دورية أكاديمية
أعرض في EDS

HIV Increases the Inhibitory Impact of Morphine and Antiretrovirals on Autophagy in Primary Human Macrophages: Contributions to Neuropathogenesis.

التفاصيل البيبلوغرافية
العنوان: HIV Increases the Inhibitory Impact of Morphine and Antiretrovirals on Autophagy in Primary Human Macrophages: Contributions to Neuropathogenesis.
المؤلفون: Barbaro JM; Montefiore Medical Center, Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA., Cuervo AM; Montefiore Medical Center, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA., Berman JW; Montefiore Medical Center, Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.; Montefiore Medical Center, Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
المصدر: Cells [Cells] 2021 Aug 24; Vol. 10 (9). Date of Electronic Publication: 2021 Aug 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Anti-Retroviral Agents/*pharmacology , Autophagy/*drug effects , HIV Infections/*drug therapy , Macrophages/*drug effects , Morphine/*pharmacology , Neurocognitive Disorders/*drug therapy, Cells, Cultured ; HIV Infections/virology ; HIV-1/pathogenicity ; Humans ; Mitophagy/drug effects ; Neurocognitive Disorders/virology
مستخلص: HIV enters the CNS early after peripheral infection, establishing reservoirs in perivascular macrophages that contribute to development of HIV-associated neurocognitive disorders (HAND) in 15-40% of people with HIV (PWH) despite effective antiretroviral therapy (ART). Opioid use may contribute to dysregulated macrophage functions resulting in more severe neurocognitive symptoms in PWH taking opioids. Macroautophagy helps maintain quality control in long-lived cell types, such as macrophages, and has been shown to regulate, in part, some macrophage functions in the CNS that contribute to HAND. Using Western blotting and confocal immunofluorescence in primary human macrophages, we demonstrated that morphine and a commonly prescribed ART regimen induce bulk autophagy. Morphine and ART also inhibited completion of autophagy. HIV infection increased these inhibitory effects. We also examined two types of selective autophagy that degrade aggregated proteins (aggrephagy) and dysfunctional mitochondria (mitophagy). Morphine and ART inhibited selective autophagy mediated by p62 regardless of HIV infection, and morphine inhibited mitophagic flux in HIV-infected cells demonstrating potential mitotoxicity. These results indicate that inhibition of autophagy, both in bulk and selective, in CNS macrophages may mediate neurocognitive dysfunction in PWH using opioids. Increasing autophagic activity in the context of HIV may represent a novel therapeutic strategy for reducing HAND in these individuals.
References: Autophagy. 2010 Apr;6(3):386-94. (PMID: 20190558)
mBio. 2021 Mar 16;12(2):. (PMID: 33727362)
Acta Pharmacol Sin. 2013 May;34(5):625-35. (PMID: 23524572)
Front Cell Dev Biol. 2021 Apr 09;9:656370. (PMID: 33898457)
J Neuroinflammation. 2012 Aug 18;9:203. (PMID: 22901451)
Immunity. 2013 Sep 19;39(3):537-47. (PMID: 24035364)
Front Immunol. 2014 Oct 07;5:491. (PMID: 25339958)
J Neuroimmune Pharmacol. 2019 Mar;14(1):110-119. (PMID: 30194646)
J Cell Biol. 2009 Jul 27;186(2):255-68. (PMID: 19635843)
EMBO J. 2017 Jun 14;36(12):1688-1706. (PMID: 28465321)
Front Neurol. 2020 Sep 04;11:840. (PMID: 33013619)
Ann Pharmacother. 2010 May;44(5):838-43. (PMID: 20371753)
Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):86-96. (PMID: 16433897)
J Innate Immun. 2015;7(4):375-91. (PMID: 25764971)
Clin Pharmacol Ther. 2001 Sep;70(3):237-46. (PMID: 11557911)
Nat Rev Neurol. 2016 Apr;12(4):234-48. (PMID: 26965674)
Brain Behav Immun. 2012 Mar;26(3):480-8. (PMID: 22240038)
J Cell Biol. 2010 Apr 19;189(2):211-21. (PMID: 20404107)
Antioxid Redox Signal. 2021 Mar 1;34(7):517-530. (PMID: 32079408)
Curr Clin Pharmacol. 2006 Jan;1(1):109-18. (PMID: 18666382)
Front Microbiol. 2015 Jul 06;6:653. (PMID: 26217309)
Antimicrob Agents Chemother. 2018 Dec 21;63(1):. (PMID: 30373793)
J Acquir Immune Defic Syndr. 2013 May 1;63(1):67-76. (PMID: 23392462)
Antivir Ther. 2007;12(4):489-500. (PMID: 17668557)
Nat Cell Biol. 2010 Mar;12(3):213-23. (PMID: 20173742)
J Infect Dis. 2011 Jun 1;203(11):1647-57. (PMID: 21592995)
Nat Immunol. 2011 Mar;12(3):222-30. (PMID: 21151103)
EMBO J. 2017 Jul 3;36(13):1811-1836. (PMID: 28596378)
J Investig Med. 2002 Nov;50(6):435-42. (PMID: 12425430)
Neurobiol Dis. 2011 Jul;43(1):38-45. (PMID: 21296668)
J Virol. 2015 Jan 15;89(2):1024-35. (PMID: 25355898)
mBio. 2020 Jul 28;11(4):. (PMID: 32723919)
Viruses. 2017 Sep 23;9(10):. (PMID: 28946621)
J Neurovirol. 2015 Jun;21(3):235-41. (PMID: 25933548)
Autophagy. 2020 Feb;16(2):223-238. (PMID: 30982401)
Brain Res. 2019 Dec 1;1724:146426. (PMID: 31473221)
Toxicol Lett. 2018 Mar 1;284:120-128. (PMID: 29241732)
Acta Physiol (Oxf). 2015 Jun;214(2):189-199. (PMID: 25850855)
Exp Cell Res. 2002 Nov 1;280(2):192-200. (PMID: 12413885)
JAMA. 2020 Oct 27;324(16):1674-1677. (PMID: 32945855)
Clin Exp Immunol. 2017 Jan;187(1):44-52. (PMID: 27198731)
AIDS. 2011 Jul 17;25(11):1385-94. (PMID: 21505312)
J Immunol. 2012 Apr 15;188(8):3757-65. (PMID: 22430735)
Cell Death Differ. 2011 Apr;18(4):571-80. (PMID: 21311563)
Neurobiol Dis. 2019 Feb;122:16-22. (PMID: 30149183)
Antimicrob Agents Chemother. 2011 Sep;55(9):4090-5. (PMID: 21746959)
J Neurovirol. 2014 Feb;20(1):39-53. (PMID: 24420448)
AIDS Patient Care STDS. 2009 Jun;23(6):455-62. (PMID: 19519229)
J Virol. 2019 Aug 28;93(18):. (PMID: 31270227)
Brain. 2008 Aug;131(Pt 8):1969-78. (PMID: 18187492)
Clin Microbiol Rev. 2013 Jan;26(1):2-18. (PMID: 23297256)
J Neuroimmune Pharmacol. 2017 Jun;12(2):353-370. (PMID: 28133717)
PLoS One. 2013 Oct 25;8(10):e78814. (PMID: 24205323)
Mol Cells. 2018 Jan 31;41(1):18-26. (PMID: 29370689)
Nat Rev Immunol. 2018 Apr;18(4):225-242. (PMID: 29151590)
Oncotarget. 2017 Jun 20;8(25):40817-40831. (PMID: 28489580)
PLoS Pathog. 2015 Jun 26;11(6):e1005018. (PMID: 26115100)
J Clin Invest. 2021 Apr 1;131(7):. (PMID: 33661763)
Pediatr Res. 2003 Aug;54(2):282-8. (PMID: 12736382)
Cells. 2021 Apr 15;10(4):. (PMID: 33920955)
Autophagy. 2021 Jan;17(1):1-382. (PMID: 33634751)
Front Med. 2018 Dec;12(6):697-706. (PMID: 30421395)
J Neurochem. 2013 Dec;127(5):644-51. (PMID: 23992092)
J Mol Biol. 2020 Apr 3;432(8):2799-2821. (PMID: 31887286)
Mol Brain. 2009 Sep 16;2:29. (PMID: 19754977)
Neurobiol Dis. 2011 Jul;43(1):60-7. (PMID: 20969957)
J Clin Exp Neuropsychol. 2010 Jul;32(6):579-89. (PMID: 19890760)
J Infect Dis. 2012 Jul 15;206(2):275-82. (PMID: 22551810)
J Anim Sci Biotechnol. 2021 Mar 9;12(1):35. (PMID: 33685494)
Sci Rep. 2017 Mar 24;7(1):393. (PMID: 28341848)
Cancer Res. 1977 May;37(5):1401-7. (PMID: 558047)
Cells. 2019 Sep 28;8(10):. (PMID: 31569373)
Int Rev Neurobiol. 2014;118:231-313. (PMID: 25175867)
Autophagy. 2009 Jul;5(5):585-9. (PMID: 19411822)
Cells. 2020 Jun 09;9(6):. (PMID: 32526847)
J Leukoc Biol. 2017 Nov;102(5):1173-1185. (PMID: 28754798)
J Cell Biol. 2019 Mar 4;218(3):757-770. (PMID: 30578282)
Autophagy. 2014 Jul;10(7):1167-78. (PMID: 24813622)
Essays Biochem. 2017 Dec 12;61(6):609-624. (PMID: 29233872)
PLoS One. 2012;7(2):e31167. (PMID: 22359571)
J Acquir Immune Defic Syndr. 2011 Oct 1;58(2):154-62. (PMID: 21725250)
Eur Rev Med Pharmacol Sci. 2017 May;21(9):2290-2301. (PMID: 28537651)
Autophagy. 2011 Mar;7(3):279-96. (PMID: 21189453)
Front Immunol. 2019 Oct 18;10:2445. (PMID: 31681322)
Nat Immunol. 2012 Jan 29;13(3):255-63. (PMID: 22286270)
معلومات مُعتمدة: 5R01DA044584 United States NH NIH HHS; 5T32GM007288-44 United States NH NIH HHS; 2T32AI070117-13 United States NH NIH HHS; 5R01DA048609 United States NH NIH HHS; R01 DA044584 United States DA NIDA NIH HHS; P30 AG038072 United States AG NIA NIH HHS; F30 DA053118 United States DA NIDA NIH HHS; T32 GM007288 United States GM NIGMS NIH HHS; R01 DA048609 United States DA NIDA NIH HHS; P30 AI124414 United States AI NIAID NIH HHS; T32 AI070117 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: HIV-associated neurocognitive disorders; LC3; antiretroviral therapy; autophagy; mitophagy; myeloid cells; opioids; p62/SQSTM1; selective autophagy
المشرفين على المادة: 0 (Anti-Retroviral Agents)
76I7G6D29C (Morphine)
تواريخ الأحداث: Date Created: 20210928 Date Completed: 20211119 Latest Revision: 20220518
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8470112
DOI: 10.3390/cells10092183
PMID: 34571832
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells10092183