دورية أكاديمية
Risk Factors and Outcomes for Gastroparesis After Lung Transplantation.
| العنوان: | Risk Factors and Outcomes for Gastroparesis After Lung Transplantation. |
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| المؤلفون: | Blackett JW; Division of Digestive and Liver Diseases, Department of Medicine, New York Presbyterian Columbia University Medical Center, 622 West 168th Street, New York, NY, USA. jwb2158@cumc.columbia.edu., Benvenuto L; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, New York Presbyterian Columbia University Medical Center, New York, NY, USA., Leiva-Juarez MM; Division of Cardiac, Vascular, and Thoracic Surgery, Department of Surgery, New York Presbyterian Columbia University Medical Center, New York, NY, USA., D'Ovidio F; Division of Cardiac, Vascular, and Thoracic Surgery, Department of Surgery, New York Presbyterian Columbia University Medical Center, New York, NY, USA., Arcasoy S; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, New York Presbyterian Columbia University Medical Center, New York, NY, USA., Jodorkovsky D; Division of Digestive and Liver Diseases, Department of Medicine, New York Presbyterian Columbia University Medical Center, 622 West 168th Street, New York, NY, USA. |
| المصدر: | Digestive diseases and sciences [Dig Dis Sci] 2022 Jun; Vol. 67 (6), pp. 2385-2394. Date of Electronic Publication: 2021 Sep 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Science + Business Media Original Publication: New York, Plenum Pub. Corp. |
| مواضيع طبية MeSH: | Gastroesophageal Reflux*/diagnosis , Gastroesophageal Reflux*/epidemiology , Gastroesophageal Reflux*/etiology , Gastroparesis*/diagnosis , Gastroparesis*/epidemiology , Gastroparesis*/etiology , Lung Transplantation*/adverse effects, Humans ; Retrospective Studies ; Risk Factors |
| مستخلص: | Background: Gastroparesis is common after lung transplantation and is associated with worse transplant outcomes, including the development of chronic lung allograft dysfunction (CLAD). This study sought to identify the prevalence, risk factors, and outcomes associated with a new diagnosis of gastroparesis after lung transplantation. Methods: This was a single-center retrospective study of patients who underwent lung transplantation in 2008-2018. The primary outcome was a new diagnosis of gastroparesis within 3 years of transplant. Secondary outcomes included a new diagnosis of gastroesophageal reflux and the association between gastroparesis and both post-transplant survival and CLAD-free survival. Multivariable logistic regression was used to compare diagnosis of gastroparesis and gastroesophageal reflux, while multivariable Cox proportional hazards models were used to analyze gastroparesis and post-transplant outcomes. Results: Of 616 patients with no prior history of gastroparesis, 107 (17.4%) were diagnosed with delayed gastric emptying within 3 years of transplant. On multivariable logistic regression, black race (OR 2.16, 95% CI 1.18-3.98, p = 0.013) was significantly associated with a new diagnosis of gastroparesis. Age, sex, history of diabetes, connective tissue disease, type of transplant, diagnosis group, renal function, and body mass index were not predictive of gastroparesis post-transplant. Gastroparesis was significantly associated with CLAD (HR 1.76, 95% CI 1.20-2.59, p = 0.004), but not with overall mortality (HR 1.16, p = 0.43). Conclusion: While gastroparesis is common after lung transplantation, it remains difficult to predict which patients will develop these complications post-transplant. Black patients were more likely to be diagnosed with gastroparesis after adjusting for relevant confounders. Gastroparesis is associated with increased risk of CLAD, and further studies are needed to assess whether early detection and treatment can reduce the incidence of CLAD. (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| التعليقات: | Comment in: Dig Dis Sci. 2022 Jun;67(6):1925-1926. (PMID: 34524596) |
| References: | Soykan I, Sivri B, Sarosiek I, Kiernan B, McCallum RW. Demography, clinical characteristics, psychological and abuse profiles, treatment, and long-term follow-up of patients with gastroparesis. Dig Dis Sci 1998;43:2398–2404. https://doi.org/10.1023/A:1026665728213 . (PMID: 10.1023/A:10266657282139824125) Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Melton LJ 3rd, Talley NJ. Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population. Am J Gastroenterol 2012;107:82–88. (PMID: 10.1038/ajg.2011.310) Bityutskiy LP, Soykan I, McCallum RW. Viral gastroparesis: a subgroup of idiopathic gastroparesis—clinical characteristics and long-term outcomes. Am J Gastroenterol 1997;92:1501–1504. (PMID: 9317072) Parkman HP, Hasler WL, Fisher RS, American Gastroenterological A. American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology 2004;127:1592–1622. (PMID: 10.1053/j.gastro.2004.09.055) Raviv Y, D’Ovidio F, Pierre A, Chaparro C, Freeman M, Keshavjee S, Singer LG. Prevalence of gastroparesis before and after lung transplantation and its association with lung allograft outcomes. Clin Transplant 2012;26:133–142. (PMID: 10.1111/j.1399-0012.2011.01434.x) Jung HK, Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Szarka LA, Mullan B, Talley NJ. The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006. Gastroenterology 2009;136:1225–1233. (PMID: 10.1053/j.gastro.2008.12.047) Berkowitz N, Schulman LL, McGregor C, Markowitz D. Gastroparesis after lung transplantation. Potential role in postoperative respiratory complications. Chest 1995;108:1602–1607. (PMID: 10.1378/chest.108.6.1602) Patti MG, Vela MF, Odell DD, Richter JE, Fisichella PM, Vaezi MF. The intersection of GERD, aspiration, and lung transplantation. J Laparoendosc Adv Surg Tech A 2016;26:501–505. (PMID: 10.1089/lap.2016.0170) Hadjiliadis D, Duane Davis R, Steele MP, Messier RH, Lau CL, Eubanks SS, Palmer SM. Gastroesophageal reflux disease in lung transplant recipients. Clin Transplant 2003;17:363–368. (PMID: 10.1034/j.1399-0012.2003.00060.x) Young LR, Hadjiliadis D, Davis RD, Palmer SM. Lung transplantation exacerbates gastroesophageal reflux disease. Chest 2003;124:1689–1693. (PMID: 10.1378/chest.124.5.1689) Jamie Dy F, Freiberger D, Liu E, Boyer D, Visner G, Rosen R. Impact of gastroesophageal reflux and delayed gastric emptying on pediatric lung transplant outcomes. J Heart Lung Transplant 2017;36:854–861. (PMID: 10.1016/j.healun.2017.01.005) D’Ovidio F, Mura M, Ridsdale R, Takahashi H, Waddell TK, Hutcheon M, Hadjiliadis D, Singer LG, Pierre A, Chaparro C, Gutierrez C, Miller L, Darling G, Liu M, Post M, Keshavjee S. The effect of reflux and bile acid aspiration on the lung allograft and its surfactant and innate immunity molecules SP-A and SP-D. Am J Transplant 2006;6:1930–1938. (PMID: 10.1111/j.1600-6143.2006.01357.x) Palmer SM, Miralles AP, Howell DN, Brazer SR, Tapson VF, Davis RD. Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest 2000;118:1214–1217. (PMID: 10.1378/chest.118.4.1214) Reid KR, McKenzie FN, Menkis AH, Novick RJ, Pflugfelder PW, Kostuk WJ, Ahmad D. Importance of chronic aspiration in recipients of heart-lung transplants. Lancet 1990;336:206–208. (PMID: 10.1016/0140-6736(90)91734-R) Glanville AR, Verleden GM, Todd JL, Benden C, Calabrese F, Gottlieb J, Hachem RR, Levine D, Meloni F, Palmer SM, Roman A, Sato M, Singer LG, Tokman S, Verleden SE, von der Thusen J, Vos R, Snell G. Chronic lung allograft dysfunction: definition and update of restrictive allograft syndrome-A consensus report from the Pulmonary Council of the ISHLT. J Heart Lung Transplant 2019;38:483–492. (PMID: 10.1016/j.healun.2019.03.008) Verleden GM, Glanville AR, Lease ED, Fisher AJ, Calabrese F, Corris PA, Ensor CR, Gottlieb J, Hachem RR, Lama V, Martinu T, Neil DAH, Singer LG, Snell G, Vos R. Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment—a consensus report from the Pulmonary Council of the ISHLT. J Heart Lung Transplant 2019;38:493–503. (PMID: 10.1016/j.healun.2019.03.009) Hartwig MG, Davis RD. Gastroesophageal reflux disease-induced aspiration injury following lung transplantation. Curr Opin Organ Transplant 2012;17:474–478. (PMID: 10.1097/MOT.0b013e328357f84f) Hartwig MG, Anderson DJ, Onaitis MW, Reddy S, Snyder LD, Lin SS, Davis RD. Fundoplication after lung transplantation prevents the allograft dysfunction associated with reflux. Ann Thorac Surg 2011;92:462–468 (discussion; 468–469). (PMID: 10.1016/j.athoracsur.2011.04.035) Valapour M, Lehr CJ, Skeans MA, Smith JM, Uccellini K, Goff R, Foutz J, Israni AK, Snyder JJ, Kasiske BL. OPTN/SRTR 2018 annual data report: lung. Am J Transplant 2020;20:427–508. (PMID: 10.1111/ajt.15677) Kulkarni HS, Cherikh WS, Chambers DC, Garcia VC, Hachem RR, Kreisel D, Puri V, Kozower BD, Byers DE, Witt CA, Alexander-Brett J, Aguilar PR, Tague LK, Furuya Y, Patterson GA, Trulock EP 3rd, Yusen RD. Bronchiolitis obliterans syndrome-free survival after lung transplantation: an International Society for Heart and Lung Transplantation Thoracic Transplant Registry analysis. J Heart Lung Transplant 2019;38:5–16. (PMID: 10.1016/j.healun.2018.09.016) Farrell MB. Gastric emptying scintigraphy. J Nucl Med Technol 2019;47:111–119. (PMID: 10.2967/jnmt.117.227892) Sodhi SS, Guo JP, Maurer AH, O’Brien G, Srinivasan R, Parkman HP. Gastroparesis after combined heart and lung transplantation. J Clin Gastroenterol 2002;34:34–39. (PMID: 10.1097/00004836-200201000-00007) Bodet-Milin C, Querellou S, Oudoux A, Haloun A, Horeau-Llanglard D, Carlier T, Bizais Y, Couturier O. Delayed gastric emptying scintigraphy in cystic fibrosis patients before and after lung transplantation. J Heart Lung Transplant 2006;25:1077–1083. (PMID: 10.1016/j.healun.2006.04.013) Cantu E 3rd, Appel JZ 3rd, Hartwig MG, Woreta H, Green C, Messier R, Palmer SM, Davis RD Jr. J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease. Ann Thorac Surg 2004;78:1142–1151. (PMID: 10.1016/j.athoracsur.2004.04.044) Meyer KC, Raghu G, Verleden GM, Corris PA, Aurora P, Wilson KC, Brozek J, Glanville AR. Committee IAEBTF, Committee IAEBTF: an international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. Eur Respir J 2014;44:1479–1503. (PMID: 10.1183/09031936.00107514) D’Ovidio F, Singer LG, Hadjiliadis D, Pierre A, Waddell TK, de Perrot M, Hutcheon M, Miller L, Darling G, Keshavjee S. Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Ann Thorac Surg 2005;80:1254–1260. (PMID: 10.1016/j.athoracsur.2005.03.106) Camilleri M, Chedid V, Ford AC, Haruma K, Horowitz M, Jones KL, Low PA, Park SY, Parkman HP, Stanghellini V. Gastroparesis. Nat Rev Dis Primers 2018;4:41. (PMID: 10.1038/s41572-018-0038-z) Smit JGA, van der Bij W, Erasmus ME, Verschuuren EAM. Gastroparesis after lung transplantation: prevalence, reversibility and relation with outcome. J Heart Lung Transplant 2013;32:S264. (PMID: 10.1016/j.healun.2013.01.688) Friedenberg FK, Kowalczyk M, Parkman HP. The influence of race on symptom severity and quality of life in gastroparesis. J Clin Gastroenterol 2013;47:757–761. (PMID: 10.1097/MCG.0b013e3182819aae) Parkman HP, Yamada G, Van Natta ML, Yates K, Hasler WL, Sarosiek I, Grover M, Schey R, Abell TL, Koch KL, Kuo B, Clarke J, Farrugia G, Nguyen L, Snape WJ, Miriel L, Tonascia J, Hamilton F, Pasricha PJ, McCallum RW. Ethnic, racial, and sex differences in etiology, symptoms, treatment, and symptom outcomes of patients with gastroparesis. Clin Gastroenterol Hepatol 2019;17:1489-1499e1488. (PMID: 10.1016/j.cgh.2018.10.050) Ye Y, Jiang B, Manne S, Moses PL, Almansa C, Bennett D, Dolin P, Ford AC. Epidemiology and outcomes of gastroparesis, as documented in general practice records, in the United Kingdom. Gut 2020;70:644–653. (PMID: 10.1136/gutjnl-2020-321277) Adegunsoye A, Strek ME, Garrity E, Guzy R, Bag R. Comprehensive care of the lung transplant patient. Chest 2017;152:150–164. (PMID: 10.1016/j.chest.2016.10.001) Carbone F, De Buysscher R, Van den Houte K, Schol J, Goelen N, Tack J. Relationship between gastric emptying rate and simultaneously assessed symptoms in functional dyspepsia. Clin Gastroenterol Hepatol. 2021. https://doi.org/10.1016/j.cgh.2021.03.023 . (PMID: 10.1016/j.cgh.2021.03.02333746098) Vijayvargiya P, Jameie-Oskooei S, Camilleri M, Chedid V, Erwin PJ, Murad MH. Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis. Gut 2019;68:804–813. (PMID: 10.1136/gutjnl-2018-316405) Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L, American College of G. Clinical guideline: management of gastroparesis. Am J Gastroenterol 2013;108:18–37. (PMID: 10.1038/ajg.2012.373) |
| فهرسة مساهمة: | Keywords: Chronic lung allograft dysfunction; Delayed gastric emptying; Gastroesophageal reflux disease; Gastroparesis; Lung transplantation |
| تواريخ الأحداث: | Date Created: 20210915 Date Completed: 20220608 Latest Revision: 20220808 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10620-021-07249-y |
| PMID: | 34524597 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2568 |
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| DOI: | 10.1007/s10620-021-07249-y |