دورية أكاديمية
أعرض في EDS

CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn's disease.

التفاصيل البيبلوغرافية
العنوان: CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn's disease.
المؤلفون: Krabbendam L; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Department of Pulmonary Medicine, Erasmus MC, Rotterdam, Netherlands., Heesters BA; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands., Kradolfer CMA; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Haverkate NJE; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Becker MAJ; Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology & Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Buskens CJ; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Amsterdam UMC, University of Amsterdam, Department of Surgery, Amsterdam Gastroenterology & Metabolism (AG&M), Meibergdreef 9, Amsterdam, The Netherlands., Bemelman WA; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Amsterdam UMC, University of Amsterdam, Department of Surgery, Amsterdam Gastroenterology & Metabolism (AG&M), Meibergdreef 9, Amsterdam, The Netherlands., Bernink JH; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584, CT, Utrecht, The Netherlands., Spits H; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. hergen.spits@amsterdamumc.nl.
المصدر: Nature communications [Nat Commun] 2021 Oct 06; Vol. 12 (1), pp. 5841. Date of Electronic Publication: 2021 Oct 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Antigens, Differentiation, T-Lymphocyte/*metabolism , Crohn Disease/*immunology , Crohn Disease/*metabolism , Interleukin-7 Receptor alpha Subunit/*metabolism , Lymphocytes/*metabolism , NK Cell Lectin-Like Receptor Subfamily D/*metabolism , Perforin/*metabolism, Antigens, Differentiation, T-Lymphocyte/genetics ; Cells, Cultured ; Crohn Disease/genetics ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Humans ; Immunity, Innate/genetics ; Immunity, Innate/physiology ; Inflammation/immunology ; Inflammation/metabolism ; Lymphocytes/immunology ; Perforin/genetics ; Real-Time Polymerase Chain Reaction
مستخلص: Phenotypic definition of helper ILC1 and NK cells is problematic due to overlapping markers. Recently we showed the identification of cytotoxic ILC3s characterized by expression of CD94. Here we analyse CD127+ ILCs and NK cells in intestinal lamina propria from healthy donors and Crohn's disease patients and identify two populations of CD127+CD94+ ILCs, designated population A and B, that can be distinguished on the expression of CD117, CD18 and cytotoxic molecules. Population B expresses granulysin, a cytotoxic molecule linked to bacterial lysis and/or chemotaxis of monocytes. Granulysin protein is secreted by population B cells upon stimulation with IL-15. Activation of population B in the presence of TGF-β strongly reduces the expression of cytotoxic effector molecules of population B. Strikingly, samples from individuals that suffer from active Crohn's disease display enhanced frequencies of granulysin-expressing effector CD127+CD94+ ILCs in comparison to controls. Thus this study identifies group 1 ILC populations which accumulate in inflamed intestinal tissue of Crohn's disease patients and may play a role in the pathology of the disease.
(© 2021. The Author(s).)
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المشرفين على المادة: 0 (Antigens, Differentiation, T-Lymphocyte)
0 (GNLY protein, human)
0 (Interleukin-7 Receptor alpha Subunit)
0 (NK Cell Lectin-Like Receptor Subfamily D)
126465-35-8 (Perforin)
تواريخ الأحداث: Date Created: 20211007 Date Completed: 20211019 Latest Revision: 20231107
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8494908
DOI: 10.1038/s41467-021-26187-x
PMID: 34615883
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-021-26187-x