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Effects of Bushen-Tiaojing-Fang on the pregnancy outcomes of infertile patients with repeated controlled ovarian stimulation.

التفاصيل البيبلوغرافية
العنوان: Effects of Bushen-Tiaojing-Fang on the pregnancy outcomes of infertile patients with repeated controlled ovarian stimulation.
المؤلفون: Ma YC; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China., Hao GM; Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China., Zhao ZM; Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China., Cui N; Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China., Fan YL; Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China., Zhang SC; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China., Chen JW; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China., Cao YC; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China., Guan FL; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China., Geng JR; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China., Gao BL; Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China., Du HL; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China. duhuilan@hebcm.edu.cn.
المصدر: Scientific reports [Sci Rep] 2021 Oct 11; Vol. 11 (1), pp. 15233. Date of Electronic Publication: 2021 Oct 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Drugs, Chinese Herbal/*therapeutic use , Infertility, Female/*therapy , Ovulation Induction/*methods, Adenosine Triphosphate/metabolism ; Adult ; Embryo Implantation/physiology ; Female ; Follicular Fluid/metabolism ; Glutathione Peroxidase/metabolism ; Humans ; Infertility, Female/metabolism ; Mitochondria/metabolism ; NF-E2-Related Factor 2/metabolism ; Pregnancy ; Pregnancy Outcome ; Superoxide Dismutase/metabolism
مستخلص: Bushen-Tiaojing-Fang (BSTJF) is commonly used to treat infertility. This study investigated the effects of BSTJF on the pregnancy outcomes of patients with repeated controlled ovarian stimulation (COS), on mitochondrial function, and on oxidative stress in ovarian granulosa cells (GCs) and follicular fluid (FF). The samples and clinical data of 97 patients, including 35 in the control group, 29 in the placebo group and 33 in the BSTJF group, were collected for this study. The mitochondrial ultrastructure, ATP content, mitochondrial DNA (mtDNA) number, 8-hydroxy-2-deoxyguanosine (8-OHdG), Mn-superoxide dismutase (Mn-SOD), glutathione peroxidase (GSH-Px) activity levels, and mRNA expression levels of Mn-SOD, GSH-Px, and nuclear factor erythroid-derived factor 2-related factor 2 (Nrf2) were analyzed. The high-grade embryo (P < 0.001), implantation (P = 0.033), and clinical pregnancy (P = 0.031) rates, as well as the ATP content (P = 0.014), mtDNA number (P = 0.035), GSH-Px activity (P = 0.004 in GCs and P = 0.008 in FF) and mRNA expression levels (P = 0.019), were significantly lower in the placebo group than in the control group, whereas the 8-OHdG content was significantly (P = 0.006 in FF) higher in the placebo group than in the control group. Compared with those in the placebo group, the high-grade embryo rate (P = 0.007), antioxidant enzyme activity (P = 0.037 and 0.036 in Mn-SOD; P = 0.047 and 0.030 in GSH-Px) and mRNA level (P < 0.001 in Nrf2, P = 0.039 in Mn-SOD and P = 0.002 in GSH-Px) were significantly higher in the BSTJF group, as were changes in mitochondrial ultrastructure, ATP (P = 0.040) and mtDNA number (P = 0.013). In conclusion, BSTJF can improve oxidative stress in patients with repeated COS and pregnancy outcomes.
(© 2021. The Author(s).)
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المشرفين على المادة: 0 (Bushen formula)
0 (Drugs, Chinese Herbal)
0 (NF-E2-Related Factor 2)
0 (NFE2L2 protein, human)
8L70Q75FXE (Adenosine Triphosphate)
EC 1.11.1.9 (Glutathione Peroxidase)
EC 1.15.1.1 (Superoxide Dismutase)
تواريخ الأحداث: Date Created: 20211012 Date Completed: 20211109 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC8505422
DOI: 10.1038/s41598-021-94366-3
PMID: 34635680
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-94366-3