دورية أكاديمية
أعرض في EDS

Local injury and systemic infection in infants alter later nociception and pain affect during early life and adulthood.

التفاصيل البيبلوغرافية
العنوان: Local injury and systemic infection in infants alter later nociception and pain affect during early life and adulthood.
المؤلفون: Gomes CI; Department of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Barr GA; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA.; Department of Psychology, University of Pennsylvania, 425 S. University Avenue, Stephen A. Levin Building, Philadelphia, PA, USA.
المصدر: Brain, behavior, & immunity - health [Brain Behav Immun Health] 2020 Nov 10; Vol. 9, pp. 100175. Date of Electronic Publication: 2020 Nov 10 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101759062 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3546 (Electronic) Linking ISSN: 26663546 NLM ISO Abbreviation: Brain Behav Immun Health Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier Inc., [2020]-
مستخلص: Newborns in intensive care are regularly exposed to minor painful procedures at developmental time points when noxious stimulation would be normally absent. Pain from these interventions is inconsistently treated and often exists concurrently with systemic infection, a common comorbidity of prematurity. Our understanding of the independent and combined effects of early painful experiences and infection on pain response is incomplete. The main goals of this research therefore were to understand how pain and infection experienced early in life influence future nociceptive and affective responses to painful stimuli. Rat pups were infected with E-coli on postnatal day 2 (PN2) and had left hind paw injury with carrageenan on PN3. Standard thermal tests for acute pain, formalin tests for inflammatory pain, and conditioned place aversion testing were performed at different ages to assess the nociceptive and affective components of the pain response. Early E-coli infection and early inflammatory injury with carrageenan both independently increased pain scores following hind paw reinjury with formalin on PN8, with effects persisting into adulthood in the carrageenan exposed group. When experienced concurrently, early E-coli infection and carrageenan exposure also increased conditioned aversion to pain in adults. Effect of sex was significant only in formalin testing, with males showing higher pain scores in infancy and females showing higher pain scores as adults. These findings demonstrate that infection experienced early in life can alter both the nociceptive and affective components of the pain response and that there is a cumulative effect of local and systemic pro-inflammatory processes on the aversive component of pain.
Competing Interests: The authors have no conflicts of interest to disclose.
(© 2020 The Authors.)
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فهرسة مساهمة: Keywords: Carrageenan; Conditioned place aversion; E-Coli; Formalin test; Ontogeny; Sensitive period
تواريخ الأحداث: Date Created: 20210930 Latest Revision: 20211001
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8474633
DOI: 10.1016/j.bbih.2020.100175
PMID: 34589906
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-3546
DOI:10.1016/j.bbih.2020.100175