دورية أكاديمية
Microstructural Characterization of Resistance Artery Remodelling in Diabetes Mellitus.
| العنوان: | Microstructural Characterization of Resistance Artery Remodelling in Diabetes Mellitus. |
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| المؤلفون: | Bell JS; Department of Physics, University of Exeter, Exeter, United Kingdom.; Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.; School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom., Adio AO; Diabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom., Pitt A; Diabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom., Hayman L; Diabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom., Thorn CE; Diabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom., Shore AC; Diabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom., Whatmore JL; Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom., Winlove CP; Department of Physics, University of Exeter, Exeter, United Kingdom. |
| المصدر: | Journal of vascular research [J Vasc Res] 2022; Vol. 59 (1), pp. 50-60. Date of Electronic Publication: 2021 Sep 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: S. Karger Country of Publication: Switzerland NLM ID: 9206092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0135 (Electronic) Linking ISSN: 10181172 NLM ISO Abbreviation: J Vasc Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : S. Karger, c1992- |
| مواضيع طبية MeSH: | Vascular Remodeling*, Abdominal Fat/*blood supply , Arteries/*pathology , Diabetes Mellitus, Type 2/*pathology, Aged ; Arterial Pressure ; Arteries/physiopathology ; Case-Control Studies ; Diabetes Mellitus, Type 2/physiopathology ; Elastic Tissue/pathology ; Female ; Fibrillar Collagens ; Humans ; Male ; Mechanotransduction, Cellular ; Microscopy, Fluorescence, Multiphoton ; Middle Aged ; Stress, Mechanical ; Vascular Resistance |
| مستخلص: | Introduction: Microvascular remodelling is a symptom of cardiovascular disease. Despite the mechanical environment being recognized as a major contributor to the remodelling process, it is currently only understood in a rudimentary way. Objective: A morphological and mechanical evaluation of the resistance vasculature in health and diabetes mellitus. Methods: The cells and extracellular matrix of human subcutaneous resistance arteries from abdominal fat biopsies were imaged using two-photon fluorescence and second harmonic generation at varying transmural pressure. The results informed a two-layer mechanical model. Results: Diabetic resistance arteries reduced in wall area as pressure was increased. This was attributed to the presence of thick, straight collagen fibre bundles that braced the outer wall. The abnormal mechanical environment caused the internal elastic lamina and endothelial and vascular smooth muscle cell arrangements to twist. Conclusions: Our results suggest diabetic microvascular remodelling is likely to be stress-driven, comprising at least 2 stages: (1) Laying down of adventitial bracing fibres that limit outward distension, and (2) Deposition of additional collagen in the media, likely due to the significantly altered mechanical environment. This work represents a step towards elucidating the local stress environment of cells, which is crucial to build accurate models of mechanotransduction in disease. (© 2021 The Author(s) Published by S. Karger AG, Basel.) |
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| معلومات مُعتمدة: | PG/11/17/28788 United Kingdom BHF_ British Heart Foundation; MR/S037829/1 United Kingdom MRC_ Medical Research Council; United Kingdom DH_ Department of Health |
| فهرسة مساهمة: | Keywords: Collagen; Diabetes mellitus; Elastin; Multiphoton microscopy; Remodelling |
| المشرفين على المادة: | 0 (Fibrillar Collagens) |
| تواريخ الأحداث: | Date Created: 20210920 Date Completed: 20220222 Latest Revision: 20220222 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8820441 |
| DOI: | 10.1159/000517856 |
| PMID: | 34544081 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1423-0135 |
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| DOI: | 10.1159/000517856 |