دورية أكاديمية
أعرض في EDS

Regulation of integrin and extracellular matrix genes by HNRNPL is necessary for epidermal renewal.

التفاصيل البيبلوغرافية
العنوان: Regulation of integrin and extracellular matrix genes by HNRNPL is necessary for epidermal renewal.
المؤلفون: Li J; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China., Chen Y; Department of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California San Diego, La Jolla, California, United States of America., Tiwari M; Department of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California San Diego, La Jolla, California, United States of America., Bansal V; Department of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California San Diego, La Jolla, California, United States of America., Sen GL; Department of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California San Diego, La Jolla, California, United States of America.
المصدر: PLoS biology [PLoS Biol] 2021 Sep 20; Vol. 19 (9), pp. e3001378. Date of Electronic Publication: 2021 Sep 20 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, [2003]-
مواضيع طبية MeSH: Epidermal Cells/*metabolism , Extracellular Matrix/*metabolism , Heterogeneous-Nuclear Ribonucleoprotein L/*metabolism , Integrins/*metabolism, Cell Differentiation ; Cells, Cultured ; Chromatin ; Epidermis/growth & development ; Extracellular Matrix/genetics ; Humans ; Integrins/genetics ; Stem Cells
مستخلص: Stratified epithelia such as the epidermis require coordinated regulation of stem and progenitor cell proliferation, survival, and differentiation to maintain homeostasis. Integrin-mediated anchorage of the basal layer stem cells of the epidermis to the underlying dermis through extracellular matrix (ECM) proteins is crucial for this process. It is currently unknown how the expression of these integrins and ECM genes are regulated. Here, we show that the RNA-binding protein (RBP) heterogeneous nuclear ribonucleoprotein L (HNRNPL) binds to these genes on chromatin to promote their expression. HNRNPL recruits RNA polymerase II (Pol II) to integrin/ECM genes and is required for stabilizing Pol II transcription through those genes. In the absence of HNRNPL, the basal layer of the epidermis where the stem cells reside prematurely differentiates and detaches from the underlying dermis due to diminished integrin/ECM expression. Our results demonstrate a critical role for RBPs on chromatin to maintain stem and progenitor cell fate by dictating the expression of specific classes of genes.
Competing Interests: The authors have declared that no competing interests exist.
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معلومات مُعتمدة: R01 AR066530 United States AR NIAMS NIH HHS; R01 AR072590 United States AR NIAMS NIH HHS; R01 AR081215 United States AR NIAMS NIH HHS; R01 CA225463 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Chromatin)
0 (Heterogeneous-Nuclear Ribonucleoprotein L)
0 (Integrins)
تواريخ الأحداث: Date Created: 20210920 Date Completed: 20211119 Latest Revision: 20240515
رمز التحديث: 20240515
مُعرف محوري في PubMed: PMC8452081
DOI: 10.1371/journal.pbio.3001378
PMID: 34543262
قاعدة البيانات: MEDLINE
الوصف
تدمد:1545-7885
DOI:10.1371/journal.pbio.3001378