دورية أكاديمية
Effects of Controlled Generator Fume Emissions on the Levels of Troponin I, C-Reactive Protein and Oxidative Stress Markers in Dogs: Exploring Air Pollution-Induced Cardiovascular Disease in a Low-Resource Country.
| العنوان: | Effects of Controlled Generator Fume Emissions on the Levels of Troponin I, C-Reactive Protein and Oxidative Stress Markers in Dogs: Exploring Air Pollution-Induced Cardiovascular Disease in a Low-Resource Country. |
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| المؤلفون: | Eze UU; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu, Nigeria., Eke IG; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu, Nigeria., Anakwue RC; Departments of Medicine, Pharmacology/Therapeutics, Faculty of Medical Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria. raphael.anakwue@unn.edu.ng.; Environment and Health Research Group, University of Nigeria, Nsukka, Enugu, Nigeria. raphael.anakwue@unn.edu.ng., Oguejiofor CF; Department of Veterinary Obstetrics and Reproductive Diseases, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu, Nigeria., Onyejekwe OB; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu, Nigeria., Udeani IJ; Veterinary Teaching Hospital, University of Nigeria, Nsukka, Enugu, Nigeria., Onunze CJ; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu, Nigeria., Obed UJ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu, Nigeria., Eze AA; Department of Veterinary Obstetrics and Reproductive Diseases, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu, Nigeria., Anaga AO; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu, Nigeria., Anene BM; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu, Nigeria. |
| المصدر: | Cardiovascular toxicology [Cardiovasc Toxicol] 2021 Dec; Vol. 21 (12), pp. 1019-1032. Date of Electronic Publication: 2021 Sep 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 101135818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0259 (Electronic) Linking ISSN: 15307905 NLM ISO Abbreviation: Cardiovasc Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Totowa, NJ : Humana Press, c2001- |
| مواضيع طبية MeSH: | Developing Countries*, Air Pollutants/*toxicity , C-Reactive Protein/*metabolism , Cardiovascular Diseases/*chemically induced , Electric Power Supplies/*adverse effects , Gasoline/*toxicity , Oxidative Stress/*drug effects , Troponin I/*blood, Animals ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/physiopathology ; Dogs ; Heart Rate/drug effects ; Inhalation Exposure ; Male ; Nigeria ; Respiratory Rate/drug effects ; Risk Assessment ; Time Factors |
| مستخلص: | Exhaust fumes from petrol/diesel-powered electric generators contribute significantly to air pollution in many developing countries, constituting health hazards to both humans and animals. This study evaluated the serum concentrations of Troponin I (TnI), C-reactive protein (CRP) and serum levels/activities of oxidative stress markers: catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO) and superoxide dismutase (SOD) in dogs experimentally exposed to graded levels of petrol generator exhaust fume (PGEF). Sixteen (16) healthy and adult male Basenji dogs were randomly assigned into four groups (A-D). Group A was the unexposed control while groups B, C and D were exposed to PGEF for 1, 2 and 3 h per day, respectively, for 90 days. Repeated analysis were performed at the baseline, and every thirty days, for a total of 90 days. There was a significant interaction (p < 0.05) between the effects of PGEF exposure level (in h/day) and duration of exposure (in months) on all the tested serum parameters. There was a significant main effect (p < 0.05) for PGEF exposure level on the serum parameters. As the level of PGEF exposure was increased, the serum concentrations of TnI, CRP, CAT, MDA and NO increased, GSH decreased, whereas SOD activity increased by day 30 but declined at the end. Moreover, there was a significant simple main effect (p < 0.05) for duration of PGEF exposure. All the parameters increased as the duration of PGEF exposure was increased to 90 days except GSH concentration which decreased, whereas SOD activity increased initially but declined at the end of the study. Thus, there was increased serum concentrations of TnI, CRP and increased oxidative stress in the PGEF-exposed dogs. These findings are instructive and could be grounds for further studies on air pollutants-induced cardiovascular disease given the widespread use of electricity generators in many low-resource countries. (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Air pollution; Cardiovascular disease; Dogs; Generator exhaust fume; Low-resource countries; Toxicity |
| المشرفين على المادة: | 0 (Air Pollutants) 0 (Biomarkers) 0 (Gasoline) 0 (Troponin I) 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20210917 Date Completed: 20220224 Latest Revision: 20220224 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s12012-021-09693-8 |
| PMID: | 34533688 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1007/s12012-021-09693-8 |