Visual inspection with acetic acid screening for cervical cancer among women receiving anti-retroviral therapy for human immunodeficiency virus infection in northern Tanzania.

التفاصيل البيبلوغرافية
العنوان:	Visual inspection with acetic acid screening for cervical cancer among women receiving anti-retroviral therapy for human immunodeficiency virus infection in northern Tanzania.
المؤلفون:	Chinn JO; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Runge AS; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Dinicu AI; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Chang J; Department of Medicine, School of Medicine, University of California Irvine, Orange, California, USA., Maher JA; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Crawford EW; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Naaseh A; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Cooper EC; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Zezoff DC; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., White KM; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Lucas AN; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Bera KR; Department of Medical Education, University of California, Irvine College of Medicine, Irvine, California, USA., Bernstein M; Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA., Hari A; Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA., Ziogas A; Department of Medicine, School of Medicine, University of California Irvine, Orange, California, USA., Tewari SE; Bowdoin College, Brunswick, Maine, USA., Pearre DC; Department of Gynecology Oncology, University of California Irvine, Orange, California, USA., Tewari KS; Department of Gynecology Oncology, University of California Irvine, Orange, California, USA.
المصدر:	The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2021 Dec; Vol. 47 (12), pp. 4365-4370. Date of Electronic Publication: 2021 Oct 06.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley on behalf of the Japan Society of Obstetrics and Gynecology] Country of Publication: Australia NLM ID: 9612761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1447-0756 (Electronic) Linking ISSN: 13418076 NLM ISO Abbreviation: J Obstet Gynaecol Res Subsets: MEDLINE
أسماء مطبوعة:	Publication: [Melbourne, Vic. : Wiley on behalf of the Japan Society of Obstetrics and Gynecology] Original Publication: Tokyo : University of Tokyo Press, c1996-
مواضيع طبية MeSH:	HIV Infections/complications , HIV Infections/drug therapy , Papillomavirus Infections* , Uterine Cervical Neoplasms*/diagnosis, Acetic Acid ; Early Detection of Cancer ; Female ; Humans ; Mass Screening ; Tanzania/epidemiology
مستخلص:	Aim: To evaluate visual inspection with acetic acid (VIA) screening for cervical cancer among human immunodeficiency virus (HIV)-positive patients in an East African community. Methods: During a July 2018 cervical cancer screen-and-treat in Mwanza, Tanzania, participants were offered free cervical VIA screening, cryotherapy when indicated, and HIV testing. Acetowhite lesions and/or abnormal vascularity were designated VIA positive in accordance with current guidelines. The association between VIA results and HIV status was compared using Chi-square and Fisher exact tests. Results: Eight hundred and twenty-four of 921 consented participants underwent VIA screening and 25.0% (n = 206) were VIA positive. VIA-positive nonpregnant women (n = 147) received cryotherapy and 15 (1.8%) with cancerous-appearing lesions were referred to Bugando Hospital. Sixty-six women were HIV-positive and included 25 diagnosed with HIV at the cervical cancer VIA screening and 41 with a prior diagnosis of HIV who were receiving antiretroviral therapy (ART) at the time of cervical cancer VIA screening. Sixty-four of these 66 patients, were screened with VIA. HIV infection was not associated with VIA findings. Abnormal VIA positive screening was observed in 20.3% (n = 13) of HIV-positive patients and in 24.4% (n = 145) of HIV-negative patients (p = 0.508). A nonsignificant trend of higher VIA positive screens among newly diagnosed HIV patients of 26.1% (n = 6) versus patients with preexisting HIV on ART of 17.1% (n = 7) was observed (p = 0.580). Conclusion: The unexpected lack of correlation between HIV infection and VIA positivity in a community with access to ART warrants additional research regarding the previously described role of ART in attenuating HPV-mediated neoplasia. (© 2021 Japan Society of Obstetrics and Gynecology.)
References:	Menon S, Luchters S, Rossi R, et al. Human papilloma virus correlates of high grade cervical dysplasia in HIV-infected women in Mombasa, Kenya: a cross-sectional analysis. Virol J. 2018;15:54. Dreyer G. Clinical implications of the interaction between HPV and HIV infections. Best Pract Res Clin Obstet Gynaecol. 2018;47:95-106. Kileo N Tanzania rolls out vaccination against cervical cancer. World Health Organ. 2018;1-9. World Health Organization. WHO Antiretroviral Therapy Coverage Estimates by Country, [WHO website]. 2019. https://apps.who.int/gho/data/node.main.626. Accessed July 19, 2020. Biggar RJ, Chaturvedi AK, Goedert JJ, Engels EA. AIDS-related cancer and severity of immunosuppression in persons with AIDS. J Natl Cancer Inst. 2007;99(12):962-72. Minkoff H, Zhong Y, Burk RD, Palefsky JM, Xue X, Watts DH, et al. Influence of adherent and effective antiretroviral therapy use on human papillomavirus infection and squamous intraepithelial lesions in human immunodeficiency virus-positive women. J Infect Dis. 2010;201(5):681-90. Shastri SS, Mittra I, Mishra GA, et al. Effect of VIA screening by primary health workers: randomized controlled study in Mumbai, India. J Natl Cancer Inst. 2014;106(3):dju009. Sauvaget C, Fayette JM, Muwonge R, Wesley R, Sankaranarayanan R. Accuracy of visual inspection with acetic acid for cervical cancer screening. Int J Gynaecol Obstet. 2011;113(1):14-24. Phongsavan K, Phengsavanh A, Wahlström R, Marions L. Safety, feasibility, and acceptability of visual inspection with acetic acid and immediate treatment with cryotherapy in rural Laos. Int J Gynaecol Obstet. 2011;114(3):268-72. Adefuye PO, Dada OA, Adefuye BO, Shorunmu TO, Akinyemi BO, Idowu-Ajiboye BO. Feasibility, acceptability, and effectiveness of visual inspection of the cervix with acetic acid and cryotherapy for dysplasia in Nigeria. Int J Gynaecol Obstet. 2015;129(1):62-6. World Health Organization. Cervical Cancer Screening and Management of Cervical Pre-Cancers: Training of Health Staff in VIA. HPV Detection Test and Cryotherapy Trainees' Handbook. Geneva, Switzerland: WHO; 2017 https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwjX3fSzjNrqAhUTPH0KHbMSAwkQFjAAegQIBBAB&url=https%3A%2F%2Fapps.who.int%2Firis%2Frest%2Fbitstreams%2F1087895%2Fretrieve&usg=AOvVaw0nUujx3Pb5z7JRkxp2WlYB. Accessed July 19, 2020. Maher J, Lucas A, Zezoff D, Crawford E, Chang J, Ziogas A, et al. Towards eliminating cervical cancer in East Africa: feasibility of visual inspection with acetic acid (VIA) screening and immediate cryotherapy in rural and urban Tanzania (poster presentation). Gynecol Oncol. 2019;154:108. Blitz S, Baxter J, Raboud J, Walmsley S, Rachlis A, Smaill F, et al. Evaluation of HIV and highly active antiretroviral therapy on the natural history of human papillomavirus infection and cervical Cytopathologic findings in HIV-positive and high-risk HIV-negative women. J Infect Dis. 2013;208:454-62. Kang M, Cu-Ulvin S. Association of HIV viral load and CD4 cell count with human papillomavirus detection and clearance in HIV-infected women initiating highly active antiretroviral therapy. HIV Med. 2012;13:372-8. Chinn J, Tewari K. Multimodality screening and prevention of cervical cancer in sub-Saharan Africa: a collaborative model. Curr Opin Obstet Gynecol. 2020;32:28-35. Blumenthal PD, Lauterbach M, Sellors JW, Sankaranarayanan R. Training for cervical cancer prevention programs in low-resource settings: focus on visual inspection with acetic acid and cryotherapy. Int J Gynaecol Obstet. 2005;89:S30-7. Runge AS, Bernstein ME, Lucas AN, Tewari K. Cervical cancer in Tanzania: a systematic review of current challenges in six domains. Gynecol Oncol Rep. 2019;29:40-7.
معلومات مُعتمدة:	by The UC Irvine Institute for Clinical and Translational Science
فهرسة مساهمة:	Keywords: HIV; HPV; VIA; antiretroviral therapy; cervical cancer; global health
المشرفين على المادة:	Q40Q9N063P (Acetic Acid)
تواريخ الأحداث:	Date Created: 20211006 Date Completed: 20211203 Latest Revision: 20211214
رمز التحديث:	20231215
DOI:	10.1111/jog.15011
PMID:	34614540
قاعدة البيانات:	MEDLINE

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تدمد:	1447-0756
DOI:	10.1111/jog.15011