دورية أكاديمية
Isolation of Sesquiterpenoids and Steroids from the Soft Coral Sinularia brassica and Determination of Their Absolute Configuration.
العنوان: | Isolation of Sesquiterpenoids and Steroids from the Soft Coral Sinularia brassica and Determination of Their Absolute Configuration. |
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المؤلفون: | Pham GN; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea., Kang DY; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea., Kim MJ; Division of Life Sciences, Korea Polar Research Institute, Incheon 21990, Korea., Han SJ; Division of Life Sciences, Korea Polar Research Institute, Incheon 21990, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon 21990, Korea., Lee JH; Department of Polar Sciences, University of Science and Technology, Incheon 21990, Korea.; Research Unit of Cryogenic Novel Material, Korea Polar Research Institute, Incheon 21990, Korea., Na M; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. |
المصدر: | Marine drugs [Mar Drugs] 2021 Sep 17; Vol. 19 (9). Date of Electronic Publication: 2021 Sep 17. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2003]- |
مواضيع طبية MeSH: | Anthozoa*, Anti-Bacterial Agents/*chemistry , Antiprotozoal Agents/*chemistry , Sesquiterpenes/*chemistry , Steroids/*chemistry, Animals ; Anti-Bacterial Agents/pharmacology ; Antiprotozoal Agents/pharmacology ; Candida albicans/drug effects ; Escherichia coli/drug effects ; Leishmania donovani/drug effects ; Magnetic Resonance Spectroscopy ; Sesquiterpenes/pharmacology ; Staphylococcus aureus/drug effects ; Steroids/pharmacology ; Structure-Activity Relationship |
مستخلص: | Two undescribed rearranged cadinane-type sesquiterpenoids ( 1 - 2 ), named sinulaketol A-B, together with one new chlorinated steroid ( 3 ), one new gorgosterol ( 4 ), one known sesquiterpene ( 5 ), one known dibromoditerpene ( 6 ) and two known polyhydroxylated steroids ( 7 - 8 ) were isolated from the soft coral Sinularia brassica . The structures of these compounds were established by extensive spectroscopic analysis, including HRESIMS, 1D, and 2D NMR spectroscopy. Their absolute configurations were also determined by the ECD calculations and DP4+ probability analysis. Antileishmanial activity of compounds 1 - 8 was evaluated in vitro against the amastigote forms of Leishmania donovani , in which compounds 3 , 6 , and 7 inhibited the growth of L. donovani by 58.7, 74.3, 54.7%, respectively, at a concentration of 50 μM. Antimicrobial effect of the isolated compounds were also evaluated against Candida albicans , Staphylococcus aureus , and Escherichia coli. Compound 6 , a brominated diterpene, exhibited antimicrobial effect against S . aureus . |
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معلومات مُعتمدة: | 15250103, PM21030 Korea Polar Research Institute |
فهرسة مساهمة: | Keywords: Sinularia brassica; antileishmanial activity; antimicrobial activity; sesquiterpenoids; steroids |
المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Antiprotozoal Agents) 0 (Sesquiterpenes) 0 (Steroids) |
تواريخ الأحداث: | Date Created: 20210926 Date Completed: 20220117 Latest Revision: 20240403 |
رمز التحديث: | 20240403 |
مُعرف محوري في PubMed: | PMC8466225 |
DOI: | 10.3390/md19090523 |
PMID: | 34564185 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1660-3397 |
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DOI: | 10.3390/md19090523 |