دورية أكاديمية
PhotothermalPhage: A Virus-Based Photothermal Therapeutic Agent.
| العنوان: | PhotothermalPhage: A Virus-Based Photothermal Therapeutic Agent. |
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| المؤلفون: | Shahrivarkevishahi A; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Luzuriaga MA; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Herbert FC; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Tumac AC; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Brohlin OR; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Wijesundara YH; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Adlooru AV; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Benjamin C; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Lee H; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Parsamian P; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Gadhvi J; Department of Biological Sciences, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., De Nisco NJ; Department of Biological Sciences, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States., Gassensmith JJ; Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States.; Department of Bioengineering, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States. |
| المصدر: | Journal of the American Chemical Society [J Am Chem Soc] 2021 Oct 13; Vol. 143 (40), pp. 16428-16438. Date of Electronic Publication: 2021 Sep 22. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc |
| أسماء مطبوعة: | Publication: Washington, DC : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مواضيع طبية MeSH: | Photothermal Therapy*, Animals ; Mice ; Humans ; Infrared Rays ; Allolevivirus/chemistry ; Cell Line, Tumor |
| مستخلص: | Virus-like particles (VLPs) are multifunctional nanocarriers that mimic the architecture of viruses. They can serve as a safe platform for specific functionalization and immunization, which provides benefits in a wide range of biomedical applications. In this work, a new generation immunophotothermal agent is developed that adjuvants photothermal ablation using a chemically modified VLP called bacteriophage Qβ. The design is based on the conjugation of near-infrared absorbing croconium dyes to lysine residues located on the surface of Qβ, which turns it to a powerful NIR-absorber called PhotothermalPhage. This system can generate more heat upon 808 nm NIR laser radiation than free dye and possesses a photothermal efficiency comparable to gold nanostructures, yet it is biodegradable and acts as an immunoadjuvant combined with the heat it produces. The synergistic combination of thermal ablation with the mild immunogenicity of the VLP leads to effective suppression of primary tumors, reduced lung metastasis, and increased survival time. |
| تواريخ الأحداث: | Date Created: 20210922 Date Completed: 20240724 Latest Revision: 20240724 |
| رمز التحديث: | 20240726 |
| DOI: | 10.1021/jacs.1c05090 |
| PMID: | 34551259 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5126 |
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| DOI: | 10.1021/jacs.1c05090 |