دورية أكاديمية
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Isolation of Sesquiterpenoids and Steroids from the Soft Coral Sinularia brassica and Determination of Their Absolute Configuration.

التفاصيل البيبلوغرافية
العنوان: Isolation of Sesquiterpenoids and Steroids from the Soft Coral Sinularia brassica and Determination of Their Absolute Configuration.
المؤلفون: Pham GN; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea., Kang DY; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea., Kim MJ; Division of Life Sciences, Korea Polar Research Institute, Incheon 21990, Korea., Han SJ; Division of Life Sciences, Korea Polar Research Institute, Incheon 21990, Korea.; Department of Polar Sciences, University of Science and Technology, Incheon 21990, Korea., Lee JH; Department of Polar Sciences, University of Science and Technology, Incheon 21990, Korea.; Research Unit of Cryogenic Novel Material, Korea Polar Research Institute, Incheon 21990, Korea., Na M; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.
المصدر: Marine drugs [Mar Drugs] 2021 Sep 17; Vol. 19 (9). Date of Electronic Publication: 2021 Sep 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Anthozoa*, Anti-Bacterial Agents/*chemistry , Antiprotozoal Agents/*chemistry , Sesquiterpenes/*chemistry , Steroids/*chemistry, Animals ; Anti-Bacterial Agents/pharmacology ; Antiprotozoal Agents/pharmacology ; Candida albicans/drug effects ; Escherichia coli/drug effects ; Leishmania donovani/drug effects ; Magnetic Resonance Spectroscopy ; Sesquiterpenes/pharmacology ; Staphylococcus aureus/drug effects ; Steroids/pharmacology ; Structure-Activity Relationship
مستخلص: Two undescribed rearranged cadinane-type sesquiterpenoids ( 1 - 2 ), named sinulaketol A-B, together with one new chlorinated steroid ( 3 ), one new gorgosterol ( 4 ), one known sesquiterpene ( 5 ), one known dibromoditerpene ( 6 ) and two known polyhydroxylated steroids ( 7 - 8 ) were isolated from the soft coral Sinularia brassica . The structures of these compounds were established by extensive spectroscopic analysis, including HRESIMS, 1D, and 2D NMR spectroscopy. Their absolute configurations were also determined by the ECD calculations and DP4+ probability analysis. Antileishmanial activity of compounds 1 - 8 was evaluated in vitro against the amastigote forms of Leishmania donovani , in which compounds 3 , 6 , and 7 inhibited the growth of L. donovani by 58.7, 74.3, 54.7%, respectively, at a concentration of 50 μM. Antimicrobial effect of the isolated compounds were also evaluated against Candida albicans , Staphylococcus aureus , and Escherichia coli. Compound 6 , a brominated diterpene, exhibited antimicrobial effect against S . aureus .
References: J Org Chem. 2015 Dec 18;80(24):12526-34. (PMID: 26580165)
Mar Drugs. 2021 Jun 11;19(6):. (PMID: 34208171)
Steroids. 2001 Dec;66(12):897-904. (PMID: 11711118)
Chem Pharm Bull (Tokyo). 2016 Sep 1;64(9):1417-9. (PMID: 27321426)
Steroids. 1976 Oct;28(4):461-6. (PMID: 12598)
J Enzyme Inhib Med Chem. 2021 Dec;36(1):1922-1930. (PMID: 34425714)
Steroids. 2005 Dec 1;70(13):886-95. (PMID: 16038957)
Arch Pharm Res. 2012 May;35(5):779-84. (PMID: 22644845)
J Asian Nat Prod Res. 2017 Dec;19(12):1183-1190. (PMID: 28421816)
Nat Prod Rep. 2009 Feb;26(2):170-244. (PMID: 19177222)
Antimicrob Agents Chemother. 1990 Nov;34(11):2075-80. (PMID: 2127342)
Nat Prod Res. 2009;23(9):801-50. (PMID: 19488923)
Phytochemistry. 2017 Jan;133:45-50. (PMID: 27816176)
Mar Drugs. 2013 Sep 30;11(10):3735-41. (PMID: 24084789)
Nat Prod Res. 2017 Aug;31(15):1799-1804. (PMID: 28278636)
J Nat Prod. 2004 Oct;67(10):1650-3. (PMID: 15497934)
Arch Pharm Res. 2016 Jun;39(6):778-84. (PMID: 27230778)
J Nat Prod. 2013 Oct 25;76(10):1902-8. (PMID: 24128077)
Mar Drugs. 2012 Jul;10(7):1422-1432. (PMID: 22851916)
معلومات مُعتمدة: 15250103, PM21030 Korea Polar Research Institute
فهرسة مساهمة: Keywords: Sinularia brassica; antileishmanial activity; antimicrobial activity; sesquiterpenoids; steroids
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Antiprotozoal Agents)
0 (Sesquiterpenes)
0 (Steroids)
تواريخ الأحداث: Date Created: 20210926 Date Completed: 20220117 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC8466225
DOI: 10.3390/md19090523
PMID: 34564185
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md19090523