دورية أكاديمية
Linalool as a Therapeutic and Medicinal Tool in Depression Treatment: A Review.
| العنوان: | Linalool as a Therapeutic and Medicinal Tool in Depression Treatment: A Review. |
|---|---|
| المؤلفون: | Dos Santos ÉRQ; Laboratório de Farmacologia da Inflamação e Comportamento, Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil., Maia JGS; Programa de Pós-Graduação em Química, Centro de Ciências Exatas e Tecnologia, Universidade Federal do Maranhão, 65080-805São Luís, MA, Brazil., Fontes-Júnior EA; Laboratório de Farmacologia da Inflamação e Comportamento, Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil., do Socorro Ferraz Maia C; Laboratório de Farmacologia da Inflamação e Comportamento, Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. |
| المصدر: | Current neuropharmacology [Curr Neuropharmacol] 2022; Vol. 20 (6), pp. 1073-1092. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101157239 Publication Model: Print Cited Medium: Internet ISSN: 1875-6190 (Electronic) Linking ISSN: 1570159X NLM ISO Abbreviation: Curr Neuropharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2003- |
| مواضيع طبية MeSH: | Depression*/drug therapy , Oils, Volatile*/pharmacology, Acyclic Monoterpenes/therapeutic use ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Humans |
| مستخلص: | Depression is a prevalent disease worldwide, limiting psychosocial functioning and thequality of life. Linalool is the main constituent of some essential oils from aromatic plants, representing about 70% of these volatile concentrates. Evidence of the linalool activity on the central nervous system, mainly acting as an antidepressant agent, is increasingly abundant. This review aimed to extend the knowledge of linalool's antidepressant action mechanisms, which is fundamental for future research, intending to highlight this natural compound as a new antidepressant phytomedication. A critical analysis is proposed here with probable hypotheses of the synergic mechanisms that support the evidence of antidepressant effects of the linalool. The literature search has been conducted in databases for published scientific articles before December 2020, using relevant keywords. Several pieces of evidence point to the anticonvulsant, sedative, and anxiolytic actions. In addition to these activities, other studies have revealed that linalool acts on the monoaminergic and neuroendocrine systems, inflammatory process, oxidative stress, and neurotrophic factors, such as BDNF, resulting in considerable advances in the knowledge of the etiology of depression. In this context, linalool emerges as a promising bioactive compound in the therapeutic arsenal, capable of interacting with numerous pathophysiological factors and acting on several targets. This review claims to contribute to future studies, highlighting the gaps in the linalool knowledge, such as its kinetics, doses, routes of administration, and multiple targets of interaction, to clarify its antidepressant activity. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
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| معلومات مُعتمدة: | 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); 311335/2019-5 Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq |
| فهرسة مساهمة: | Keywords: Linalool; antidepressant bioactive compound; depression; essential oils; neuropharmacological effects; therapeutic effects |
| المشرفين على المادة: | 0 (Acyclic Monoterpenes) 0 (Antidepressive Agents) 0 (Oils, Volatile) D81QY6I88E (linalool) |
| تواريخ الأحداث: | Date Created: 20210921 Date Completed: 20220525 Latest Revision: 20230210 |
| رمز التحديث: | 20230210 |
| مُعرف محوري في PubMed: | PMC9886818 |
| DOI: | 10.2174/1570159X19666210920094504 |
| PMID: | 34544345 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-6190 |
|---|---|
| DOI: | 10.2174/1570159X19666210920094504 |