دورية أكاديمية
Zinc pthalocyanine loaded poly (lactic acid) nanoparticles by double emulsion methodology for photodynamic therapy against 9 L/LacZ gliosarcoma cells.
| العنوان: | Zinc pthalocyanine loaded poly (lactic acid) nanoparticles by double emulsion methodology for photodynamic therapy against 9 L/LacZ gliosarcoma cells. |
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| المؤلفون: | de Oliveira BM; Organic Synthesis Laboratory, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil., Teodoro JBM; Organic Synthesis Laboratory, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil., Ambrósio JAR; Organic Synthesis Laboratory, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil., Gonçalves EP; Organic Synthesis Laboratory, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil., Beltrame M; Organic Synthesis Laboratory, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil., Cortez Marcolino LM; Laboratory of Photobiology Applied to Health, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil., Pinto JG; Laboratory of Photobiology Applied to Health, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil., Ferreira-Strixino J; Laboratory of Photobiology Applied to Health, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil., Simioni AR; Organic Synthesis Laboratory, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil. |
| المصدر: | Journal of biomaterials science. Polymer edition [J Biomater Sci Polym Ed] 2022 Jan; Vol. 33 (1), pp. 93-109. Date of Electronic Publication: 2021 Oct 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor and Francis Country of Publication: England NLM ID: 9007393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5624 (Electronic) Linking ISSN: 09205063 NLM ISO Abbreviation: J Biomater Sci Polym Ed Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : Abingdon, Oxon : Taylor and Francis Original Publication: Utrecht, The Netherlands : VSP, c1989- |
| مواضيع طبية MeSH: | Gliosarcoma* , Nanoparticles* , Organometallic Compounds* , Photochemotherapy*, Emulsions ; Humans ; Lac Operon ; Lactic Acid ; Photosensitizing Agents ; Polyesters ; Zinc ; Zinc Compounds |
| مستخلص: | Development delivery systems, such as nanoparticles, represent a growing area in biomedical research. Nanoparticles (NP) were prepared using a double-emulsion method to load zinc(II) phthalocyanine (ZnPc). NP were obtained using poly (lactic acid) (PLA). ZnPc is a second generation of photosensitizer used in photodynamic therapy (PDT). ZnPc loaded PLA nanoparticles (NPLA-ZnPc) were prepared by double-emulsion method, characterized and available in cellular culture. The mean nanoparticle size presented particle size was 384.7 ± 84.2 nm with polydispersity index (PDI) of 0.150 ± 0.015, and the encapsulation efficiency was of 83%. The nanoparticle formulations presented negative zeta potential values (-27.5 ± 1.0 mV), explaining their colloidal stability. ZnPc loaded nanoparticles maintain its photophysical behavior after encapsulation. Photosensitizer release from nanoparticles was sustained over 168 h with a biphasic ZnPc release profile. An in vitro phototoxic effect in range of 80% was observed in 9 L/LacZ gliosarcoma cells at laser light doses (10 J cm -2 ) with 3.0 µg mL -1 of NPLA-ZnPc. All the physical-chemical, photophysical and photobiological measurements performed allow us to conclude that ZnPc loaded PLGA nanoparticles is a promising drug delivery system for PDT. |
| فهرسة مساهمة: | Keywords: Photodynamic therapy; polymeric nanoparticles; zinc phthalocyanine |
| المشرفين على المادة: | 0 (Emulsions) 0 (Organometallic Compounds) 0 (Photosensitizing Agents) 0 (Polyesters) 0 (Zinc Compounds) 33X04XA5AT (Lactic Acid) J41CSQ7QDS (Zinc) |
| تواريخ الأحداث: | Date Created: 20210914 Date Completed: 20220126 Latest Revision: 20220126 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/09205063.2021.1980359 |
| PMID: | 34517784 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1568-5624 |
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| DOI: | 10.1080/09205063.2021.1980359 |