دورية أكاديمية
أعرض في EDS

Maternal Under- and Over-Nutrition during Gestation Causes Islet Hypertrophy and Sex-Specific Changes to Pancreas DNA Methylation in Fetal Sheep.

التفاصيل البيبلوغرافية
العنوان: Maternal Under- and Over-Nutrition during Gestation Causes Islet Hypertrophy and Sex-Specific Changes to Pancreas DNA Methylation in Fetal Sheep.
المؤلفون: Peterson M; Department of Fisheries, Animal and Veterinary Science, University of Rhode Island, Kingston, RI 02891, USA.; Department of Animal Science, University of Connecticut, Storrs, CT 06289, USA., Gauvin M; Department of Animal Science, University of Connecticut, Storrs, CT 06289, USA., Pillai S; Department of Animal Science, University of Connecticut, Storrs, CT 06289, USA., Jones A; Department of Animal Science, University of Connecticut, Storrs, CT 06289, USA., McFadden K; Department of Animal Science, University of Connecticut, Storrs, CT 06289, USA., Cameron K; Department of Animal Science, University of Connecticut, Storrs, CT 06289, USA., Reed S; Department of Animal Science, University of Connecticut, Storrs, CT 06289, USA., Zinn S; Department of Animal Science, University of Connecticut, Storrs, CT 06289, USA., Govoni K; Department of Animal Science, University of Connecticut, Storrs, CT 06289, USA.
المصدر: Animals : an open access journal from MDPI [Animals (Basel)] 2021 Aug 28; Vol. 11 (9). Date of Electronic Publication: 2021 Aug 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Molecular Diversity Preservation International Country of Publication: Switzerland NLM ID: 101635614 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2615 (Print) Linking ISSN: 20762615 NLM ISO Abbreviation: Animals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2011-
مستخلص: The mechanisms by which fetal programming predisposes offspring to reduced β-cell function later in life are poorly understood. We hypothesized that maternal under- and over-nutrition during gestation would negatively affect offspring pancreas development and alter DNA methylation patterns. Pregnant ewes ( n = 78) were fed 100, 60, or 140% of NRC requirements beginning at d 30.2 ± 0.2 of gestation. The fetuses are referred to as CON, RES, and OVER, respectively. Fetal pancreas tissue was collected at d 90 or 135 of gestation or within 24 h of birth. Tissue was preserved for histological ( n = 8 to 9 offspring per treatment per time point) and DNA methylation analyses ( n = 3 to 4 fetuses per treatment per sex). At d 135, OVER exhibited an increased islet size, reduced islet number, and greater insulin positive area compared with CON ( p ≤ 0.03). An increased islet size was also observed at d 135 in RES ( p ≤ 0.03) compared with CON. Cellular proliferation was reduced at birth in OVER vs. CON ( p = 0.01). In the RES vs. CON females, 62% of the differentially methylated regions (DMRs) were hypomethylated ( p ≤ 0.001). In the RES vs. CON males, 93% of the DMRs were hypermethylated ( p ≤ 0.001). In OVER, 66 and 80% of the DMRs were hypermethylated in the female and male offspring compared with CON ( p ≤ 0.001). In conclusion, changes to maternal diet during pregnancy affects the islet hypertrophy and cellular proliferation of the offspring at early post-natal time points. Additionally, changes in DNA methylation patterns appear to be in a diet-specific and sex-dependent manner.
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معلومات مُعتمدة: USDA-AFRI-NIFA 2013-01919 U.S. Department of Agriculture; USDA-AFRI-NIFA 2014-01982 U.S. Department of Agriculture
فهرسة مساهمة: Keywords: DNA methylation; beta cell function; endocrine pancreas; fetal programming; sheep
تواريخ الأحداث: Date Created: 20210928 Latest Revision: 20211001
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8466738
DOI: 10.3390/ani11092531
PMID: 34573497
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2615
DOI:10.3390/ani11092531