دورية أكاديمية
أعرض في EDS

Characterization of Outcomes by Surgical Management of Lung Neuroendocrine Tumors Associated With Cushing Syndrome.

التفاصيل البيبلوغرافية
العنوان: Characterization of Outcomes by Surgical Management of Lung Neuroendocrine Tumors Associated With Cushing Syndrome.
المؤلفون: Seastedt KP; Department of Surgery UHS F. Edward Hébert School of Medicine, Bethesda, Maryland.; Now with Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Alyateem GA; Thoracic Surgery Branch, National Cancer Institute, Bethesda, Maryland., Pittala K; Thoracic Surgery Branch, National Cancer Institute, Bethesda, Maryland., Steinberg SM; Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Schrump DS; Thoracic Surgery Branch, National Cancer Institute, Bethesda, Maryland., Nieman LK; Diabetes, Endocrine and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland., Hoang CD; Thoracic Surgery Branch, National Cancer Institute, Bethesda, Maryland.
المصدر: JAMA network open [JAMA Netw Open] 2021 Sep 01; Vol. 4 (9), pp. e2124739. Date of Electronic Publication: 2021 Sep 01.
نوع المنشور: Journal Article; Observational Study; Research Support, N.I.H., Intramural
اللغة: English
بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Chicago, IL : American Medical Association, [2018]-
مواضيع طبية MeSH: Cushing Syndrome/*mortality , Lung/*surgery , Lung Neoplasms/*surgery , Neuroendocrine Tumors/*surgery , Pneumonectomy/*mortality, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cushing Syndrome/etiology ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/complications ; Lung Neoplasms/mortality ; Lymph Node Excision/mortality ; Male ; Mastectomy, Segmental/methods ; Mastectomy, Segmental/mortality ; Middle Aged ; Neoplasm Staging ; Neuroendocrine Tumors/complications ; Neuroendocrine Tumors/mortality ; Pneumonectomy/methods ; Prognosis ; Retrospective Studies ; Thoracic Surgery, Video-Assisted/mortality ; Treatment Outcome ; Young Adult
مستخلص: Importance: Ectopic adrenocorticotropic hormone secretion from lung tumors causing Cushing syndrome are associated with high rates of morbidity. Optimal management remains obscure because knowledge is based on rare reports with few patients.
Objective: To characterize the outcomes of lung neuroendocrine tumors associated with Cushing syndrome.
Design, Setting, and Participants: An observational case series review from 1982 to 2020 was conducted in a single institution referral center. Kaplan-Meier analysis estimated disease-free survival (DFS). Participants underwent curative-intent surgery for a lung neuroendocrine tumor causing Cushing syndrome.
Exposures: Lobectomy or pneumonectomy vs sublobar resection.
Main Outcomes and Measures: Disease-free survival, disease persistence/recurrence.
Results: Of the 68 patients, the median age was 41 years (range, 17-80 years), 42.6% (29 of 68) were male, 81.8% (54 of 66) were White, with a mean follow-up after surgery was 16 months (range, 0.1-341 months). Lobectomy was the most common procedure (48 of 68 [70.6%]), followed by wedge resection (16 of 68 [23.5%]) and segmentectomy (3 of 68 [4.4%]). Video-assisted thoracoscopic surgery was performed in 19 of 68 (27.9%) of patients. Surgical morbidity was 19.1% (13 of 68), and perioperative mortality was 1.5% (1 of 68). Lymph node positivity was 37% (22 of 59) when evaluable. The overall incidence of persistence/recurrence was 16.2% (11 of 68) with a median time to recurrence of 55 months (range, 18-152 months). The median DFS was reached in 12.7 years (0.1-334 months). There were no statistical differences in DFS based on tumor size, stage (8th edition TNM), whether full systematic lymphadenectomy was performed or not, nodal status, or surgical approach.
Conclusions and Relevance: In this case series study, neuroendocrine pulmonary tumors associated with Cushing syndrome had increased nodal metastasis, higher recurrence, and lower DFS than quiescent bronchopulmonary carcinoid tumors, but many patients experienced favorable outcomes. This observation is underscored by the discordance of TNM-stage classifications vs prognosis. Observing no difference in surgical techniques, the implication may be that a lung-sparing approach could suffice. These results may reflect the intrinsic importance of the hormone physiology instead of the carcinoid biologic factors.
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تواريخ الأحداث: Date Created: 20210929 Date Completed: 20220112 Latest Revision: 20220112
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8482056
DOI: 10.1001/jamanetworkopen.2021.24739
PMID: 34586369
قاعدة البيانات: MEDLINE
الوصف
تدمد:2574-3805
DOI:10.1001/jamanetworkopen.2021.24739