دورية أكاديمية
أعرض في EDS

Evidence of possible SARS-CoV-2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women.

التفاصيل البيبلوغرافية
العنوان: Evidence of possible SARS-CoV-2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women.
المؤلفون: Sevilla-Montoya R; Department of Genetics and Human Genomics, National Institute of Perinatology, Mexico City, Mexico., Hidalgo-Bravo A; Department of Genetics and Genomic Medicine, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico City, Mexico., Estrada-Gutiérrez G; Dirección de Investigación, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico., Villavicencio-Carrisoza O; Departamento de Inmuno-Bioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico.; Programa de posgrado en Biomedicina y Biotecnología Molecular, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Mexico City, Mexico., Leon-Juarez M; Departamento de Inmuno-Bioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico., Villegas-Mota I; Unidad de enfermedades infecciosas y epidemiología, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico., Espino-Y-Sosa S; Subdirección de Investigación Clínica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico., Monroy-Muñoz IE; Department of Genetics and Human Genomics, National Institute of Perinatology, Mexico City, Mexico., Martinez-Portilla RJ; Subdirección de Investigación Clínica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico., Poon LC; Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR., Cardona-Pérez JA; Dirección General, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico., Helguera-Repetto AC; Departamento de Inmuno-Bioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico.
مؤلفون مشاركون: Collaborators
المصدر: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology [Ultrasound Obstet Gynecol] 2021 Dec; Vol. 58 (6), pp. 900-908.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: England NLM ID: 9108340 Publication Model: Print Cited Medium: Internet ISSN: 1469-0705 (Electronic) Linking ISSN: 09607692 NLM ISO Abbreviation: Ultrasound Obstet Gynecol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : Chichester, West Sussex, UK : John Wiley & Sons, Ltd.
Original Publication: Carnforth, Lancs, UK ; Park Ridge, N.J., USA : Parthenon Pub., c1991-
مواضيع طبية MeSH: Infectious Disease Transmission, Vertical*, COVID-19/*transmission, Adult ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Nucleic Acid Testing ; Cesarean Section ; Cohort Studies ; Female ; Humans ; Infant, Newborn ; Mexico/epidemiology ; Middle Aged ; Neonatal Screening ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/pathogenicity
مستخلص: Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vertical transmission has been investigated extensively. Recently, the World Health Organization (WHO) published strict criteria to classify the timing of mother-to-child transmission of SARS-CoV-2 into different categories. The aim of this study was to investigate the possibility of vertical transmission in asymptomatic SARS-CoV-2-positive women.
Methods: Pregnant women attending for delivery at a perinatology center in Mexico City, Mexico, who had a SARS-CoV-2-positive nasopharyngeal swab 24-48 h before delivery, were asymptomatic at the time of the test and had an obstetric indication for Cesarean section were eligible for inclusion in this study. Amniotic fluid was collected during Cesarean delivery, and neonatal oral and rectal swabs were collected at birth and at 24 h after birth. SARS-CoV-2 detection was carried out using real-time reverse-transcription polymerase chain reaction in all samples. Relevant medical information was retrieved from clinical records. The WHO criteria for classifying the timing of mother-to-child transmission of SARS-CoV-2 were applied to the study population.
Results: Forty-two SARS-CoV-2-positive asymptomatic pregnant women fulfilled the inclusion criteria. Twenty-five (59%) women developed mild disease after discharge. Neonatal death occurred in three (7%) cases, of which one had a positive SARS-CoV-2 test at birth and none had coronavirus disease 2019-related symptoms. There were five (12%) cases with strong evidence of intrauterine transmission of SARS-CoV-2, according to the WHO criteria, as amniotic fluid samples and neonatal samples at birth and at 24 h after birth were positive for SARS-CoV-2. Our results also showed that 40-60% of infected neonates would have been undetected if only one swab (oral or rectal) was tested.
Conclusion: This study contributes evidence to reinforce the potential for vertical transmission of SARS-CoV-2 even in asymptomatic women and highlights the importance of testing more than one neonatal sample in order to increase the detection rate of SARS-CoV-2 in affected cases. © 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
(© 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.)
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معلومات مُعتمدة: 2020-1-32 Instituto Nacional de Perinatología
فهرسة مساهمة: Investigator: LD Gonzalez-García; CD Mora-Vargas; P Mateu-Rogell; M Rodriguez-Bosch; I Coronado-Zarco; S Acevedo-Gallegos; M Aguinaga-Ríos; VH Ramirez-Santes; MA Ortiz-Ramirez; M Valdes-Flores; M Cortes-Bonilla
Keywords: COVID-19; SARS-CoV-2; newborn testing; pregnancy; vertical transmission
تواريخ الأحداث: Date Created: 20210928 Date Completed: 20211209 Latest Revision: 20211214
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8661610
DOI: 10.1002/uog.24787
PMID: 34580942
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-0705
DOI:10.1002/uog.24787