دورية أكاديمية
[Systematic review and Meta-analysis of efficacy and safety of Toutongning Capsules in treatment of tension-type headache].
| العنوان: | [Systematic review and Meta-analysis of efficacy and safety of Toutongning Capsules in treatment of tension-type headache]. |
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| المؤلفون: | Fan XM; Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China Center for Evidence-based Chinese Medicine,Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China., Wei JJ; Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China Graduate School,Beijing University of Chinese Medicine Beijing 100029,China., Zhang YL; Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China., Liao X; Center for Evidence-based Chinese Medicine,Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China., Liang X; Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China., Fu GJ; Graduate School,Beijing University of Chinese Medicine Beijing 100029,China., Gong X; Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China., Chen WJ; Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China., Piao JZ; Graduate School,Beijing University of Chinese Medicine Beijing 100029,China., Yan Y; Graduate School,Beijing University of Chinese Medicine Beijing 100029,China., Guo CL; Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China., Yan YM; Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712000,China., Yang J; Chongqing Traditional Chinese Medicine Hospital Chongqing 400011,China. |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2021 Sep; Vol. 46 (18), pp. 4623-4632. |
| نوع المنشور: | Journal Article; Meta-Analysis; Systematic Review |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Drugs, Chinese Herbal* , Tension-Type Headache*/drug therapy, Capsules ; Databases, Factual ; Humans ; Treatment Outcome |
| مستخلص: | This study aims to systematically evaluate the clinical efficacy and safety of Toutongning Capsules in the treatment of tension-type headache(TTH), so as to provide a corresponding basis for clinical treatment. Eight commonly used medical research databases and two clinical trial registration systems were retrieved with the time interval from the establishment of the database or system to November 2020. The randomized controlled trials of Toutongning Capsules in the treatment of TTH were screened out according to the pre-set criteria. The quality of the included papers was evaluated by the bias risk assessment tool in Cochrane Reviewers Handbook 6.1 and the data were statistically analyzed by RevMan v5.4 provided by Cochrane collaboration. A total of 13 studies were included and the quality of methodology was generally low. Meta-analysis showed that Toutongning Capsules assisted with western medicine therapy can effectively reduce the pain intensity(MD_(VAS)=-1.94,95%CI[-2.50,-1.38],P<0.000 01;MD_(NRS)=-0.83,95%CI[-0.86,-0.80],P<0.000 01), headache duration(SMD=-0.98,95%CI[-1.17,-0.79],P<0.000 01), headache frequency(MD=-1.01,95%CI[-1.16,-0.85],P<0.000 01), headache index(MD=-11.13,95%CI[-12.10,-10.16],P<0.000 01), anxiety and depression scale score(MD_(HAMA)=-4.02,95%CI[-6.58,-1.46],P=0.002;MD_(HAMD)=-2.67,95%CI[-4.04,-1.29],P=0.000 1), while Toutongning Capsules as monotherapy only reduced the headache score(MD=-2.24,95%CI[-2.97,-1.51],P<0.000 01). The available clinical studies demonstrate that Toutongning Capsules combined with western medicine in the treatment of TTH can improve the related outcome indicators, but the clinical safety and efficacy of Toutongning Capsules alone remain unclear. Due to the small number and low quality of the included studies, large-sample, multi-center, high-quality and strictly designed randomized controlled trials are still needed to verify the clinical efficacy in the future. |
| فهرسة مساهمة: | Keywords: Meta-analysis; Toutongning Capsules; efficacy; safety; systematic review; tension-type headache |
| المشرفين على المادة: | 0 (Capsules) 0 (Drugs, Chinese Herbal) |
| تواريخ الأحداث: | Date Created: 20210928 Date Completed: 20210929 Latest Revision: 20210929 |
| رمز التحديث: | 20240628 |
| DOI: | 10.19540/j.cnki.cjcmm.20210520.501 |
| PMID: | 34581070 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5302 |
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| DOI: | 10.19540/j.cnki.cjcmm.20210520.501 |