دورية أكاديمية
MRI Features Associated with Histology of Benign Prostatic Hyperplasia Nodules: Generation of a Predictive Model.
| العنوان: | MRI Features Associated with Histology of Benign Prostatic Hyperplasia Nodules: Generation of a Predictive Model. |
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| المؤلفون: | Dai JC; Department of Urology, and UT Southwestern Medical Center, Dallas, Texas, USA., Morgan TN; Department of Urology, and UT Southwestern Medical Center, Dallas, Texas, USA., Goueli R; Department of Urology, and UT Southwestern Medical Center, Dallas, Texas, USA., Parrott D; Department of Radiology, UT Southwestern Medical Center, Dallas, Texas, USA., Kenigsberg A; Department of Urology, and UT Southwestern Medical Center, Dallas, Texas, USA., Mauck RJ; Department of Urology, and UT Southwestern Medical Center, Dallas, Texas, USA., Roehrborn CG; Department of Urology, and UT Southwestern Medical Center, Dallas, Texas, USA., Strand DW; Department of Urology, and UT Southwestern Medical Center, Dallas, Texas, USA., Costa DN; Department of Radiology, UT Southwestern Medical Center, Dallas, Texas, USA., Gahan JC; Department of Urology, and UT Southwestern Medical Center, Dallas, Texas, USA. |
| المصدر: | Journal of endourology [J Endourol] 2022 Mar; Vol. 36 (3), pp. 381-386. Date of Electronic Publication: 2022 Feb 28. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8807503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-900X (Electronic) Linking ISSN: 08927790 NLM ISO Abbreviation: J Endourol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Mary Ann Liebert, [c1987- |
| مواضيع طبية MeSH: | Prostatic Hyperplasia*/surgery , Prostatic Neoplasms*/surgery, Humans ; Magnetic Resonance Imaging/methods ; Male ; Prostate/diagnostic imaging ; Prostate/pathology ; Retrospective Studies |
| مستخلص: | Background: Histologic phenotypic variation of benign prostatic hyperplasia (BPH) has been hypothesized to underlie response to medical therapy. We evaluate preoperative MRI of robot-assisted simple prostatectomy (RASP) specimens and determine imaging features associated with histologic phenotype. Materials and Methods: All patients undergoing RASP from November 2015 to November 2019 with a multiparametric MRI ≤1 year before RASP were included. Patients without identifiable BPH nodules on histologic specimens were excluded. Histology slides were obtained from whole mount adenoma specimens and corresponding MRI were reviewed and graded independently by a blinded expert in BPH histopathology (D.W.S.) and an experienced radiologist specializing in prostate imaging (D.N.C.), respectively. Each nodule was assigned a phenotypic score on a 5-point Likert scale (1 = predominantly glandular; 5 = predominantly stromal) by each reviewer. Scores were compared using the sign test and univariate analysis. Signal intensity relative to background transition zone and nodule texture were noted on T2, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging sequences. Univariate and multivariate stepwise linear regression analysis were conducted to identify MRI features associated with histology score. All analyses were performed using Statistical Analysis System (version 9.4). Results: A total of 99 prostate nodules in 29 patients were included. Median phenotypic scores by histology and MRI were comparable (2, interquartile range [IQR] 2-3 vs 2, IQR 2-4, respectively; p = 0.63). Histology scores were positively correlated with MRI scores (Pearson's correlation 0.84, p < 0.0001). Multivariate stepwise linear regression analysis showed that low apparent diffusion coefficient (ADC) signal intensity ( p < 0.001) and DCE wash-in ( p = 0.03) were positively associated with more stromal histology, whereas ADC standard deviation ( p = 0.03), DCE wash-out ( p = 0.001), and heterogeneous T2 texture ( p = 0.003) were associated with more glandular histology. Conclusion: There is a strong correlation between MRI features and the histologic phenotype of BPH nodules. MRI may provide a noninvasive method to determine underlying BPH nodule histology. |
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| معلومات مُعتمدة: | U54 DK104310 United States DK NIDDK NIH HHS; R01 DK115477 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: MRI; benign prostatic hyperplasia; histology; lower urinary tract symptoms |
| تواريخ الأحداث: | Date Created: 20210922 Date Completed: 20220405 Latest Revision: 20230302 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8972022 |
| DOI: | 10.1089/end.2021.0397 |
| PMID: | 34549591 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-900X |
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| DOI: | 10.1089/end.2021.0397 |