دورية أكاديمية
أعرض في EDS

Mosaic vaccination: How distributing different vaccines across a population could improve epidemic control.

التفاصيل البيبلوغرافية
العنوان: Mosaic vaccination: How distributing different vaccines across a population could improve epidemic control.
المؤلفون: McLeod DV; Centre D'Ecologie Fonctionnelle & Evolutive CNRS Montpellier 34090 France., Wahl LM; Mathematics Western University London ON N6A 5B7 Canada., Mideo N; Department of Ecology and Evolutionary Biology University of Toronto Toronto ON M5S 3B2 Canada.
المصدر: Evolution letters [Evol Lett] 2021 Aug 23; Vol. 5 (5), pp. 458-471. Date of Electronic Publication: 2021 Aug 23 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101715791 Publication Model: eCollection Cited Medium: Internet ISSN: 2056-3744 (Electronic) Linking ISSN: 20563744 NLM ISO Abbreviation: Evol Lett Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2023- : Oxford : Oxford University Press
Original Publication: [London] : Wiley, [2017]-
مستخلص: Although vaccination has been remarkably effective against some pathogens, for others, rapid antigenic evolution results in vaccination conferring only weak and/or short-lived protection. Consequently, considerable effort has been invested in developing more evolutionarily robust vaccines, either by targeting highly conserved components of the pathogen (universal vaccines) or by including multiple immunological targets within a single vaccine (multi-epitope vaccines). An unexplored third possibility is to vaccinate individuals with one of a number of qualitatively different vaccines, creating a "mosaic" of individual immunity in the population. Here we explore whether a mosaic vaccination strategy can deliver superior epidemiological outcomes to "conventional" vaccination, in which all individuals receive the same vaccine. We suppose vaccine doses can be distributed between distinct vaccine "targets" (e.g., different surface proteins against which an immune response can be generated) and/or immunologically distinct variants at these targets (e.g., strains); the pathogen can undergo antigenic evolution at both targets. Using simple mathematical models, here we provide a proof-of-concept that mosaic vaccination often outperforms conventional vaccination, leading to fewer infected individuals, improved vaccine efficacy, and lower individual risks over the course of the epidemic.
(© 2021 The Authors. Evolution Letters published by Wiley Periodicals LLC on behalf of Society for the Study of Evolution (SSE) and European Society for Evolutionary Biology (ESEB).)
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فهرسة مساهمة: Keywords: antigenic evolution; evolutionary epidemiology; mosaic therapy; vaccination
تواريخ الأحداث: Date Created: 20211008 Latest Revision: 20211009
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8484727
DOI: 10.1002/evl3.252
PMID: 34621533
قاعدة البيانات: MEDLINE
الوصف
تدمد:2056-3744
DOI:10.1002/evl3.252