دورية أكاديمية
أعرض في EDS

Analysis of the Specificity of Auto-Reactive Antibodies to Individual Fragments of the Extracellular Domain of Desmoglein 3 in Patients with Pemphigus Vulgaris.

التفاصيل البيبلوغرافية
العنوان: Analysis of the Specificity of Auto-Reactive Antibodies to Individual Fragments of the Extracellular Domain of Desmoglein 3 in Patients with Pemphigus Vulgaris.
المؤلفون: Kubanov AA; State Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia. nikonorov_all@mail.ru., Deryabin DG; State Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Shpilevaya MV; State Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Karamova AE; State Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Nikonorov AA; State Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Larina EN; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Aliev TK; M. V. Lomonosov Moscow State University, Moscow, Russia., Dolgikh DA; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; M. V. Lomonosov Moscow State University, Moscow, Russia., Bobik TV; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Smirnov IV; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Gabibov AG; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Kirpichnikov MP; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; M. V. Lomonosov Moscow State University, Moscow, Russia.
المصدر: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 Aug; Vol. 171 (4), pp. 475-479. Date of Electronic Publication: 2021 Sep 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
مواضيع طبية MeSH: Autoantibodies/*immunology , Desmoglein 3/*immunology , Pemphigus/*immunology, Animals ; Antibody Specificity ; Autoantibodies/blood ; Autoantibodies/metabolism ; CHO Cells ; Cricetulus ; Desmoglein 3/chemistry ; Desmoglein 3/metabolism ; Enzyme-Linked Immunosorbent Assay ; Epitope Mapping ; Extracellular Space ; Humans ; Pemphigus/blood ; Pemphigus/pathology ; Peptide Fragments/immunology ; Protein Domains/immunology
مستخلص: A method for the analysis of the epitope specificity of auto-reactive antibodies to desmoglein 3 (Dsg3) using competitive ELISA has been developed. It is based on a two-stage solid-phase ELISA with initial "depletion" of auto-reactive antibodies against the studied epitope and subsequent quantitative assessment of antibodies against full-length extracellular domain Dsg3. The proposed approach for assessing the specificity of the autoimmune response in patients with pemphigus vulgaris can provide in the future the possibility to personalize the therapy using plasmapheresis by preliminary selection of the antigenic composition of the extracorporeal immunosorbent.
(© 2021. Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: ELISA; autoantibodies; autoimmunity; desmoglein 3; pemphigus vulgaris; specificity
المشرفين على المادة: 0 (Autoantibodies)
0 (Desmoglein 3)
0 (Peptide Fragments)
تواريخ الأحداث: Date Created: 20210920 Date Completed: 20220131 Latest Revision: 20220131
رمز التحديث: 20240628
DOI: 10.1007/s10517-021-05254-9
PMID: 34542752
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-8221
DOI:10.1007/s10517-021-05254-9