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Behavioral, neuroplasticity and metabolic effects of 7,8-dihydroxy-4-methylcoumarin associated with physical activity in mice.

التفاصيل البيبلوغرافية
العنوان: Behavioral, neuroplasticity and metabolic effects of 7,8-dihydroxy-4-methylcoumarin associated with physical activity in mice.
المؤلفون: Lopes PKF; Department of Health Sciences, Federal University of Lavras, Lavras, MG, 37200-900, Brazil., Engel DF; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil. daiane.engel01@gmail.com.; School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG, 35400-000, Brazil. daiane.engel01@gmail.com., Bertolini NO; Department of Health Sciences, Federal University of Lavras, Lavras, MG, 37200-900, Brazil., de Azevedo Martins MS; Department of Health Sciences, Federal University of Lavras, Lavras, MG, 37200-900, Brazil., Pereira CA; Department of Health Sciences, Federal University of Lavras, Lavras, MG, 37200-900, Brazil., Velloso LA; Laboratory of Cell Signaling and Obesity and Comorbidities Research Center, University of Campinas, Campinas, SP, 13084-970, Brazil., Thomasi SS; Department of Chemistry, Federal University of Lavras, Lavras, MG, 37200-900, Brazil., de Moura RF; Department of Health Sciences, Federal University of Lavras, Lavras, MG, 37200-900, Brazil.
المصدر: Metabolic brain disease [Metab Brain Dis] 2021 Dec; Vol. 36 (8), pp. 2425-2436. Date of Electronic Publication: 2021 Oct 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Amsterdam : Springer
Original Publication: New York : Plenum, c1986-
مواضيع طبية MeSH: Coumarins*/pharmacology , Neuronal Plasticity*, Animals ; Hippocampus/metabolism ; Mice ; Mice, Inbred C57BL
مستخلص: The search for strategies to develop resilience against metabolic and neuropsychiatric disorders has motivated the clinical and experimental assessment of early life interventions such as lifestyle-based and use of unconventional pharmacological compounds. In this study, we assessed the effects of voluntary physical activity and 7,8-Dihydroxy-4-methylcoumarin (DHMC), independently or in combination, over mice physiological and behavioral parameters, adult hippocampal and hypothalamic neurogenesis, and neurotrophic factors expression in the hypothalamus. C57Bl/6J mice were submitted to a 29-day treatment with DHMC and allowed free access to a running wheel. We found that DHMC treatment alone reduced fasting blood glucose levels. Moreover, physical activity showed an anxiolytic effect in the elevated plus maze task and DHMC produced additional anxiolytic behavior, evidenced by reduced activity during the light cycle in the physical activity group. Although we did not find any differences in hypothalamic or hippocampal adult neurogenesis, DHMC increased gene expression levels of VEGF, which was correlated to the reduced fasting glucose levels. In conclusion, our data emphasize the potential of physical activity in reducing development of neuropsychiatric conditions, such as anxiety, and highlights DHMC as an attractive compound to be investigated in future studies addressing neuropsychiatric disorders associated with metabolic conditions.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Anxiolytic; Coumarin; DHMC; Fasting glucose; Physical activity; VEGF
المشرفين على المادة: 0 (7,8-dihydroxy-4-methylcoumarin)
0 (Coumarins)
تواريخ الأحداث: Date Created: 20211002 Date Completed: 20220407 Latest Revision: 20220510
رمز التحديث: 20231215
DOI: 10.1007/s11011-021-00849-7
PMID: 34599738
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-7365
DOI:10.1007/s11011-021-00849-7