تقرير
CD4 + T cells from patients with glucocorticoid-refractory immune thrombocytopenia have altered cytokine expression.
العنوان: | CD4 + T cells from patients with glucocorticoid-refractory immune thrombocytopenia have altered cytokine expression. |
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المؤلفون: | Stimpson ML; Translational Health Sciences, University of Bristol, Bristol, UK., Wolf JS; University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK., Williams EL; Translational Health Sciences, University of Bristol, Bristol, UK., Lait PJP; Translational Health Sciences, University of Bristol, Bristol, UK., Schewitz-Bowers LP; Translational Health Sciences, University of Bristol, Bristol, UK., Greenwood R; Research Design Service, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK., Pell J; Centre for Trials Research, Cardiff University, Cardiff, UK., Thomas I; Centre for Trials Research, Cardiff University, Cardiff, UK., Lee RWJ; Translational Health Sciences, University of Bristol, Bristol, UK.; Institute of Ophthalmology, Faculty of Brain Sciences, University College London, London, UK., Bradbury CA; Translational Health Sciences, University of Bristol, Bristol, UK.; University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK. |
المصدر: | British journal of haematology [Br J Haematol] 2022 Feb; Vol. 196 (4), pp. 1113-1117. Date of Electronic Publication: 2021 Oct 10. |
نوع المنشور: | Letter; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
مواضيع طبية MeSH: | CD4-Positive T-Lymphocytes/*immunology , Cytokines/*metabolism , Purpura, Thrombocytopenic, Idiopathic/*immunology, Female ; Humans ; Male ; Prospective Studies |
References: | Provan D, Arnold DM, Bussel JB, Chong BH, Cooper N, Gernsheimer T, et al. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv [Internet]. 2019 Nov 26 [cited 2021 Aug 05];3(22):3780-817. https://doi.org/10.1182/bloodadvances.2019000812. Brown TM, Horblyuk RV, Grotzinger KM, Matzdorff AC, Pashos CL. Patient-reported treatment burden of chronic immune thrombocytopenia therapies. BMC Blood Disord [internet]. 2012; Mar 22 [cited 2021 Aug 05];12:2. https://doi.org/10.1186/1471-2326-12-2. Bradbury CA, Pell J, Hill Q, Bagot C, Cooper N, Ingram J, et al. Mycophenolate Mofetil for first line treatment of immune thrombocytopenia. N Engl J Med [Internet]. 2021 Sep 2 [cited 2021 Aug 09];385(10):885-95. https://doi.org/10.1056/NEJMoa2100596. Gudbrandsdottir S, Birgens HS, Frederiksen H, Jensen BA, Jensen MK, Kjeldsen L, et al. Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia. Blood [Internet]. 2013 Mar 14 [cited 2021 Aug 05];121(11):1976-81. https://doi.org/10.1182/blood-2012-09-455691. Schewitz-Bowers LP, Lait PJ, Copland DA, Chen P, Wu W, Dhanda AD, et al. Glucocorticoid-resistant Th17 cells are selectively attenuated by cyclosporine A. Proc Natl Acad Sci U S A [Internet]. 2015 Mar 31 [cited 2021 Aug 06];112(13):4080-5. https://doi.org/10.1073/pnas.1418316112. Ramesh R, Kozhaya L, McKevitt K, Djuretic IM, Carlson TJ, Quintero MA, et al. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J Exp Med [Internet]. 2014 Jan 13 [cited 2021 Aug 13];211(1):89-104. https://doi.org/10.1084/jem.20130301. Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest [Internet]. 2006 Jan 13 [cited 2021 Aug 14];116(1):146-55. https://doi.org/10.1172/JCI21759. Stimpson ML, Lait PJ, Schewitz-Bowers LP, Williams EL, Thirlwall KF, Lee RW, et al. IL-10 and IL-17 expression by CD4+ T cells is altered in corticosteroid refractory immune thrombocytopenia (ITP). J Thromb Haemost [Internet]. 2020 Jun 23 [cited 2021 Aug 09];18(10):2712-20. https://doi.org/10.1111/jth.14970. Pell J, Greenwood R, Ingram J, Wale K, Thomas I, Kandiyali R, et al. Trial protocol: a multicentre randomised trial of first-line treatment pathways for newly diagnosed immune thrombocytopenia: standard steroid treatment versus combined steroid and mycophenolate. The FLIGHT Trial. BMJ Open [internet]. 2018; [cited 2021 Aug 06];8(10):e024427. https://doi.org/10.1136/bmjopen-2018-024427. Richards DF, Fernandez M, Caulfield J, Hawrylowicz CM. Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production. Eur J Immunol [Internet]. 2000 Aug [cited 2021 Aug 13];30(8):2344-54. https://doi.org/10.1002/1521-4141(2000)30:8<2344::AID-IMMU2344>3.0.CO;2-7. Ma L, Simpson E, Li J, Xuan M, Xu M, Baker L, et al. CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia. Blood [Internet]. 2015 Jul 9 [cited 2021 Aug 14];126(2):247-56. https://doi.org/10.1182/blood-2015-03-635417. Hua F, Ji L, Zhan Y, Li F, Zou S, Wang X, et al. Pulsed high-dose dexamethasone improves interleukin 10 secretion by CD5+ B cells in patients with primary immune thrombocytopenia. J Clin Immunol [Internet]. 2012 Dec [cited 2021 Aug 13];32(6):1233-42. https://doi.org/10.1007/s10875-012-9714-z. Mann EH, Gabryšová L, Pfeffer PE, O'Garra A, Hawrylowicz CM. High-dose IL-2 skews a glucocorticoid-driven IL-17+IL-10+ memory CD4+ T cell response towards a single IL-10-producing phenotype. J Immunol [Internet]. 2019 Feb 1 [cited 2021 Aug 15];202(3):684-93. https://doi.org/10.4049/jimmunol.1800697. McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol [Internet]. 2007 Dec [cited 2021 Aug 08];8(12):1390-7. https://doi.org/10.1038/ni1539. |
فهرسة مساهمة: | Keywords: ITP; biomarker; cytokines; glucocorticoids; lymphocytes |
المشرفين على المادة: | 0 (Cytokines) |
تواريخ الأحداث: | Date Created: 20211011 Date Completed: 20220301 Latest Revision: 20220301 |
رمز التحديث: | 20240628 |
DOI: | 10.1111/bjh.17884 |
PMID: | 34632576 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1365-2141 |
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DOI: | 10.1111/bjh.17884 |