecticidal and antibiotic agents Egyptian Academic Journal of Biological Sciences G. Microbiol 6:1–16. https://doi.org/10.21608/eajbsg.2014.16625. (PMID: 10.21608/eajbsg.2014.16625) Emam AM, Ahmed MAM, Tammam MAA, Hala A., Hanaa (2015) Isolation and structural identification of compounds with antioxidant, nematicidal and fungicidal activities from Punica granatum L. var. nana, vol 6. Value of present diagnostic methods for gastrointestinal nematode infections in ruminantsm Parasitol 120:S109–S119. Fernandes RM, Rodrigues, Maria de Lurdes de Azevedo, Borba HR, Fernandes, Maria Zenaide de Lima Chagas Moreno, Amorim A de (2004) Ausência da atividade anti-helmíntica de plantas em frangos de corte naturalmente infectados com Heterakis gallinarum (Schranck,1788) Madsen,1949. Ciência Rural 34:1629–1632. https://doi.org/10.1590/s0103-84782004000500050. Fourati M, Smaoui S, Hlima HB, Elhadef K, Braïek OB, Ennouri K, Mtibaa AC, Mellouli L (2020) Bioactive compounds and pharmacological potential of pomegranate (Punica granatum) seeds—a review. Plant Foods Hum Nutr 75:477–486. https://doi.org/10.1007/s11130-020-00863-7. (PMID: 10.1007/s11130-020-00863-733040298) Hajoori MU, Naik M, Naik K, Desai S (2014) Evaluation of antimicrobial activity of Punica granatum peel extracts using different solvent system. International Journal of Pharmacological screening methods:26–31. Hoste H, Torres-Acosta J (2011) Non chemical control of helminths in ruminants: adapting solutions for changing worms in a changing world. Vet Parasitol 180:144–154. https://doi.org/10.1016/j.vetpar.2011.05.035. (PMID: 10.1016/j.vetpar.2011.05.03521705144) Hoste H, Torres-Acosta JF, Paolini V, Aguilar-Caballero A, Etter E, Lefrileux Y, Chartier C, Broqua C (2005) Interactions between nutrition and gastrointestinal infections with parasitic nematodes in goats. Small Rumin Res 60:141–151. https://doi.org/10.1016/j.smallrumres.2005.06.008. (PMID: 10.1016/j.smallrumres.2005.06.008) Jayaprakash A (2007) A review on phytochemicals, antioxidant and antimicrobial. J Acad Ind Res 5:132–138. Jebanesan A, Baranitharan M, Kovendan K, Avery PB (2020) Impact of Punica granatum-based green larvicide on the predation rate of Polypedates cruciger for the control of mosquito vectors, Anopheles stephensi and Culex quinquefasciatus (Diptera: Culicidae). Int J Trop Insect Sci. https://doi.org/10.1007/s42690-020-00293-7. (PMID: 10.1007/s42690-020-00293-7) Kanojiya D, Shanker D, Sudan V, Jaiswal AK, Parashar R (2014) In vitro and in vivo efficacy of extracts of leaves of Eucalyptus globulus on ovine gastrointestinal nematodes. Parasitol Res 114:141–148. https://doi.org/10.1007/s00436-014-4169-1. (PMID: 10.1007/s00436-014-4169-125300421) Khalid SMA, Amin MR, Mostofa M, Hossain MJ, Azad MAK (2004) Effect of vermic against gastrointestinal nematodiasis in sheep. J Biol Sci 4(6):720–724. https://doi.org/10.3923/jbs.2004.720.724. (PMID: 10.3923/jbs.2004.720.724) Korayem AM, Hasabo SA, Ameen HH (1993) Effects and mode of action of some plant extracts on certain plant parasitic nematodes. Anzeiger Für Schädlingskunde Pflanzenschutz Umweltschutz 66:32–36. https://doi.org/10.1007/bf01909140. (PMID: 10.1007/bf01909140) Labsi M, Soufli I, Khelifi L, Amir ZC, Touil-Boukoffa C (2019) A preventive effect of the combination of albendazole and pomegranate peel aqueous extract treatment in cystic echinococcosis mice model: an alternative approach. Acta Trop 197:105050. https://doi.org/10.1016/j.actatropica.2019.105050. (PMID: 10.1016/j.actatropica.2019.105050) Levine ND, Soulsby EJL, Monnig HO (1969) Helminths, arthropods and protozoa of domesticated animals. Trans Am Microsc Soc 88:319. https://doi.org/10.2307/3224517. (PMID: 10.2307/3224517) Marques S, Oliveira CNF de, Oliveira RN de, Ferraz T, Garcia Rehder VL (2012) The use of Brazilian medicinal plants to combat Schistosoma mansoni. Mavrot F, Hertzberg H, Torgerson P (2015) Effect of gastro-intestinal nematode infection on sheep performance: a systematic review and meta-analysis. Parasit Vectors 8:557. https://doi.org/10.1186/s13071-015-1164-z. (PMID: 10.1186/s13071-015-1164-z264968934619485) Metwaly MS, Dkhil MA, Al-Quraishy S (2012) The potential role of Phoenix dactylifera on Eimeria papillata-induced infection in mice. Parasitol Res 111:681–687. https://doi.org/10.1007/s00436-012-2887-9. (PMID: 10.1007/s00436-012-2887-922411635) de Moraes J (2015) Natural products with antischistosomal activity. Future Med Chem 7:801–820. https://doi.org/10.4155/fmc.15.23. (PMID: 10.4155/fmc.15.2325996071) de Moraes J, Nascimento C, Yamaguchi LF, Kato MJ, Nakano E (2012) Schistosoma mansoni: in vitro schistosomicidal activity and tegumental alterations induced by piplartine on schistosomula. Exp Parasitol 132:222–227. https://doi.org/10.1016/j.exppara.2012.07.004. (PMID: 10.1016/j.exppara.2012.07.00422796749) Musella V, Catelan D, Rinaldi L, Lagazio C, Cringoli G, Biggeri A (2011) Covariate selection in multivariate spatial analysis of ovine parasitic infection. Prev Vet Med 99:69–77. https://doi.org/10.1016/j.prevetmed.2010.11.012. (PMID: 10.1016/j.prevetmed.2010.11.01221167615) Niezen JH, Waghorn TS, Charleston WAG, Waghorn GC (1995) Growth and gastrointestinal nematode parasitism in lambs grazing either lucerne (Medicago sativa) or sulla (Hedysarum coronarium) which contains condensed tannins. J Agric Sci 125:281–289. https://doi.org/10.1017/s0021859600084422. (PMID: 10.1017/s0021859600084422) Pilo C, Altea A, Pirino S, Nicolussi P, Varcasia A, Genchi M, Scala A (2012) Strongylus vulgaris (Looss, 1900) in horses in Italy: is it still a problem? Vet Parasitol 184(2–4):161–167. (PMID: 10.1016/j.vetpar.2011.09.016) Poli CH, Thornton-Kurth KJ, Legako JF, Bremm C, Hampel VS, Hall J, Ipharraguerre IR, Villalba JJ (2018) Self-selection of plant bioactive compounds by sheep in response to challenge infection with Haemonchus contortus. Physiol Behav 194:302–310. https://doi.org/10.1016/j.physbeh.2018.06.013. (PMID: 10.1016/j.physbeh.2018.06.01329906471) Pradhan KD, Thakur DK, Sudhan NA (1993) Therapeutic efficacy of Punica granatum and Cucurbita maxima against clinical cases of nematodiasis in calves. Indian Journal of Indigenous Medicines. Prakash CVS, Prakash I (2011) Bioactive chemical constituents from pomegranate (Punica granatum) juice, seed and peel-a review. Int J Res Chem Environ:1–18. Rock A, Bowden S, Cousquer G (2007) Veterinary pharmacology: a practical guide for the veterinary nurse / by Amanda Rock; with contributions by Sally Bowden, Glen Cousquer. Butterworth-Heinemann/Elsevier, Edinburgh. Rufeng Wang, Yi @bullet, Ding, bullet Ruining Liu, Du (2010) Pomegranate: constituents, bioactivities and pharmacokinetics, vol 4. Sargison ND (2012) Pharmaceutical treatments of gastrointestinal nematode infections of sheep—future of anthelmintic drugs. Vet Parasitol 189:79–84. https://doi.org/10.1016/j.vetpar.2012.03.035. (PMID: 10.1016/j.vetpar.2012.03.03522497871) Soetan KO, Lasisi OT, Agboluaje AK (2011) Comparative assessment of in-vitro anthelmintic effects of the aqueous extracts of the seeds and leaves of the African locust bean (Parkia biglobosa) on bovine … 5:109–112. Steinmann P, Utzinger J, Du Z, Jiang J, Chen J, Hattendorf J, Zhou H, Zhou X (2011) Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS One6(9). https://doi.org/10.1371/journal.pone.0025003 . Tantry MA, Tantray MA, Akbar S, Khan R, Tariq KA, Shawl AS (2009) Humarain: a new dimeric gallic acid glycoside from Punica granatum L. bark. Fitoterapia 80:223–225. https://doi.org/10.1016/j.fitote.2009.01.013. (PMID: 10.1016/j.fitote.2009.01.01319535016) Tonuci LRS, de Melo NI, Dias HJ, Wakabayashi KAL, Aguiar GP, Aguiar DP, Mantovani ALL, Ramos RC, Groppo M, Rodrigues V, Veneziani RCS, Cunha WR, Da Silva Filho AA, Magalhães LG, Crotti AEM (2012) In vitro schistosomicidal effects of the essential oil of Tagetes erecta. Rev Bras 22:88–93. https://doi.org/10.1590/s0102-695x2011005000202. (PMID: 10.1590/s0102-695x2011005000202) Van Wyk JA, Mayhew E (2013) Morphological identification of parasitic nematode infective larvae of small ruminants and cattle: a practical lab guide. Onderstepoort J Vet Res 80(1):539–553. (PMID: 23718204) Vidal A, Fallarero A, Peña BR, Medina ME, Gra B, Rivera F, Gutierrez Y, Vuorela PM (2003) Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. J Ethnopharmacol 89:295–300. https://doi.org/10.1016/j.jep.2003.09.001. (PMID: 10.1016/j.jep.2003.09.00114611895) Yones DA, Badary DM, Sayed HMB, Bayoumi SAH, Khalifa AA, El-Moghazy AM (2016) Comparative evaluation of anthelmintic activity of edible and ornamental pomegranate ethanolic extracts against Schistosoma mansoni. Biomed Res Int 2016:2872708. https://doi.org/10.1155/2016/2872708. (PMID: 10.1155/2016/2872708279904255136632) Zajíčková M, Nguyen LT, Skálová L, Raisová Stuchlíková L, Matoušková P (2020) Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes. Drug Discovery Today 25:430–437. https://doi.org/10.1016/j.drudis.2019.12.007. (PMID: 10.1016/j.drudis.2019.12.00731883953) Zhao SS, Ma DX, Zhu Y, Zhao JH, Zhang Y, Chen JQ, Sheng ZL (2018) Antidiarrheal effect of bioactivity-guided fractions and bioactive components of pomegranate (Punica granatum L.) peels. Neurogastroenterol Motil 30:1–10. https://doi.org/10.1111/nmo.13364. (PMID: 10.1111/nmo.13364) |
فهرسة مساهمة: | Keywords: Albendazole; Anthelmintics; Ivermectin; Parasitic gastroenteritis; Plant extract; Pomegranate peel extract; Punica granatum; Ruminants |
المشرفين على المادة: | 0 (Anthelmintics) 0 (Plant Extracts) |
تواريخ الأحداث: | Date Created: 20210913 Date Completed: 20211125 Latest Revision: 20211125 |
رمز التحديث: | 20221213 |
DOI: | 10.1007/s00436-021-07311-8 |
PMID: | 34515863 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-1955 |
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DOI: | 10.1007/s00436-021-07311-8 |