دورية أكاديمية
أعرض في EDS

Oscillatory Pattern of Sympathetic Nerve Bursts Is Associated With Baroreflex Function in Heart Failure Patients With Reduced Ejection Fraction.

التفاصيل البيبلوغرافية
العنوان: Oscillatory Pattern of Sympathetic Nerve Bursts Is Associated With Baroreflex Function in Heart Failure Patients With Reduced Ejection Fraction.
المؤلفون: Toschi-Dias E; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.; Department of Internal Medicine, Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlínico, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Montano N; Department of Internal Medicine, Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlínico, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Tobaldini E; Department of Internal Medicine, Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlínico, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Trevizan PF; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Groehs RV; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Antunes-Correa LM; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Nobre TS; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Lobo DM; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Sales ARK; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Ueno-Pardi LM; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., de Matos LDNJ; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Oliveira PA; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Braga AMFW; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Alves MJNN; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Negrão CE; Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.; School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil., Rondon MUPB; School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
المصدر: Frontiers in neuroscience [Front Neurosci] 2021 Aug 31; Vol. 15, pp. 669535. Date of Electronic Publication: 2021 Aug 31 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Sympathetic hyperactivation and baroreflex dysfunction are hallmarks of heart failure with reduced ejection fraction (HFrEF). However, it is unknown whether the progressive loss of phasic activity of sympathetic nerve bursts is associated with baroreflex dysfunction in HFrEF patients. Therefore, we investigated the association between the oscillatory pattern of muscle sympathetic nerve activity (LF MSNA /HF MSNA ) and the gain and coupling of the sympathetic baroreflex function in HFrEF patients. In a sample of 139 HFrEF patients, two groups were selected according to the level of LF MSNA /HF MSNA index: (1) Lower LF MSNA /HF MSNA (lower terciles, n = 46, aged 53 ± 1 y) and (2) Higher LF MSNA /HF MSNA (upper terciles, n = 47, aged 52 ± 2 y). Heart rate (ECG), arterial pressure (oscillometric method), and muscle sympathetic nerve activity (microneurography) were recorded for 10 min in patients while resting. Spectral analysis of muscle sympathetic nerve activity was conducted to assess the LF MSNA /HF MSNA , and cross-spectral analysis between diastolic arterial pressure, and muscle sympathetic nerve activity was conducted to assess the sympathetic baroreflex function. HFrEF patients with lower LF MSNA /HF MSNA had reduced left ventricular ejection fraction (26 ± 1 vs. 29 ± 1%, P = 0.03), gain (0.15 ± 0.03 vs. 0.30 ± 0.04 a.u./mmHg, P < 0.001) and coupling of sympathetic baroreflex function (0.26 ± 0.03 vs. 0.56 ± 0.04%, P < 0.001) and increased muscle sympathetic nerve activity (48 ± 2 vs. 41 ± 2 bursts/min, P < 0.01) and heart rate (71 ± 2 vs. 61 ± 2 bpm, P < 0.001) compared with HFrEF patients with higher LF MSNA /HF MSNA . Further analysis showed an association between the LF MSNA /HF MSNA with coupling of sympathetic baroreflex function ( R = 0.56, P < 0.001) and left ventricular ejection fraction ( R = 0.23, P = 0.02). In conclusion, there is a direct association between LF MSNA /HF MSNA and sympathetic baroreflex function and muscle sympathetic nerve activity in HFrEF patients. This finding has clinical implications, because left ventricular ejection fraction is less in the HFrEF patients with lower LF MSNA /HF MSNA .
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Toschi-Dias, Montano, Tobaldini, Trevizan, Groehs, Antunes-Correa, Nobre, Lobo, Sales, Ueno-Pardi, de Matos, Oliveira, Braga, Alves, Negrão and Rondon.)
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فهرسة مساهمة: Keywords: baroreflex control; cardiovascular variabilities; heart failure; oscillatory pattern; sympathetic nervous system
تواريخ الأحداث: Date Created: 20210917 Latest Revision: 20210918
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8439256
DOI: 10.3389/fnins.2021.669535
PMID: 34531714
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-4548
DOI:10.3389/fnins.2021.669535