دورية أكاديمية
Towards magnetic-field-modulated radiotherapy (MagMRT) with an MR-LINAC-a Monte Carlo study.
| العنوان: | Towards magnetic-field-modulated radiotherapy (MagMRT) with an MR-LINAC-a Monte Carlo study. |
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| المؤلفون: | Chu VWS; Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, People's Republic of China.; Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China., Kan MWK; Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, People's Republic of China.; Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China., Wong KCW; Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, People's Republic of China.; Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China., Lee LKY; CUHK Medical Centre, Hong Kong SAR, People's Republic of China., Chan ATC; Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, People's Republic of China.; Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.; State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. |
| المصدر: | Physics in medicine and biology [Phys Med Biol] 2021 Oct 14; Vol. 66 (20). Date of Electronic Publication: 2021 Oct 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol : IOP Publishing |
| مواضيع طبية MeSH: | Particle Accelerators* , Radiation Oncology*, Magnetic Fields ; Monte Carlo Method ; Phantoms, Imaging ; Radiotherapy Dosage |
| مستخلص: | Objective. The feasibility of magnetic-field-modulated radiotherapy (MagMRT) with an MR-LINAC was investigated by studying the effects of dose enhancement and reduction using a transverse magnetic field with a longitudinal gradient applied along a photon radiation beam. Approach. Geant4 simulation toolkit was used to perform Monte Carlo simulations on a water phantom with the energy spectrum of a 7 MV flattening-filter-free photon beam from an Elekta Unity system as the source of radiation. Linear magnetic field gradients with magnitudes ranged from 1 to 6 T cm -1 and spatial extents of 1-3 cm were used to study the dependence of dose modulation on these two parameters. The effects of radiation field size and the ability of dose modulation through optimizing the waveform of magnetic field variation were also explored. Main results. Our results show that dose enhancement and reduction can be achieved by applying a transverse magnetic field with a longitudinal field gradient along a photon beam. The steeper the gradient, the more prominent is the effect. A dose enhancement of 33% and a dose reduction of 22% are found for a magnetic gradient of 6 T cm -1 and -6 T cm -1 respectively. The spatial extent of the dose modulation effect which is greater than 3% is found to be around 1-2 cm. Both the dose enhancement and reduction effects are independent of the radiation field sizes, but they exhibit different behaviors with the spatial extents of the gradient. Multiple locations of dose enhancement and reduction can be produced by modulating the waveform of the magnetic field variation along the radiation beam, demonstrating a vast degree of freedom in the modulation aspect of MagMRT. Significance. MagMRT is a conceptually feasible and promising new radiotherapy modulation technique along the direction of the radiation beam. (© 2021 Institute of Physics and Engineering in Medicine.) |
| فهرسة مساهمة: | Keywords: MR-LINAC; Monte Carlo; dose modulation; magnetic field; magnetic field modulated radiotherapy |
| تواريخ الأحداث: | Date Created: 20210929 Date Completed: 20220415 Latest Revision: 20220415 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1088/1361-6560/ac2b83 |
| PMID: | 34587609 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1361-6560 |
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| DOI: | 10.1088/1361-6560/ac2b83 |