دورية أكاديمية
Impact of donor telomere length on survival in patients undergoing matched sibling donor transplantation for aplastic anaemia.
| العنوان: | Impact of donor telomere length on survival in patients undergoing matched sibling donor transplantation for aplastic anaemia. |
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| المؤلفون: | Barade A; Department of Haematology, Christian Medical College Vellore, Vellore, India., Aboobacker F; Department of Haematology, Christian Medical College Vellore, Vellore, India., Korula A; Department of Haematology, Christian Medical College Vellore, Vellore, India., Lakshmi K; Department of Haematology, Christian Medical College Vellore, Vellore, India., Devasia A; Department of Haematology, Christian Medical College Vellore, Vellore, India., Abraham A; Department of Haematology, Christian Medical College Vellore, Vellore, India., Mathews V; Department of Haematology, Christian Medical College Vellore, Vellore, India., Edison E; Department of Haematology, Christian Medical College Vellore, Vellore, India., George B; Department of Haematology, Christian Medical College Vellore, Vellore, India. |
| المصدر: | British journal of haematology [Br J Haematol] 2022 Feb; Vol. 196 (3), pp. 724-734. Date of Electronic Publication: 2021 Oct 03. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Hematopoietic Stem Cell Transplantation*/methods , Hematopoietic Stem Cell Transplantation*/mortality , Siblings* , Telomere Homeostasis* , Tissue Donors*, Anemia, Aplastic/*mortality , Anemia, Aplastic/*therapy , Telomere/*genetics, Adolescent ; Adult ; Age Factors ; Child ; Child, Preschool ; Female ; Graft Rejection ; Graft Survival ; Humans ; Male ; Middle Aged ; Prognosis ; Transplantation Conditioning/methods ; Treatment Outcome ; Young Adult |
| مستخلص: | Although telomere shortening is seen frequently in patients with aplastic anaemia (AA), there are no data on its association in matched sibling donor (MSD) transplants. We evaluated the effect of pre-transplant telomere length of patients and donors, measured by quantitative real-time polymerase chain reaction in 163 recipients undergoing MSD transplants. The median age of patients and donors was 24 and 26 years, respectively. Fludarabine and cyclophosphamide was the main conditioning regimen used and all received peripheral blood stem cell grafts. Engraftment occurred in 89% with graft failure (primary and secondary) in 6%. Acute and chronic graft-versus-host disease (GVHD) occurred in 28% and 24%, respectively. At a median follow-up of 37 months, 117 patients (72%) were alive. All patients and donors were divided into short and long telomere length based on their median and quartile values. Patient telomere length was not associated with severity of AA, neutrophil recovery, graft failure, acute GVHD or chronic GVHD. Longer donor telomere length was associated with better overall survival [hazard ratio (HR) = 0·2, P = 0·006] but did not influence neutrophil recovery, graft failure, acute or chronic GVHD. The five-year overall survival was significantly better (94·9 ± 3·5% vs 65·4 ± 4·3%, P = 0·002) for donors with long (highest quartile, DTL-HQ) versus short (lower three quartiles, DTL-LQ) telomeres, respectively. On multivariate analysis, longer donor telomere length, recipient age and acute GVHD continued to remain significant. This is the first study demonstrating an association of donor telomere length on overall survival following MSD transplant for AA but it needs to be confirmed in larger studies. (© 2021 British Society for Haematology and John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: aplastic anaemia; haematopoietic stem cell transplantation; matched sibling donor; overall survival; telomere length |
| تواريخ الأحداث: | Date Created: 20211004 Date Completed: 20220214 Latest Revision: 20220214 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/bjh.17880 |
| PMID: | 34605011 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2141 |
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| DOI: | 10.1111/bjh.17880 |