دورية أكاديمية
Protective role of salicylic acid in gentamicin induced nephrotoxicity.
| العنوان: | Protective role of salicylic acid in gentamicin induced nephrotoxicity. |
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| المؤلفون: | Fatimah SN; Clinical Biochemistry and Hematology Research Lab, Department of Biochemistry, Federal Urdu University, Karachi, Pakistan., Usman SM; Clinical Biochemistry and Hematology Research Lab, Department of Biochemistry, Federal Urdu University, Karachi, Pakistan. |
| المصدر: | Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2021 May; Vol. 34 (3), pp. 869-874. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Karachi : Faculty of Pharmacy, University of Karachi, [1988- |
| مواضيع طبية MeSH: | Acute Kidney Injury/*chemically induced , Anti-Bacterial Agents/*toxicity , Antioxidants/*pharmacology , Gentamicins/*toxicity , Kidney/*drug effects , Salicylic Acid/*pharmacology, Acute Kidney Injury/metabolism ; Animals ; Body Weight/drug effects ; Catalase/drug effects ; Catalase/metabolism ; Creatinine/blood ; Kidney/metabolism ; Malondialdehyde/metabolism ; Rabbits ; Superoxide Dismutase/drug effects ; Superoxide Dismutase/metabolism ; Urea/blood ; Uric Acid/blood |
| مستخلص: | Salicylic acid, a phenolic compound, found in plants, possesses free radical scavenging and iron chelation properties. The present study is designed to study the antioxidant effect of salicylic acid in gentamicin induced nephrotoxicity in rabbits. For this purpose twenty four male albino rabbits were divided into 4 groups (n=6); control group, healthy untreated rabbits, gentamicin group, received only gentamicin (80mg/kg), gentamicin + salicylic acid group, received gentamicin (80mg/kg) + salicylic acid (80mg/kg) and salicylic acid group, received only salicylic acid (80mg/kg) via intra peritoneal route for 21 consecutive days. Biochemical evaluation was carried out by assessment of body weights and by estimating renal function tests (plasma urea, plasma creatinine and plasma uric acid), tissue antioxidant enzymes (catalase, SOD) and MDA level. Gentamicin induction resulted in decreased body weights, increased plasma urea, plasma creatinine, plasma uric acid, tissue MDA level and decreased tissue SOD and tissue catalase activity in gentamicin treated group which was restored by supplementation with salicylic acid in gentamicin + salicylic acid group. Our data suggests that supplementation of salicylic acid can be useful in reducing gentamicin induced nephrotoxicity in rabbits. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Antioxidants) 0 (Gentamicins) 268B43MJ25 (Uric Acid) 4Y8F71G49Q (Malondialdehyde) 8W8T17847W (Urea) AYI8EX34EU (Creatinine) EC 1.11.1.6 (Catalase) EC 1.15.1.1 (Superoxide Dismutase) O414PZ4LPZ (Salicylic Acid) |
| تواريخ الأحداث: | Date Created: 20211004 Date Completed: 20220131 Latest Revision: 20220131 |
| رمز التحديث: | 20221213 |
| PMID: | 34602408 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1011-601X |
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