دورية أكاديمية
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.
العنوان: | Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6. |
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المؤلفون: | Ranson JM; College of Medicine and Health, University of Exeter, Exeter, UK.; Deep Dementia Phenotyping (DEMON) Network, Exeter, UK., Rittman T; Deep Dementia Phenotyping (DEMON) Network, Exeter, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Hayat S; Department of Public Health and Primary Care, Cambridge Public Health, University of Cambridge, Cambridge, UK., Brayne C; Department of Public Health and Primary Care, Cambridge Public Health, University of Cambridge, Cambridge, UK., Jessen F; Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., van Duijn C; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Barkhof F; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Tang E; Deep Dementia Phenotyping (DEMON) Network, Exeter, UK.; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Mummery CJ; Deep Dementia Phenotyping (DEMON) Network, Exeter, UK.; Dementia Research Centre, Institute of Neurology, University College London, and National Hospital for Neurology and Neurosurgery, University College London Hospital, London, UK., Stephan BCM; Institute of Mental Health, Division of Psychiatry and Applied Psychology, School of Medicine, Nottingham University, Nottingham, UK., Altomare D; Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.; Memory Clinic, Geneva University Hospitals, Geneva, Switzerland., Frisoni GB; Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.; Memory Clinic, Geneva University Hospitals, Geneva, Switzerland., Ribaldi F; Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.; Memory Clinic, Geneva University Hospitals, Geneva, Switzerland.; Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE), Saint John of God Clinical Research Centre, Brescia, Italy.; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Molinuevo JL; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Life Science Partners, Amsterdam, The Netherlands., Llewellyn DJ; College of Medicine and Health, University of Exeter, Exeter, UK. david.llewellyn@exeter.ac.uk.; Deep Dementia Phenotyping (DEMON) Network, Exeter, UK. david.llewellyn@exeter.ac.uk.; Alan Turing Institute, London, UK. david.llewellyn@exeter.ac.uk.; 2.04 College House, St Luke's Campus, University of Exeter Medical School, Exeter, EX1 2 LU, UK. david.llewellyn@exeter.ac.uk. |
مؤلفون مشاركون: | European Task Force for Brain Health Services |
المصدر: | Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Oct 11; Vol. 13 (1), pp. 169. Date of Electronic Publication: 2021 Oct 11. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : BioMed Central Ltd. |
مواضيع طبية MeSH: | Alzheimer Disease* , Dementia*/diagnostic imaging , Dementia*/epidemiology , Dementia*/genetics, Aged ; Artificial Intelligence ; Australia ; Biomarkers ; Brain/diagnostic imaging ; Health Services ; Humans ; Middle Aged ; Positron-Emission Tomography ; Risk Factors |
مستخلص: | We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the focus is on risk profiling and personalized risk reduction interventions rather than diagnosing and treating late-stage disease. In this article, we review key potentially modifiable risk factors and genetic risk factors and discuss assessment of risk factors as well as additional fluid and imaging biomarkers that may enhance risk profiling. We then outline multidomain measures and risk profiling and provide practical guidelines for Brain Health Services, with consideration of outstanding uncertainties and challenges. Users of Brain Health Services should undergo risk profiling tailored to their age, level of risk, and availability of local resources. Initial risk assessment should incorporate a multidomain risk profiling measure. For users aged 39-64, we recommend the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) Dementia Risk Score, whereas for users aged 65 and older, we recommend the Brief Dementia Screening Indicator (BDSI) and the Australian National University Alzheimer's Disease Risk Index (ANU-ADRI). The initial assessment should also include potentially modifiable risk factors including sociodemographic, lifestyle, and health factors. If resources allow, apolipoprotein E ɛ4 status testing and structural magnetic resonance imaging should be conducted. If this initial assessment indicates a low dementia risk, then low intensity interventions can be implemented. If the user has a high dementia risk, additional investigations should be considered if local resources allow. Common variant polygenic risk of late-onset AD can be tested in middle-aged or older adults. Rare variants should only be investigated in users with a family history of early-onset dementia in a first degree relative. Advanced imaging with 18-fluorodeoxyglucose positron emission tomography (FDG-PET) or amyloid PET may be informative in high risk users to clarify the nature and burden of their underlying pathologies. Cerebrospinal fluid biomarkers are not recommended for this setting, and blood-based biomarkers need further validation before clinical use. As new technologies become available, advances in artificial intelligence are likely to improve our ability to combine diverse data to further enhance risk profiling. Ultimately, Brain Health Services have the potential to reduce the future burden of dementia through risk profiling, risk communication, personalized risk reduction, and cognitive enhancement interventions. (© 2021. The Author(s).) |
References: | Sci Rep. 2016 May 31;6:26801. (PMID: 27241045) Nat Genet. 2019 Mar;51(3):414-430. (PMID: 30820047) Alzheimers Res Ther. 2021 Oct 11;13(1):171. (PMID: 34635167) Nat Commun. 2020 Feb 3;11(1):667. (PMID: 32015339) JAMA Neurol. 2018 Apr 1;75(4):462-470. (PMID: 29356827) Sci Rep. 2019 Sep 20;9(1):13622. (PMID: 31541187) Nat Med. 2019 Feb;25(2):277-283. (PMID: 30664784) J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):967-72. (PMID: 1431963) Subst Abuse Treat Prev Policy. 2018 Feb 2;13(1):6. (PMID: 29394950) Alzheimers Dement. 2014 Nov;10(6):656-665.e1. (PMID: 24491321) Lancet Neurol. 2013 Aug;12(8):822-38. (PMID: 23867200) Prev Sci. 2013 Aug;14(4):411-21. (PMID: 23319292) Ann N Y Acad Sci. 2011 Aug;1231:17-22. (PMID: 21651565) J Alzheimers Dis. 2019;70(s1):S145-S163. (PMID: 30775976) Neuroradiology. 2019 Jun;61(6):633-642. (PMID: 30852630) Lancet. 2015 Jun 6;385(9984):2255-63. (PMID: 25771249) JAMA. 2020 Aug 25;324(8):772-781. (PMID: 32722745) Lancet Neurol. 2018 May;17(5):434-444. (PMID: 29555425) Neurology. 2017 Nov 21;89(21):2167-2175. (PMID: 29070659) J Acad Nutr Diet. 2014 Feb;114(2):199-208. (PMID: 24290836) Neurobiol Aging. 2010 Aug;31(8):1275-83. (PMID: 20472326) Alzheimers Res Ther. 2021 Oct 11;13(1):172. (PMID: 34635149) Eur Heart J. 2020 Jan 7;41(2):255-323. (PMID: 31497854) J Neurol. 2020 Nov;267(11):3429-3435. (PMID: 32638104) Biol Psychiatry. 2017 Dec 1;82(11):e81-e83. (PMID: 29110819) Neurology. 2018 Mar 20;90(12):e1029-e1037. (PMID: 29453242) Lancet Diabetes Endocrinol. 2013 Nov;1(3):183-90. (PMID: 24622366) Nat Rev Neurol. 2010 Feb;6(2):67-77. (PMID: 20139996) Psychosomatics. 1993 Jan-Feb;34(1):61-9. (PMID: 8426892) AJR Am J Roentgenol. 1987 Aug;149(2):351-6. (PMID: 3496763) Stroke. 2001 Jun;32(6):1318-22. (PMID: 11387493) PLoS One. 2015 Sep 03;10(9):e0136181. (PMID: 26334524) Alzheimers Res Ther. 2011 Jan 06;3(1):1. (PMID: 21211070) J Head Trauma Rehabil. 2007 Nov-Dec;22(6):318-29. (PMID: 18025964) J Neurosci. 2011 Aug 31;31(35):12638-43. (PMID: 21880924) J Neurol Neurosurg Psychiatry. 2019 Apr;90(4):373-379. (PMID: 29954871) Neurology. 2014 Jul 15;83(3):253-60. (PMID: 24928124) Eur J Hum Genet. 2017 Aug;25(8):973-981. (PMID: 28537274) Curr Psychiatry Rev. 2009 May 1;5(2):73-92. (PMID: 19946443) J Nucl Med. 2016 May;57(5):777-84. (PMID: 26848175) Alzheimers Res Ther. 2021 Oct 11;13(1):170. (PMID: 34635169) Acta Neuropathol Commun. 2016 Jun 13;4(1):58. (PMID: 27296779) Alzheimers Dement. 2018 Nov;14(11):1505-1521. (PMID: 30316776) Nat Med. 2020 Mar;26(3):387-397. (PMID: 32123386) Eur Radiol. 2011 Dec;21(12):2618-25. (PMID: 21805370) BMJ. 2019 Apr 17;365:l1495. (PMID: 30995986) Alzheimers Dement. 2020 Oct;16(10):1457-1468. (PMID: 32815289) Neuroimage Clin. 2020;26:102199. (PMID: 32106025) BMC Geriatr. 2016 Oct 12;16(1):175. (PMID: 27729011) Geriatrics (Basel). 2018 Aug 02;3(3):. (PMID: 31011085) PLoS One. 2014 Jan 23;9(1):e86141. (PMID: 24465922) JAMA. 2019 Aug 06;322(5):430-437. (PMID: 31302669) Lancet. 2020 Aug 8;396(10248):413-446. (PMID: 32738937) Neuroimage Clin. 2019;24:101954. (PMID: 31362149) Lancet. 2017 Dec 16;390(10113):2673-2734. (PMID: 28735855) Alzheimers Res Ther. 2021 Oct 11;13(1):168. (PMID: 34635163) Lancet Neurol. 2010 Aug;9(8):793-806. (PMID: 20650401) Nat Commun. 2020 Nov 27;11(1):6024. (PMID: 33247134) JAMA. 2020 Jun 9;323(22):2290-2300. (PMID: 32515813) N Engl J Med. 2012 Aug 30;367(9):795-804. (PMID: 22784036) Arch Neurol. 1998 Jul;55(7):964-8. (PMID: 9678314) World J Diabetes. 2015 Oct 10;6(13):1246-58. (PMID: 26468341) Ann Neurol. 2003 Feb;53(2):181-8. (PMID: 12557284) J Nucl Med. 2009 Aug;50(8):1276-82. (PMID: 19617321) Nat Med. 2020 Mar;26(3):379-386. (PMID: 32123385) BMJ. 2010 Jul 26;341:c3666. (PMID: 20660506) Ann Behav Med. 2018 May 31;52(7):582-593. (PMID: 29860361) Mol Psychiatry. 2011 Sep;16(9):903-7. (PMID: 21556001) Lancet Glob Health. 2020 Apr;8(4):e524-e535. (PMID: 32199121) Lancet Neurol. 2006 Sep;5(9):735-41. (PMID: 16914401) Cochrane Database Syst Rev. 2020 Mar 2;3:CD009628. (PMID: 32119112) Int J Geriatr Psychiatry. 2015 Mar;30(3):234-46. (PMID: 25504093) Front Aging Neurosci. 2015 Aug 10;7:134. (PMID: 26321944) Lancet. 1996 Jul 13;348(9020):94-7. (PMID: 8676724) Eur Heart J. 2018 Sep 1;39(33):3021-3104. (PMID: 30165516) Brain. 2019 Feb 1;142(2):460-470. (PMID: 30689776) Alzheimer Dis Assoc Disord. 2011 Oct-Dec;25(4):289-304. (PMID: 21750453) Alzheimers Dement. 2018 Nov;14(11):1482-1492. (PMID: 29792871) Neurology. 1996 Mar;46(3):673-7. (PMID: 8618665) Lancet Neurol. 2015 Mar;14(3):253-62. (PMID: 25662776) Alzheimers Dement. 2014 Jul;10(4):421-429.e3. (PMID: 24985687) Eur Neurol. 1996;36(5):268-72. (PMID: 8864706) Nat Aging. 2021 Jan;1(1):114-123. (PMID: 37117993) BMJ. 2009 Jul 06;339:b2477. (PMID: 19581317) Nat Med. 2019 Sep;25(9):1364-1369. (PMID: 31451782) Nat Commun. 2020 Sep 7;11(1):4340. (PMID: 32895386) PLoS Med. 2017 Mar 21;14(3):e1002258. (PMID: 28323831) Lancet Neurol. 2020 May;19(5):422-433. (PMID: 32333900) Brain. 2015 Dec;138(Pt 12):3673-84. (PMID: 26490334) JAMA Neurol. 2017 May 1;74(5):557-566. (PMID: 28346578) Stroke. 2020 Jul;51(7):2095-2102. (PMID: 32568644) World J Biol Psychiatry. 2018 Jun;19(4):244-328. (PMID: 29076399) JAMA Neurol. 2019 Sep 01;76(9):1060-1069. (PMID: 31233127) Cereb Cortex. 2009 Mar;19(3):497-510. (PMID: 18632739) Alzheimers Res Ther. 2021 Oct 11;13(1):173. (PMID: 34635173) Alzheimers Dement. 2018 Nov;14(11):1416-1426. (PMID: 30177276) |
معلومات مُعتمدة: | G0601022 United Kingdom MRC_ Medical Research Council; G9901400 United Kingdom MRC_ Medical Research Council; RF1 AG055654 United States AG NIA NIH HHS; United Kingdom DH_ Department of Health |
فهرسة مساهمة: | Investigator: M Abramowicz; D Altomare; F Barkhof; M Berthier; M Bieler; K Blennow; C Brayne; A Brioschi; E Carrera; G Chételat; C Csajka; JF Demonet; A Dodich; B Dubois; GB Frisoni; V Garibotto; J Georges; S Hurst; F Jessen; M Kivipelto; D J Llewellyn; L McWhirter; R Milne; C Minguillón; C Miniussi; JL Molinuevo; PM Nilsson; JM Ranson; F Ribaldi; C Ritchie; P Scheltens; A Solomon; W van der Flier; C van Duijn; B Vellas; L Visser Keywords: Aging; Alzheimer’s disease; Brain health services; Dementia; Prevention; Public health; Risk factors; Risk profiling |
المشرفين على المادة: | 0 (Biomarkers) |
تواريخ الأحداث: | Date Created: 20211012 Date Completed: 20211028 Latest Revision: 20240403 |
رمز التحديث: | 20240403 |
مُعرف محوري في PubMed: | PMC8507172 |
DOI: | 10.1186/s13195-021-00895-4 |
PMID: | 34635138 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1758-9193 |
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DOI: | 10.1186/s13195-021-00895-4 |