دورية أكاديمية
أعرض في EDS

Diagnostic role of lncRNA GAS5 and its genetic polymorphisms rs2067079, rs6790 and rs17359906 in rheumatoid arthritis.

التفاصيل البيبلوغرافية
العنوان: Diagnostic role of lncRNA GAS5 and its genetic polymorphisms rs2067079, rs6790 and rs17359906 in rheumatoid arthritis.
المؤلفون: Elamir AM; Medical Biochemistry Department, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt., Senara S; Department of Rheumatology and Rehabilitation, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt., Abdelghaffar NK; Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt., Gaber SN; Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt., El Sayed HS; Medical Biochemistry Department, Faculty of Medicine, Fayoum University, Fayoum 63616, Egypt.
المصدر: Biomedical reports [Biomed Rep] 2021 Nov; Vol. 15 (5), pp. 93. Date of Electronic Publication: 2021 Sep 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: [Spandidos Publications] Country of Publication: England NLM ID: 101613227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2049-9442 (Electronic) Linking ISSN: 20499434 NLM ISO Abbreviation: Biomed Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : [Spandidos Publications], [2013]-
مستخلص: The aim of the present study was to detect the serum levels of long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) in patients with rheumatoid arthritis (RA) and healthy controls, and determine the association between the rs2067079, rs6790, and rs17359906 single-nucleotide polymorphisms (SNPs) of lncRNA GAS5 gene with RA risk in the Egyptian population. Reverse transcription-quantitative PCR and real-time PCR were used to measure the serum levels of lncRNA GAS5 and genotype the two distinct alleles at the SNP sites of lncRNA GAS5 gene in 200 patients with RA and 150 controls. The mean serum levels of lncRNA GAS5 were significantly lower in the patients with RA compared with the controls (P<0.0001), and the serum levels of lncRNA GAS5 were significantly negatively associated with erythrocyte sedimentation rate, C-reactive protein levels and anti-cyclic citrullinated peptide levels in the patients with RA. The TT genotype of rs2067079 SNP was significantly associated with a decreased risk of RA [TT vs. CC: Odds ratio (OR)=2.358; 95% confidence interval (CI), 1.114-5.131; P=0.045) and the risk of rs2067079 SNP reduced with a recessive pattern (TT vs. TC + CC: OR=2.374; 95% CI, 1.091-5.123; P=0.037). rs6790 SNP was associated with RA risk in the recessive model (AA vs. GA + GG: OR=2.55; 95% CI=1.39-5.32; P=0.02). No significant associations were noted between the rs17359906 SNP and RA risk (P>0.05) or between the lncRNA GAS5 levels and their respective genotypes at the three SNPs in patients with RA (all P>0.05). Based on the results of the present study, lncRNA GAS5 may serve as a biomarker for the early detection of RA. The TT genotype of rs2067079 SNP was significantly associated with a decreased risk of RA, and a reduced risk of rs2067079 SNP was observed with a recessive pattern. rs6790 SNP was associated with RA risk in the recessive model.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2020, Spandidos Publications.)
References: Nat Genet. 2010 Jan;42(1):68-71. (PMID: 19966805)
FASEB J. 2011 Feb;25(2):444-8. (PMID: 20956613)
Neurosci Lett. 2019 May 14;701:54-57. (PMID: 30790644)
Horm Metab Res. 2016 Aug;48(8):550-7. (PMID: 27214311)
Cytokine. 2014 Jul;68(1):65-8. (PMID: 24721042)
Br Med J. 1948 Feb 28;1(4547):391-3. (PMID: 18905259)
J Clin Invest. 2015 Mar 2;125(3):1069-80. (PMID: 25642768)
Genes Immun. 2006 Apr;7(3):250-63. (PMID: 16541099)
Clin Chem. 1998 Aug;44(8 Pt 1):1748-50. (PMID: 9702967)
Semin Immunopathol. 2012 Jul;34(4):567-80. (PMID: 22580835)
Nat Genet. 2015 Mar;47(3):199-208. (PMID: 25599403)
Ann Rheum Dis. 2010 Sep;69(9):1580-8. (PMID: 20699241)
Oncotarget. 2017 Apr 4;8(14):23650-23663. (PMID: 28423570)
J Autoimmun. 2016 Dec;75:96-104. (PMID: 27481557)
Autoimmun Rev. 2015 Sep;14(9):798-805. (PMID: 25989481)
Arthritis Res Ther. 2015 May 21;17:131. (PMID: 25994030)
N Engl J Med. 2011 Dec 8;365(23):2205-19. (PMID: 22150039)
Genes Immun. 2016 Mar;17(2):85-92. (PMID: 26673966)
Clin Rheumatol. 2015 Aug;34(8):1375-82. (PMID: 25652333)
Lancet. 2001 Sep 15;358(9285):903-11. (PMID: 11567728)
Cell Death Differ. 2013 Nov;20(11):1558-68. (PMID: 23933812)
Int J Clin Exp Pathol. 2014 Jun 15;7(7):4303-9. (PMID: 25120813)
Nature. 2014 Feb 20;506(7488):376-81. (PMID: 24390342)
J Cell Mol Med. 2014 Nov;18(11):2213-24. (PMID: 25164131)
Biomolecules. 2019 Dec 29;10(1):. (PMID: 31905737)
J Orthop Res. 2014 Dec;32(12):1628-35. (PMID: 25196583)
Genes (Basel). 2015 Jul 07;6(3):484-99. (PMID: 26198250)
Clin Res Hepatol Gastroenterol. 2018 Oct;42(5):478-482. (PMID: 29602737)
Sci Rep. 2017 Nov 9;7(1):15119. (PMID: 29123179)
Endocr Metab Immune Disord Drug Targets. 2015;15(2):129-34. (PMID: 25772178)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
Sci Signal. 2010 Feb 02;3(107):ra8. (PMID: 20124551)
فهرسة مساهمة: Keywords: long non-coding RNA growth arrest-specific 5; rheumatoid arthritis; single nucleotide polymorphism
تواريخ الأحداث: Date Created: 20211011 Latest Revision: 20211012
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8461323
DOI: 10.3892/br.2021.1469
PMID: 34631048
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-9442
DOI:10.3892/br.2021.1469