دورية أكاديمية
Risk Factors and Outcomes for Gastroparesis After Lung Transplantation.
العنوان: | Risk Factors and Outcomes for Gastroparesis After Lung Transplantation. |
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المؤلفون: | Blackett JW; Division of Digestive and Liver Diseases, Department of Medicine, New York Presbyterian Columbia University Medical Center, 622 West 168th Street, New York, NY, USA. jwb2158@cumc.columbia.edu., Benvenuto L; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, New York Presbyterian Columbia University Medical Center, New York, NY, USA., Leiva-Juarez MM; Division of Cardiac, Vascular, and Thoracic Surgery, Department of Surgery, New York Presbyterian Columbia University Medical Center, New York, NY, USA., D'Ovidio F; Division of Cardiac, Vascular, and Thoracic Surgery, Department of Surgery, New York Presbyterian Columbia University Medical Center, New York, NY, USA., Arcasoy S; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, New York Presbyterian Columbia University Medical Center, New York, NY, USA., Jodorkovsky D; Division of Digestive and Liver Diseases, Department of Medicine, New York Presbyterian Columbia University Medical Center, 622 West 168th Street, New York, NY, USA. |
المصدر: | Digestive diseases and sciences [Dig Dis Sci] 2022 Jun; Vol. 67 (6), pp. 2385-2394. Date of Electronic Publication: 2021 Sep 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Science + Business Media Original Publication: New York, Plenum Pub. Corp. |
مواضيع طبية MeSH: | Gastroesophageal Reflux*/diagnosis , Gastroesophageal Reflux*/epidemiology , Gastroesophageal Reflux*/etiology , Gastroparesis*/diagnosis , Gastroparesis*/epidemiology , Gastroparesis*/etiology , Lung Transplantation*/adverse effects, Humans ; Retrospective Studies ; Risk Factors |
مستخلص: | Background: Gastroparesis is common after lung transplantation and is associated with worse transplant outcomes, including the development of chronic lung allograft dysfunction (CLAD). This study sought to identify the prevalence, risk factors, and outcomes associated with a new diagnosis of gastroparesis after lung transplantation. Methods: This was a single-center retrospective study of patients who underwent lung transplantation in 2008-2018. The primary outcome was a new diagnosis of gastroparesis within 3 years of transplant. Secondary outcomes included a new diagnosis of gastroesophageal reflux and the association between gastroparesis and both post-transplant survival and CLAD-free survival. Multivariable logistic regression was used to compare diagnosis of gastroparesis and gastroesophageal reflux, while multivariable Cox proportional hazards models were used to analyze gastroparesis and post-transplant outcomes. Results: Of 616 patients with no prior history of gastroparesis, 107 (17.4%) were diagnosed with delayed gastric emptying within 3 years of transplant. On multivariable logistic regression, black race (OR 2.16, 95% CI 1.18-3.98, p = 0.013) was significantly associated with a new diagnosis of gastroparesis. Age, sex, history of diabetes, connective tissue disease, type of transplant, diagnosis group, renal function, and body mass index were not predictive of gastroparesis post-transplant. Gastroparesis was significantly associated with CLAD (HR 1.76, 95% CI 1.20-2.59, p = 0.004), but not with overall mortality (HR 1.16, p = 0.43). Conclusion: While gastroparesis is common after lung transplantation, it remains difficult to predict which patients will develop these complications post-transplant. Black patients were more likely to be diagnosed with gastroparesis after adjusting for relevant confounders. Gastroparesis is associated with increased risk of CLAD, and further studies are needed to assess whether early detection and treatment can reduce the incidence of CLAD. (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
التعليقات: | Comment in: Dig Dis Sci. 2022 Jun;67(6):1925-1926. (PMID: 34524596) |
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فهرسة مساهمة: | Keywords: Chronic lung allograft dysfunction; Delayed gastric emptying; Gastroesophageal reflux disease; Gastroparesis; Lung transplantation |
تواريخ الأحداث: | Date Created: 20210915 Date Completed: 20220608 Latest Revision: 20220808 |
رمز التحديث: | 20240628 |
DOI: | 10.1007/s10620-021-07249-y |
PMID: | 34524597 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-2568 |
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DOI: | 10.1007/s10620-021-07249-y |