دورية أكاديمية
Uniform versus non-uniform dose prescription for proton stereotactic body radiotherapy of liver tumors investigated by extensive motion-including treatment simulations.
| العنوان: | Uniform versus non-uniform dose prescription for proton stereotactic body radiotherapy of liver tumors investigated by extensive motion-including treatment simulations. |
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| المؤلفون: | Worm ES; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Hansen R; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Høyer M; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark., Weber B; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark., Mortensen H; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark., Poulsen PR; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. |
| المصدر: | Physics in medicine and biology [Phys Med Biol] 2021 Oct 12; Vol. 66 (20). Date of Electronic Publication: 2021 Oct 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol : IOP Publishing |
| مواضيع طبية MeSH: | Liver Neoplasms*/radiotherapy , Lung Neoplasms*/radiotherapy , Radiosurgery*/adverse effects , Radiotherapy, Intensity-Modulated*, Humans ; Prescriptions ; Protons ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted |
| مستخلص: | Compared to x-ray-based stereotactic body radiotherapy (SBRT) of liver cancer, proton SBRT may reduce the normal liver tissue dose. For an optimal trade-off between target and liver dose, a non-uniform dose prescription is often applied in x-ray SBRT, but lacks investigation for proton SBRT. Also, proton SBRT is prone to breathing-induced motion-uncertainties causing target mishit or dose alterations by interplay with the proton delivery. This study investigated non-uniform and uniform dose prescription in proton-based liver SBRT, including effects of rigid target motion observed during planning-4DCT and treatment. The study was based on 42 x-ray SBRT fractions delivered to 14 patients under electromagnetic motion-monitoring. For each patient, a non-uniform and uniform proton plan were made. The uniform plan was renormalized to be iso-toxic with the non-uniform plan using a NTCP model for radiation-induced liver disease. The motion data were used in treatment simulations to estimate the delivered target dose with rigid motion. Treatment simulations were performed with and without a repainting scheme designed to mitigate interplay effects. Including rigid motion, the achieved CTV mean dose after three fractions delivered without repainting was on average (±SD) 24.8 ± 8.4% higher and the D (© 2021 Institute of Physics and Engineering in Medicine.) |
| فهرسة مساهمة: | Keywords: intrafraction motion; liver SBRT; particle therapy; treatment planning |
| المشرفين على المادة: | 0 (Protons) |
| تواريخ الأحداث: | Date Created: 20210920 Date Completed: 20220415 Latest Revision: 20220415 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1088/1361-6560/ac2880 |
| PMID: | 34544071 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1361-6560 |
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| DOI: | 10.1088/1361-6560/ac2880 |