دورية أكاديمية
Construction of a Pyrimidine Framework through [3 + 2 + 1] Annulation of Amidines, Ketones, and N , N -Dimethylaminoethanol as One Carbon Donor.
| العنوان: | Construction of a Pyrimidine Framework through [3 + 2 + 1] Annulation of Amidines, Ketones, and N , N -Dimethylaminoethanol as One Carbon Donor. |
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| المؤلفون: | Qin Z; Institute of Advanced Studies and School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, P R China.; School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P R China., Ma Y; Institute of Advanced Studies and School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, P R China.; School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P R China., Li F; School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P R China. |
| المصدر: | The Journal of organic chemistry [J Org Chem] 2021 Oct 01; Vol. 86 (19), pp. 13734-13743. Date of Electronic Publication: 2021 Sep 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Columbus Oh : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مواضيع طبية MeSH: | Amidines* , Ketones*, Carbon ; Catalysis ; Deanol ; Pyrimidines |
| مستخلص: | An efficient, facile, and eco-friendly synthesis of pyrimidine derivatives has been developed. It involves a [3 + 2 + 1] three-component annulation of amidines, ketones, and one carbon source. N , N -Dimethylaminoethanol is oxidized through C(sp 3 )-H activation to provide the carbon donor. One C-C and two C-N bonds are formed during the oxidative annulation process. The reaction shows good tolerance to many important functional groups in air, making this methodology a highly versatile alternative, and significant improvement to the existing methods for structuring a pyrimidine framework, especially 4-aliphatic pyrimidines. |
| المشرفين على المادة: | 0 (Amidines) 0 (Ketones) 0 (Pyrimidines) 2N6K9DRA24 (Deanol) 7440-44-0 (Carbon) K8CXK5Q32L (pyrimidine) |
| تواريخ الأحداث: | Date Created: 20210920 Date Completed: 20211022 Latest Revision: 20211022 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1021/acs.joc.1c01847 |
| PMID: | 34541847 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6904 |
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| DOI: | 10.1021/acs.joc.1c01847 |