دورية أكاديمية
Diagnostic role of lncRNA GAS5 and its genetic polymorphisms rs2067079, rs6790 and rs17359906 in rheumatoid arthritis.
العنوان: | Diagnostic role of lncRNA GAS5 and its genetic polymorphisms rs2067079, rs6790 and rs17359906 in rheumatoid arthritis. |
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المؤلفون: | Elamir AM; Medical Biochemistry Department, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt., Senara S; Department of Rheumatology and Rehabilitation, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt., Abdelghaffar NK; Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt., Gaber SN; Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt., El Sayed HS; Medical Biochemistry Department, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt. |
المصدر: | Biomedical reports [Biomed Rep] 2021 Nov; Vol. 15 (5), pp. 93. Date of Electronic Publication: 2021 Sep 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: [Spandidos Publications] Country of Publication: England NLM ID: 101613227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2049-9442 (Electronic) Linking ISSN: 20499434 NLM ISO Abbreviation: Biomed Rep Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : [Spandidos Publications], [2013]- |
مستخلص: | The aim of the present study was to detect the serum levels of long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) in patients with rheumatoid arthritis (RA) and healthy controls, and determine the association between the rs2067079, rs6790, and rs17359906 single-nucleotide polymorphisms (SNPs) of lncRNA GAS5 gene with RA risk in the Egyptian population. Reverse transcription-quantitative PCR and real-time PCR were used to measure the serum levels of lncRNA GAS5 and genotype the two distinct alleles at the SNP sites of lncRNA GAS5 gene in 200 patients with RA and 150 controls. The mean serum levels of lncRNA GAS5 were significantly lower in the patients with RA compared with the controls (P<0.0001), and the serum levels of lncRNA GAS5 were significantly negatively associated with erythrocyte sedimentation rate, C-reactive protein levels and anti-cyclic citrullinated peptide levels in the patients with RA. The TT genotype of rs2067079 SNP was significantly associated with a decreased risk of RA [TT vs. CC: Odds ratio (OR)=2.358; 95% confidence interval (CI), 1.114-5.131; P=0.045) and the risk of rs2067079 SNP reduced with a recessive pattern (TT vs. TC + CC: OR=2.374; 95% CI, 1.091-5.123; P=0.037). rs6790 SNP was associated with RA risk in the recessive model (AA vs. GA + GG: OR=2.55; 95% CI=1.39-5.32; P=0.02). No significant associations were noted between the rs17359906 SNP and RA risk (P>0.05) or between the lncRNA GAS5 levels and their respective genotypes at the three SNPs in patients with RA (all P>0.05). Based on the results of the present study, lncRNA GAS5 may serve as a biomarker for the early detection of RA. The TT genotype of rs2067079 SNP was significantly associated with a decreased risk of RA, and a reduced risk of rs2067079 SNP was observed with a recessive pattern. rs6790 SNP was associated with RA risk in the recessive model. Competing Interests: The authors declare that they have no competing interests. (Copyright © 2020, Spandidos Publications.) |
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فهرسة مساهمة: | Keywords: long non-coding RNA growth arrest-specific 5; rheumatoid arthritis; single nucleotide polymorphism |
تواريخ الأحداث: | Date Created: 20211011 Latest Revision: 20211012 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8461323 |
DOI: | 10.3892/br.2021.1469 |
PMID: | 34631048 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2049-9442 |
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DOI: | 10.3892/br.2021.1469 |