دورية أكاديمية
أعرض في EDS

GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients.

التفاصيل البيبلوغرافية
العنوان: GAS5 rs2067079 and miR-137 rs1625579 functional SNPs and risk of chronic hepatitis B virus infection among Egyptian patients.
المؤلفون: Mahmoud RH; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Hefzy EM; Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt. emh01@fayoum.edu.eg., Shaker OG; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt., Ahmed TI; Department of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Abdelghaffar NK; Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Hassan EA; Department of Tropical Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Ibrahim AA; Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt., Ali DY; Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Mohamed MM; Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt., Abdelaleem OO; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
المصدر: Scientific reports [Sci Rep] 2021 Oct 08; Vol. 11 (1), pp. 20014. Date of Electronic Publication: 2021 Oct 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Hepatitis B, Chronic*/epidemiology , Hepatitis B, Chronic*/genetics , MicroRNAs*/analysis , MicroRNAs*/genetics , RNA, Long Noncoding*/analysis , RNA, Long Noncoding*/genetics, Adult ; Biomarkers/analysis ; Egypt/epidemiology ; Female ; Genetic Predisposition to Disease ; Hepatitis B/epidemiology ; Hepatitis B/genetics ; Humans ; Male ; Polymorphism, Single Nucleotide
مستخلص: Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their corresponding SNPs, rs2067079 (C/T) and rs1625579 (G/T) were analyzed in 117 CHBV patients and 120 controls to investigate the probable association between these biomarkers and CHBV pathogenesis in the Egyptian population. Serum expression levels of GAS5 and miR-137 were significantly down-regulated in cases vs controls. Regarding GAS5 (rs2067079), the mutant TT genotype showed an increased risk of CHBV (p < 0.001), while the dominant CC was a protective factor (p = 0.004). Regarding miR-137 rs1625579, the mutant genotype TT was reported as a risk factor for CHBV (p < 0.001) and the normal GG genotype was a protective factor, p < 0.001. The serum GAS5 was significantly higher in the mutant TT genotype of GAS5 SNP as compared to the other genotypes (p = 0.007). Concerning miR-137 rs1625579, the mutant TT genotype was significantly associated with a lower serum expression level of miR-137 (p = 0.018). We revealed the dysregulated expression levels of GAS5 and miR-137 linked to their functioning SNPs were associated with CHBV risk and might act as potential therapeutic targets.
(© 2021. The Author(s).)
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المشرفين على المادة: 0 (Biomarkers)
0 (GAS5 long non-coding RNA, human)
0 (MIRN137 microRNA, human)
0 (MicroRNAs)
0 (RNA, Long Noncoding)
تواريخ الأحداث: Date Created: 20211009 Date Completed: 20220126 Latest Revision: 20220126
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8501054
DOI: 10.1038/s41598-021-99345-2
PMID: 34625583
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-99345-2