دورية أكاديمية
Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial.
| العنوان: | Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial. |
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| المؤلفون: | Spoormans EM; Department of Cardiology, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands., Lemkes JS; Department of Cardiology, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands., Janssens GN; Department of Cardiology, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands., van der Hoeven NW; Department of Cardiology, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands., Jewbali LSD; Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands., Dubois EA; Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Intensive Care Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Meuwissen M; Department of Cardiology, Amphia Hospital, Breda, The Netherlands., Rijpstra TA; Department of Intensive Care Medicine, Amphia Hospital, Breda, The Netherlands., Bosker HA; Department of Cardiology, Rijnstate Hospital, Arnhem, The Netherlands., Blans MJ; Department of Intensive Care Medicine, Rijnstate Hospital, Arnhem, The Netherlands., Bleeker GB; Department of Cardiology, HAGA Hospital, Den Haag, The Netherlands., Baak R; Department of Intensive Care Medicine, HAGA Hospital, Den Haag, The Netherlands., Vlachojannis GJ; Department of Cardiology, Maasstad Hospital, Rotterdam, The Netherlands.; Department of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands., Eikemans BJW; Department of Intensive Care Medicine, Maasstad Hospital, Rotterdam, The Netherlands., Girbes ARJ; Department of Intensive Care Medicine, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., van der Horst ICC; Department of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands.; Department of Intensive Care Medicine, Maastricht University Medical Center, University Maastricht, Maastricht, The Netherlands., Voskuil M; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., van der Heijden JJ; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Beishuizen A; Department of Intensive Care Medicine, Medisch Spectrum Twente, Enschede, The Netherlands., Stoel M; Department of Cardiology, Medisch Spectrum Twente, Enschede, The Netherlands., Camaro C; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands., van der Hoeven H; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Henriques JP; Department of Cardiology, Amsterdam University Medical Center, location AMC, Amsterdam, The Netherlands., Vlaar APJ; Department of Intensive Care Medicine, Amsterdam University Medical Center, location AMC, Amsterdam, The Netherlands., Vink MA; Department of Cardiology, OLVG, Amsterdam, The Netherlands., van den Bogaard B; Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands., Heestermans TACM; Department of Cardiology, Noord West Ziekenhuisgroep, Alkmaar, The Netherlands., de Ruijter W; Department of Intensive Care Medicine, Noord West Ziekenhuisgroep, Alkmaar, The Netherlands., Delnoij TSR; Department of Intensive Care Medicine, Maastricht University Medical Center, University Maastricht, Maastricht, The Netherlands., Crijns HJGM; Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands., Jessurun GAJ; Department of Cardiology, Scheper Hospital, Emmen, The Netherlands., Oemrawsingh PV; Department of Cardiology, Haaglanden Medical Center, Den Haag, The Netherlands., Gosselink MTM; Department of Cardiology, Isala Hospital, Zwolle, The Netherlands., Plomp K; Department of Cardiology, Tergooi Hospital, Blaricum, The Netherlands., Magro M; Department of Cardiology, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands., van de Ven PM; Department of Epidemiology and Data Science, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands., van Royen N; Department of Cardiology, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands.; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands., Elbers PWG; Department of Intensive Care Medicine, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands. |
| المصدر: | Critical care medicine [Crit Care Med] 2022 Feb 01; Vol. 50 (2), pp. e129-e142. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0355501 Publication Model: Print Cited Medium: Internet ISSN: 1530-0293 (Electronic) Linking ISSN: 00903493 NLM ISO Abbreviation: Crit Care Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia, PA : Lippincott Williams & Wilkins Original Publication: New York, Kolen. |
| مواضيع طبية MeSH: | Coronary Angiography/*methods , Electric Countershock/*statistics & numerical data , Hypothermia, Induced/*standards , Out-of-Hospital Cardiac Arrest/*therapy, Aged ; Coronary Angiography/statistics & numerical data ; Female ; Humans ; Hypothermia, Induced/methods ; Hypothermia, Induced/statistics & numerical data ; Male ; Middle Aged ; Netherlands ; Out-of-Hospital Cardiac Arrest/epidemiology ; Resuscitation/methods ; Resuscitation/statistics & numerical data ; Treatment Outcome |
| مستخلص: | Objectives: The optimal targeted temperature in patients with shockable rhythm is unclear, and current guidelines recommend targeted temperature management with a correspondingly wide range between 32°C and 36°C. Our aim was to study survival and neurologic outcome associated with targeted temperature management strategy in postarrest patients with initial shockable rhythm. Design: Observational substudy of the Coronary Angiography after Cardiac Arrest without ST-segment Elevation trial. Setting: Nineteen hospitals in The Netherlands. Patients: The Coronary Angiography after Cardiac Arrest trial randomized successfully resuscitated patients with shockable rhythm and absence of ST-segment elevation to a strategy of immediate or delayed coronary angiography. In this substudy, 459 patients treated with mild therapeutic hypothermia (32.0-34.0°C) or targeted normothermia (36.0-37.0°C) were included. Allocation to targeted temperature management strategy was at the discretion of the physician. Interventions: None. Measurements and Main Results: After 90 days, 171 patients (63.6%) in the mild therapeutic hypothermia group and 129 (67.9%) in the targeted normothermia group were alive (hazard ratio, 0.86 [95% CI, 0.62-1.18]; log-rank p = 0.35; adjusted odds ratio, 0.89; 95% CI, 0.45-1.72). Patients in the mild therapeutic hypothermia group had longer ICU stay (4 d [3-7 d] vs 3 d [2-5 d]; ratio of geometric means, 1.32; 95% CI, 1.15-1.51), lower blood pressures, higher lactate levels, and increased need for inotropic support. Cerebral Performance Category scores at ICU discharge and 90-day follow-up and patient-reported Mental and Physical Health Scores at 1 year were similar in the two groups. Conclusions: In the context of out-of-hospital cardiac arrest with shockable rhythm and no ST-elevation, treatment with mild therapeutic hypothermia was not associated with improved 90-day survival compared with targeted normothermia. Neurologic outcomes at 90 days as well as patient-reported Mental and Physical Health Scores at 1 year did not differ between the groups. Competing Interests: Dr. Lemkes received funding from The Netherlands Heart Institute (NHLI) and Biotronik. Drs. Lemkes and Vlachojannis received funding from AstraZeneca. Dr. Rijpstra’s institution received funding from Principle Investigator. Dr. Vlachojannis’ institution received funding from MicroPort and Daiichi Sankyo; he received funding from Abbott. Dr. Vlachojannis reports receiving grant support from MicroPort Orthopedics and Daiichi Sankyo. Dr. van Royen’s institution received funding from Biotronik, AstraZeneca, the NHLI, Abbott, and Medtronic; he received funding from Novartis, MicroPort, Castor, Rainmed, Biotronik, Abbott, Medtronic, and Philips; he received support for article research from the NLHI. The remaining authors have disclosed that they do not have any potential conflicts of interest. (Copyright © 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.) |
| References: | Patel N, Patel NJ, Macon CJ, et al.: Trends and outcomes of coronary angiography and percutaneous coronary intervention after out-of-hospital cardiac arrest associated with ventricular fibrillation or pulseless ventricular tachycardia. JAMA Cardiol. 2016; 1:890–899. Neumar RW, Nolan JP, Adrie C, et al.: Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation. 2008; 118:2452–2483. Nolan JP, Soar J, Cariou A, et al.; European Resuscitation Council; European Society of Intensive Care Medicine: European Resuscitation Council and European Society of Intensive Care Medicine 2015 guidelines for post-resuscitation care. Intensive Care Med. 2015; 41:2039–2056. Diringer MN, Reaven NL, Funk SE, et al.: Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Crit Care Med. 2004; 32:1489–1495. Langhelle A, Tyvold SS, Lexow K, et al.: In-hospital factors associated with improved outcome after out-of-hospital cardiac arrest. A comparison between four regions in Norway. Resuscitation. 2003; 56:247–263. Takasu A, Saitoh D, Kaneko N, et al.: Hyperthermia: Is it an ominous sign after cardiac arrest? Resuscitation. 2001; 49:273–277. Busto R, Globus MY, Dietrich WD, et al.: Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke. 1989; 20:904–910. Opie LH: Reperfusion injury and its pharmacologic modification. Circulation. 1989; 80:1049–1062. White BC, Grossman LI, Krause GS: Brain injury by global ischemia and reperfusion: A theoretical perspective on membrane damage and repair. Neurology. 1993; 43:1656–1665. Bernard SA, Gray TW, Buist MD, et al.: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002; 346:557–563. Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002; 346:549–556. Ibanez B, James S, Agewall S, et al.; ESC Scientific Document Group: 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018; 39:119–177. Nielsen N, Wetterslev J, Cronberg T, et al.; TTM Trial Investigators: Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med. 2013; 369:2197–2206. Bradley SM, Liu W, McNally B, et al.; Cardiac Arrest Registry to Enhance Survival (CARES) Surveillance Group: Temporal trends in the use of therapeutic hypothermia for out-of-hospital cardiac arrest. JAMA Netw Open. 2018; 1:e184511. Lascarrou JB, Dumas F, Bougouin W, et al.; SDEC: Temporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: Insights from the Paris Sudden Death Expertise Centre. Crit Care. 2019; 23:391. Salter R, Bailey M, Bellomo R, et al.; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation (ANZICS-CORE): Changes in temperature management of cardiac arrest patients following publication of the target temperature management trial. Crit Care Med. 2018; 46:1722–1730. Lemkes JS, Janssens GN, van der Hoeven NW, et al.: Coronary angiography after cardiac arrest without ST-segment elevation. N Engl J Med. 2019; 380:1397–1407. Lemkes JS, Janssens GN, van der Hoeven NW, et al.: Coronary angiography after cardiac arrest without ST segment elevation: One-year outcomes of the COACT randomized clinical trial. JAMA Cardiol. 2020; 5:1358–1365. Vandenbroucke JP, von Elm E, Altman DG, et al.; STROBE initiative: Strengthening the reporting of observational studies in epidemiology (STROBE): Explanation and elaboration. Ann Intern Med. 2007; 147:W163–W194. Hays RD, Sherbourne CD, Mazel RM: The RAND 36-Item Health Survey 1.0. Health Econ. 1993; 2:217–227. Lascarrou JB, Merdji H, Le Gouge A, et al.; CRICS-TRIGGERSEP Group: Targeted temperature management for cardiac arrest with nonshockable rhythm. N Engl J Med. 2019; 381:2327–2337. Annborn M, Bro-Jeppesen J, Nielsen N, et al.; TTM-Trial Investigators: The association of targeted temperature management at 33 and 36 °C with outcome in patients with moderate shock on admission after out-of-hospital cardiac arrest: A post hoc analysis of the target temperature management trial. Intensive Care Med. 2014; 40:1210–1219. Kirkegaard H, Søreide E, de Haas I, et al.: Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: A randomized clinical trial. JAMA. 2017; 318:341–350. Bro-Jeppesen J, Annborn M, Hassager C, et al.; TTM Investigators: Hemodynamics and vasopressor support during targeted temperature management at 33°C Versus 36°C after out-of-hospital cardiac arrest: A post hoc study of the target temperature management trial*. Crit Care Med. 2015; 43:318–327. Hollenbeck RD, McPherson JA, Mooney MR, et al.: Early cardiac catheterization is associated with improved survival in comatose survivors of cardiac arrest without STEMI. Resuscitation. 2014; 85:88–95. Erlinge D, Götberg M, Lang I, et al.: Rapid endovascular catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. The CHILL-MI trial: A randomized controlled study of the use of central venous catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. J Am Coll Cardiol. 2014; 63:1857–1865. Moulaert VR, Verbunt JA, van Heugten CM, et al.: Cognitive impairments in survivors of out-of-hospital cardiac arrest: A systematic review. Resuscitation. 2009; 80:297–305. Moulaert VR, Wachelder EM, Verbunt JA, et al.: Determinants of quality of life in survivors of cardiac arrest. J Rehabil Med. 2010; 42:553–558. Cronberg T, Lilja G, Horn J, et al.; TTM Trial Investigators: Neurologic function and health-related quality of life in patients following targeted temperature management at 33°C vs 36°C after out-of-hospital cardiac arrest: A randomized clinical trial. JAMA Neurol. 2015; 72:634–641. Grejs AM, Gjedsted J, Thygesen K, et al.: The extent of myocardial injury during prolonged targeted temperature management after out-of-hospital cardiac arrest. Am J Med. 2017; 130:37–46. Dankiewicz J, Cronberg T, Lilja G, et al.; TTM2 Trial Investigators: Hypothermia versus normothermia after out-of-hospital cardiac arrest. N Engl J Med. 2021; 384:2283–2294. |
| تواريخ الأحداث: | Date Created: 20211012 Date Completed: 20220228 Latest Revision: 20220228 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/CCM.0000000000005271 |
| PMID: | 34637414 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1530-0293 |
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| DOI: | 10.1097/CCM.0000000000005271 |