Mutagenicity Profile Induced by UVB Light in Human Xeroderma Pigmentosum Group C Cells.

التفاصيل البيبلوغرافية
العنوان:	Mutagenicity Profile Induced by UVB Light in Human Xeroderma Pigmentosum Group C Cells.
المؤلفون:	Quintero-Ruiz N; Laboratorio de reparo de DNA, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Corradi C; Laboratorio de reparo de DNA, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Moreno NC; Laboratorio de reparo de DNA, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil., de Souza TA; Laboratorio de reparo de DNA, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.; Tau GC Bioinformatics, São Paulo, Brazil., Pereira Castro L; Laboratorio de reparo de DNA, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Rocha CRR; Laboratorio de reparo de DNA, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.; Drug resistance and mutagenesis Laboratory, Departmento de Oncologia Clínica e Experimental, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil., Menck CFM; Laboratorio de reparo de DNA, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
المصدر:	Photochemistry and photobiology [Photochem Photobiol] 2022 May; Vol. 98 (3), pp. 713-731. Date of Electronic Publication: 2021 Sep 30.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: American Society for Photobiology Country of Publication: United States NLM ID: 0376425 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-1097 (Electronic) Linking ISSN: 00318655 NLM ISO Abbreviation: Photochem Photobiol Subsets: MEDLINE
أسماء مطبوعة:	Publication: <2004->: Lawrence KS : American Society for Photobiology Original Publication: Augusta, GA: American Society for Photobiology, <1996->
مواضيع طبية MeSH:	Skin Neoplasms/genetics , Xeroderma Pigmentosum/complications , Xeroderma Pigmentosum*/genetics, DNA Damage ; DNA Repair ; Humans ; Mutagenesis ; Mutagens ; Mutation ; Ultraviolet Rays/adverse effects
مستخلص:	Nucleotide excision repair (NER) is one of the main pathways for genome protection against structural DNA damage caused by sunlight, which in turn is extensively related to skin cancer development. The mutation spectra induced by UVB were investigated by whole-exome sequencing of randomly selected clones of NER-proficient and XP-C-deficient human skin fibroblasts. As a model, a cell line unable to recognize and remove lesions (XP-C) was used and compared to the complemented isogenic control (COMP). As expected, a significant increase of mutagenesis was observed in irradiated XP-C cells, mainly C>T transitions, but also CC>TT and C>A base substitutions. Remarkably, the C>T mutations occur mainly at the second base of dipyrimidine sites in pyrimidine-rich sequence contexts, with 5'TC sequence the most mutated. Although T>N mutations were also significantly increased, they were not directly related to pyrimidine dimers. Moreover, the large-scale study of a single UVB irradiation on XP-C cells allowed recovering the typical mutation spectrum found in human skin cancer tumors. Eventually, the data may be used for comparison with the mutational profiles of skin tumors obtained from XP-C patients and may help to understand the mutational process in nonaffected individuals. (© 2021 American Society for Photobiology.)
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المشرفين على المادة:	0 (Mutagens)
SCR Disease Name:	Xeroderma Pigmentosum, Complementation Group C
تواريخ الأحداث:	Date Created: 20210913 Date Completed: 20220527 Latest Revision: 20220601
رمز التحديث:	20240628
DOI:	10.1111/php.13516
PMID:	34516658
قاعدة البيانات:	MEDLINE

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تدمد:	1751-1097
DOI:	10.1111/php.13516