دورية أكاديمية
The Intestinal Commensal, Bacteroides fragilis, Modulates Host Responses to Viral Infection and Therapy: Lessons for Exploration during Mycobacterium tuberculosis Infection.
| العنوان: | The Intestinal Commensal, Bacteroides fragilis, Modulates Host Responses to Viral Infection and Therapy: Lessons for Exploration during Mycobacterium tuberculosis Infection. |
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| المؤلفون: | Eribo OA; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., du Plessis N; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Chegou NN; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. |
| المصدر: | Infection and immunity [Infect Immun] 2022 Jan 25; Vol. 90 (1), pp. e0032121. Date of Electronic Publication: 2021 Oct 04. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : American Society For Microbiology Original Publication: [Bethesda, Md.] American Society for Microbiology. |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome* , Host-Pathogen Interactions*/immunology , Microbial Interactions*, Bacteroides fragilis/*physiology , Virus Diseases/*etiology , Virus Diseases/*therapy, Antibiosis ; Cytokines/metabolism ; Disease Management ; Disease Resistance/immunology ; Disease Susceptibility ; Humans ; Immunomodulation ; Inflammation Mediators/metabolism ; Interferons/metabolism ; Organ Specificity ; Polysaccharides, Bacterial/immunology ; Probiotics ; Symbiosis ; Tuberculosis/etiology ; Virus Diseases/metabolism |
| مستخلص: | The gut microbiota has emerged as a critical player in host health. Bacteroides fragilis is a prominent member of the gut microbiota within the phyla Bacteroidetes. This commensal bacterium produces unique capsular polysaccharides processed by antigen-presenting cells and activates CD4 + T cells to secrete inflammatory cytokines. Indeed, due to their immunomodulatory functions, B. fragilis and its capsular polysaccharide-A (PSA) are arguably the most explored single commensal microbiota/symbiotic factor. B. fragilis / PSA has been shown to protect against colitis, encephalomyelitis, colorectal cancer, pulmonary inflammation, and asthma. Here, we review recent data on the immunomodulatory role of B. fragilis/PSA during viral infections and therapy, B. fragilis PSA's dual ability to mediate pro-and anti-inflammatory processes, and the potential for exploring this unique characteristic during intracellular bacterial infections such as with Mycobacterium tuberculosis. We also discuss the protective roles of single commensal-derived probiotic species, including B. fragilis in lung inflammation and respiratory infections that may provide essential cues for possible exploration of microbiota based/augmented therapies in tuberculosis (TB). Available data on the relationship between B. fragilis / PSA, the immune system, and disease suggest clinical relevance for developing B. fragilis into a next-generation probiotic or, possibly, the engineering of PSA into a potent carbohydrate-based vaccine. |
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| معلومات مُعتمدة: | National Research Foundation (NRF) |
| فهرسة مساهمة: | Keywords: Bacteroides fragilis; Gut microbiota; Mycobacterium tuberculosis; polysaccharide A; probiotics; tuberculosis; viral infection |
| المشرفين على المادة: | 0 (Cytokines) 0 (Inflammation Mediators) 0 (Polysaccharides, Bacterial) 9008-11-1 (Interferons) |
| تواريخ الأحداث: | Date Created: 20211004 Date Completed: 20220221 Latest Revision: 20220726 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8788684 |
| DOI: | 10.1128/IAI.00321-21 |
| PMID: | 34606367 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-5522 |
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| DOI: | 10.1128/IAI.00321-21 |