دورية أكاديمية
Investigation of powerful fungicidal activity of tetra-cationic platinum(II) and palladium(II) porphyrins by antimicrobial photodynamic therapy assays.
| العنوان: | Investigation of powerful fungicidal activity of tetra-cationic platinum(II) and palladium(II) porphyrins by antimicrobial photodynamic therapy assays. |
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| المؤلفون: | Pinto SC; Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia - LAPEMI, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., Acunha TV; Laboratório de Bioinorgânica e Materiais Porfirínicos (LBMP), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., Santurio JM; Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia - LAPEMI, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., Denardi LB; Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia - LAPEMI, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., Iglesias BA; Laboratório de Bioinorgânica e Materiais Porfirínicos (LBMP), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil. Electronic address: bernardo.iglesias@ufsm.br. |
| المصدر: | Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2021 Dec; Vol. 36, pp. 102550. Date of Electronic Publication: 2021 Sep 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101226123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1597 (Electronic) Linking ISSN: 15721000 NLM ISO Abbreviation: Photodiagnosis Photodyn Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; Boston : Elsevier, c2004- |
| مواضيع طبية MeSH: | Anti-Infective Agents* , Photochemotherapy*/methods , Porphyrins*/pharmacology, Palladium ; Photosensitizing Agents/pharmacology ; Platinum |
| مستخلص: | This manuscript reports enhanced antimicrobial photoinactivation using tetra-cationic porphyrins with peripheral platinum(II) and palladium(II) complexes against fungal dermatophyte strains. Six different positively charged porphyrins were used and applied in antimicrobial photodynamic therapy experiments (aPDT) against dermatophyte fungi colonies. The microbiological tests were conducted with an adequate concentration of photosensitizer (PS) under white-light irradiation for 120 min and the most effective PS meta isomer 3PtP significantly reduced the concentration of viable fungal colony. In this way, tetra-cationic porphyrins containing platinum(II)-bipyridyl complexes may be promising fungicidal aPDT agents with potential applications in future clinical cases. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antifungal therapy; Antimicrobial activity; Cationic porphyrins; Pd(II)-porphyrins; Photodynamic therapy; Porphyrins; Pt(II)-porphyrins |
| المشرفين على المادة: | 0 (Anti-Infective Agents) 0 (Photosensitizing Agents) 0 (Porphyrins) 49DFR088MY (Platinum) 5TWQ1V240M (Palladium) |
| تواريخ الأحداث: | Date Created: 20210927 Date Completed: 20211209 Latest Revision: 20211214 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.pdpdt.2021.102550 |
| PMID: | 34571273 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-1597 |
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| DOI: | 10.1016/j.pdpdt.2021.102550 |