دورية أكاديمية
Arsenic and other metals as phenotype driving electrophiles in carcinogenesis.
| العنوان: | Arsenic and other metals as phenotype driving electrophiles in carcinogenesis. |
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| المؤلفون: | Danes JM; Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, United States., Palma FR; Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, United States., Bonini MG; Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Chicago, United States. Electronic address: marcelo.bonini@northwestern.edu. |
| المصدر: | Seminars in cancer biology [Semin Cancer Biol] 2021 Nov; Vol. 76, pp. 287-291. Date of Electronic Publication: 2021 Sep 23. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 9010218 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3650 (Electronic) Linking ISSN: 1044579X NLM ISO Abbreviation: Semin Cancer Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Academic Press Original Publication: Philadelphia, PA, USA : Saunders Scientific Publications, W.B. Saunders Co., c1990- |
| مواضيع طبية MeSH: | Arsenic/*adverse effects , Cadmium/*adverse effects , Carcinogenesis/*chemically induced, Animals ; Humans ; Phenotype |
| مستخلص: | There are several sources of heavy metal exposures whether occupational or environmental. These are connected both with the existence of natural reservoirs of metal toxicants or human activity such as mining, welding and construction. In general, exposure to heavy metals, such as cadmium (Cd), mercury (Hg), nickel (Ni), lead (Pb) and metalloids, such as arsenic (As), has been associated with diseases including neurodegenerative diseases, diabetes and cancer. Common to these diseases is the loss of cellular physiologic performance and phenotype required for proper function. On the metal side, electrophilic behavior that disrupts the electronic (or redox) state of cells is a common feature. This suggests that there may be a connection between changes to the redox equilibrium of cells caused by environmental exposures to heavy metals and the pathogenic effects of such exposures. In this mini-review, we will focus on two environmental contaminants cadmium (a metal) and arsenic (a metalloid) and explore their interactions with living organisms from the perspective of their electrophilic chemical reactivity that underlies both their potential as carcinogens and as drivers of more aggressive tumor phenotypes. (Copyright © 2021. Published by Elsevier Ltd.) |
| معلومات مُعتمدة: | R01 AI131267 United States AI NIAID NIH HHS; R01 CA216882 United States CA NCI NIH HHS; R01 ES028149 United States ES NIEHS NIH HHS |
| فهرسة مساهمة: | Keywords: Arsenic; Breast cancer; Electrophiles; Epithelial; Mesenchymal |
| المشرفين على المادة: | 00BH33GNGH (Cadmium) N712M78A8G (Arsenic) |
| تواريخ الأحداث: | Date Created: 20210926 Date Completed: 20220303 Latest Revision: 20220303 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.semcancer.2021.09.012 |
| PMID: | 34563651 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1096-3650 |
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| DOI: | 10.1016/j.semcancer.2021.09.012 |