دورية أكاديمية
[Reinterpretation of the Malpighian body in light of the existence of a single glomerular arteriole (Trabucco and Marquez)].
| العنوان: | [Reinterpretation of the Malpighian body in light of the existence of a single glomerular arteriole (Trabucco and Marquez)]. |
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| عنوان ترانسليتريتد: | Reinterpretación de la estructura del corpúsculo de Malpighi en función de la existencia de una sola arteriola glomerular (Trabucco y Márquez). |
| المؤلفون: | Sánchez Fernández de la Vega J; Anatomía Patológica, Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Madrid, España. Electronic address: jaisanferv@gmail.com., Martínez-Onsurbe MP; Anatomía Patológica, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España., Alonso Garcia S; Anatomía Patológica, Hospital Universitario Infanta Leonor, Madrid, España., Alba Losada J; Anatomía Patológica, Hospital Polusa, Lugo, España., Alonso Riaño M; Anatomía Patológica, Hospital Universitario 12 de Octubre, Madrid, España., Pardo Mindán FJ; Anatomía Patológica, Universidad de Navarra, Pamplona, España. |
| المصدر: | Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia [Rev Esp Patol] 2021 Oct-Dec; Vol. 54 (4), pp. 220-233. Date of Electronic Publication: 2021 Mar 01. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | Spanish; Castilian |
| بيانات الدورية: | Publisher: Elsevier España Country of Publication: Spain NLM ID: 100885154 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1988-561X (Electronic) Linking ISSN: 16998855 NLM ISO Abbreviation: Rev Esp Patol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2006->: Barcelona : Elsevier España Original Publication: Barcelona ; Philadelphia : Prous Science, |
| مواضيع طبية MeSH: | Endothelial Cells* , Kidney Glomerulus*, Actins ; Arterioles ; Child ; Humans ; Kidney |
| مستخلص: | Introduction: In 1842 William Bowman described the microvascular system of the Malpighian body. Electron microscopic studies definitively revealed the spatial structure of its mesangial-capillary-epithelial component. In 1952-54 Trabucco and Marquez challenged the ideas of Bowman, demonstrating the existence of a single glomerular arteriole. Our study supports the finding of a single glomerular arteriole, leading to a definitive interpretation of the Malpighian body structure. Materials and Methods: Serial histological studies were carried out of the vascular pole in a case of oligomeganephrotic renal hypoplasia and the immunohistochemical study of embryonal glomerular development (15 embryos aged between 7 and 11weeks), with alpha-actin (smooth muscle marker), CD31 and CD34 (endothelial markers) and CD10 (podocyte marker). Results: The study of the glomerular vascular pole in the case of oligomeganephrotic renal hypoplasia supports the existence of a single glomerular arteriole. Our immunohistochemical study confirmed this finding and provided data on the morphogenesis of the mesangial-capillary-epithelial component of the Malpighian body. Conclusions: There exist a single glomerular arteriole. Mesangial and endothelial cells originating from a single glomerular arteriole interact with an epithelial component derived from the nephrogenic vesicle which then generate the lobular glomerular tuft, providing the basis for a definitive interpretation of the structure of the Malpighian body. There is no scientific base to the interpretation of the glomerular microvascular system as having two glomerular arterioles with an intercalated capillary network. (Copyright © 2021 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Arteriola glomerular única; Corpúsculo de Malpighi; Malpighian body; Microvascular system; Single glomerular arteriole; Sistema microvascular del corpúsculo de Malpighi |
| المشرفين على المادة: | 0 (Actins) |
| تواريخ الأحداث: | Date Created: 20210921 Date Completed: 20220113 Latest Revision: 20220113 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.patol.2021.01.005 |
| PMID: | 34544552 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1988-561X |
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| DOI: | 10.1016/j.patol.2021.01.005 |