دورية أكاديمية
أعرض في EDS

Metabolic Biomarkers for the Early Detection of Cancer Cachexia.

التفاصيل البيبلوغرافية
العنوان: Metabolic Biomarkers for the Early Detection of Cancer Cachexia.
المؤلفون: O'Connell TM; Department of Otolaryngology - Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, United States.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, United States.; Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, United States.; IUPUI Center for Cachexia Research Innovation and Therapy, Indiana University School of Medicine, Indianapolis, IN, United States., Golzarri-Arroyo L; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Indianapolis, IN, United States., Pin F; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, United States., Barreto R; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, United States., Dickinson SL; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Indianapolis, IN, United States., Couch ME; Department of Otolaryngology - Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, United States.; Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, United States.; IUPUI Center for Cachexia Research Innovation and Therapy, Indiana University School of Medicine, Indianapolis, IN, United States., Bonetto A; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, United States.; Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, United States.; IUPUI Center for Cachexia Research Innovation and Therapy, Indiana University School of Medicine, Indianapolis, IN, United States.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, United States.; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, United States.
المصدر: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Sep 21; Vol. 9, pp. 720096. Date of Electronic Publication: 2021 Sep 21 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2013]-
مستخلص: Background: Cancer cachexia is a severe metabolic disorder characterized by progressive weight loss along with a dramatic loss in skeletal muscle and adipose tissue. Like cancer, cachexia progresses in stages starting with pre-cachexia to cachexia and finally to refractory cachexia. In the refractory stage, patients are no longer responsive to therapy and management of weight loss is no longer possible. It is therefore critical to detect cachexia as early as possible. In this study we applied a metabolomics approach to search for early biomarkers of cachexia. Methods: Multi-platform metabolomics analyses were applied to the murine Colon-26 (C26) model of cachexia. Tumor bearing mice ( n = 5) were sacrificed every other day over the 14-day time course and control mice ( n = 5) were sacrificed every fourth day starting at day 2. Linear regression modeling of the data yielded metabolic trajectories that were compared with the trajectories of body weight and skeletal muscle loss to look for early biomarkers of cachexia. Results: Weight loss in the tumor-bearing mice became significant at day 9 as did the loss of tibialis muscle. The loss of muscle in the gastrocnemius and quadriceps was significant at day 7. Reductions in amino acids were among the earliest metabolic biomarkers of cachexia. The earliest change was in methionine at day 4. Significant alterations in acylcarnitines and lipoproteins were also detected several days prior to weight loss. Conclusion: The results of this study demonstrate that metabolic alterations appear well in advance of observable weight loss. The earliest and most significant alterations were found in amino acids and lipoproteins. Validation of these results in other models of cachexia and in clinical studies will pave the way for a clinical diagnostic panel for the early detection of cachexia. Such a panel would provide a tremendous advance in cachectic patient management and in the design of clinical trials for new therapeutic interventions.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 O’Connell, Golzarri-Arroyo, Pin, Barreto, Dickinson, Couch and Bonetto.)
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فهرسة مساهمة: Keywords: biomarkers; cancer cachexia; early detection; metabolomics; muscle wasting; pre-cachexia
تواريخ الأحداث: Date Created: 20211008 Latest Revision: 20211009
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8490779
DOI: 10.3389/fcell.2021.720096
PMID: 34621740
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-634X
DOI:10.3389/fcell.2021.720096