دورية أكاديمية
Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes.
| العنوان: | Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes. |
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| المؤلفون: | Omoumi P; Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Department of Diagnostic and Interventional Radiology, Lausanne, Switzerland; Cliniques Universitaires St Luc - UC Louvain, Department of Radiology, Brussels, Belgium. Electronic address: patrick.omoumi@chuv.ch., Schuler A; Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Department of Musculoskeletal Medicine, Swiss BioMotion Lab, Lausanne, Switzerland., Babel H; Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Department of Musculoskeletal Medicine, Swiss BioMotion Lab, Lausanne, Switzerland., Stoffel C; Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Department of Musculoskeletal Medicine, Swiss BioMotion Lab, Lausanne, Switzerland., Jolles BM; Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Department of Musculoskeletal Medicine, Swiss BioMotion Lab, Lausanne, Switzerland; Ecole Polytechnique Fédérale Lausanne (EPFL), Institute of Microengineering, Lausanne, Switzerland., Favre J; Ecole Polytechnique Fédérale Lausanne (EPFL), Institute of Microengineering, Lausanne, Switzerland. |
| المصدر: | Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2021 Dec; Vol. 29 (12), pp. 1691-1700. Date of Electronic Publication: 2021 Sep 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9653 (Electronic) Linking ISSN: 10634584 NLM ISO Abbreviation: Osteoarthritis Cartilage Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : W.B. Saunders For The Osteoarthritis Research Society Original Publication: London : Published for the Society by Baillère Tindall, c1993- |
| مواضيع طبية MeSH: | Knee Joint/*diagnostic imaging , Osteoarthritis, Knee/*diagnostic imaging , Osteophyte/*diagnostic imaging, Aged ; Computer Simulation ; Cross-Sectional Studies ; Female ; Humans ; Imaging, Three-Dimensional ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Tomography, X-Ray Computed |
| مستخلص: | Objective: To characterize the differences and correlations in osteophyte volumes between and within proximal tibial compartments, and to assess the correlations between osteophyte volumes and the femorotibial angle. Design: CT scans of 73 knees with predominantly medial femorotibial osteoarthritis (21 K/L2, 28 K/L3, 24 K/L4) were retrospectively analyzed using a new, reproducible method measuring total and subregional osteophyte volumes in the medial and lateral compartments. Non-parametric statistics was used for comparison and correlation analyses. Results: Total osteophyte volumes were larger in the medial than in the lateral compartment for all severity groups (p < 0.05). Additionally, statistically significant differences were observed among subregions of the lateral compartment in K/L3 and K/L4 knees. Statistically significant positive correlations were found between the medial and lateral total osteophyte volumes in K/L3 and K/L4 knees (ρ ≥ 0.44, p = 0.03), and among most subregional osteophyte volumes within each compartment in K/L3 knees. Markedly fewer statistically significant correlations were present in K/L2 and K/L4 knees. In K/L3 knees, the femorotibial angle was statistically significantly positively correlated with the total osteophyte volume in the medial compartment (ρ = 0.50, p = 0.01), with osteophyte volumes in most medial subregions, and with the osteophyte volume in the lateral posterior subregion (ρ = 0.40, p = 0.05). Conclusions: Quantitative assessment of osteophytes may bring insight on factors influencing their development. Positive correlations of osteophyte volumes found between and within compartments suggest the influence of biochemical mediators acting on the entire joint, while positive correlations between the femorotibial angle and osteophyte volumes suggest a role of mechanical factors. These hypotheses are to be further confirmed. (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Knee; Osteoarthritis; Osteophyte; Segmentation; Topography; X-ray computed tomography |
| تواريخ الأحداث: | Date Created: 20210927 Date Completed: 20220302 Latest Revision: 20220302 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.joca.2021.09.008 |
| PMID: | 34571138 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1522-9653 |
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| DOI: | 10.1016/j.joca.2021.09.008 |