دورية أكاديمية
أعرض في EDS

Bruguiera gymnorhiza (L.) Lam. at the Forefront of Pharma to Confront Zika Virus and Microbial Infections-An In Vitro and In Silico Perspective.

التفاصيل البيبلوغرافية
العنوان: Bruguiera gymnorhiza (L.) Lam. at the Forefront of Pharma to Confront Zika Virus and Microbial Infections-An In Vitro and In Silico Perspective.
المؤلفون: Bibi Sadeer N; Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit 80837, Mauritius., Haddad JG; Unité Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Université de la Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, 94791 Sainte Clotilde, La Réunion, France., Oday Ezzat M; Department of Chemistry, College of Education for Women, University of Anbar, Ramadi 31001, Iraq., Desprès P; Unité Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Université de la Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, 94791 Sainte Clotilde, La Réunion, France., Abdallah HH; Chemistry Department, College of Education, Salahaddin University-Erbil, Erbil 44001, Iraq., Zengin G; Department of Biology, Science Faculty, Selcuk University, Campus, 42130 Konya, Turkey., Uysal A; Department of Medicinal Laboratory, Vocational School of Health Services, Selcuk University, 42130 Konya, Turkey., El Kalamouni C; Unité Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Université de la Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, 94791 Sainte Clotilde, La Réunion, France., Gallo M; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, via Pansini 5, 80131 Naples, Italy., Montesano D; Department of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Mahomoodally MF; Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit 80837, Mauritius.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Sep 23; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Antifungal Agents/*pharmacology , Antiviral Agents/*pharmacology , Plant Extracts/*pharmacology , Rhizophoraceae/*chemistry , Zika Virus/*growth & development, Anti-Bacterial Agents/chemistry ; Antifungal Agents/chemistry ; Antiviral Agents/chemistry ; Brazil ; Candida albicans/drug effects ; Candida albicans/growth & development ; Computer Simulation ; Drug Synergism ; Escherichia coli/drug effects ; Escherichia coli/growth & development ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/growth & development ; Mauritius ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Plant Extracts/chemistry ; Proteus mirabilis/drug effects ; Proteus mirabilis/growth & development ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/growth & development ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/growth & development ; Zika Virus/drug effects
مستخلص: The recent emergence of Zika virus (ZIKV) in Brazil and the increasing resistance developed by pathogenic bacteria to nearly all existing antibiotics should be taken as a wakeup call for the international authority as this represents a risk for global public health. The lack of antiviral drugs and effective antibiotics on the market triggers the need to search for safe therapeutics from medicinal plants to fight viral and microbial infections. In the present study, we investigated whether a mangrove plant, Bruguiera gymnorhiza (L.) Lam. ( B. gymnorhiza ) collected in Mauritius, possesses antimicrobial and antibiotic potentiating abilities and exerts anti-ZIKV activity at non-cytotoxic doses. Microorganisms Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 70603, methicillin-resistant Staphylococcus aureus ATCC 43300 (MRSA), Salmonella enteritidis ATCC 13076, Sarcina lutea ATCC 9341, Proteus mirabilis ATCC 25933, Bacillus cereus ATCC 11778 and Candida albicans ATCC 26555 were used to evaluate the antimicrobial properties. Ciprofloxacin, chloramphenicol and streptomycin antibiotics were used for assessing antibiotic potentiating activity. ZIKV MC-MR766NIID (ZIKV GFP ) was used for assessing anti-ZIKV activity. In silico docking (Autodock 4) and ADME (SwissADME) analyses were performed on collected data. Antimicrobial results revealed that Bruguiera twig ethyl acetate (BTE) was the most potent extract inhibiting the growth of all nine microbes tested, with minimum inhibitory concentrations ranging from 0.19-0.39 mg/mL. BTE showed partial synergy effects against MRSA and Pseudomonas aeruginosa when applied in combination with streptomycin and ciprofloxacin, respectively. By using a recombinant ZIKV-expressing reporter GFP protein, we identified both Bruguiera root aqueous and Bruguiera fruit aqueous extracts as potent inhibitors of ZIKV infection in human epithelial A549 cells. The mechanisms by which such extracts prevented ZIKV infection are linked to the inability of the virus to bind to the host cell surface. In silico docking showed that ZIKV E protein, which is involved in cell receptor binding, could be a target for cryptochlorogenic acid, a chemical compound identified in B. gymnorhiza . From ADME results, cryptochlorogenic acid is predicted to be not orally bioavailable because it is too polar. Scientific data collected in this present work can open a new avenue for the development of potential inhibitors from B. gymnorhiza to fight ZIKV and microbial infections in the future.
References: J Pharm Anal. 2020 Aug;10(4):277-290. (PMID: 32923005)
Int J Antimicrob Agents. 2019 Jul;54(1):80-84. (PMID: 30930299)
Pharmaceuticals (Basel). 2021 Apr 19;14(4):. (PMID: 33921724)
Sci Rep. 2017 Apr 10;7:45723. (PMID: 28393840)
Molecules. 2019 Sep 23;24(19):. (PMID: 31547527)
Biomolecules. 2021 Mar 19;11(3):. (PMID: 33808721)
Sci Rep. 2020 Aug 6;10(1):13306. (PMID: 32764551)
Int J Med Microbiol. 2013 Aug;303(6-7):318-23. (PMID: 23499479)
Int J Pharm. 2020 Nov 15;589:119780. (PMID: 32860856)
Virol J. 2015 Dec 22;12:223. (PMID: 26695767)
Virology. 2016 Oct;497:157-162. (PMID: 27471954)
Eur J Med Chem. 2019 Dec 1;183:111708. (PMID: 31550659)
J Trop Med. 2019 Apr 2;2019:1895340. (PMID: 31065287)
PLoS One. 2014 Nov 19;9(11):e113527. (PMID: 25409171)
Sci Rep. 2020 Oct 6;10(1):16631. (PMID: 33024252)
Curr Drug Targets. 2021;22(5):555-572. (PMID: 32972338)
Chem Biol Interact. 2020 Nov 1;331:109218. (PMID: 32916141)
J Travel Med. 2020 Nov 9;27(7):. (PMID: 32941627)
Rev Inst Med Trop Sao Paulo. 2020 Dec 07;62:e97. (PMID: 33295481)
Antioxidants (Basel). 2019 Oct 16;8(10):. (PMID: 31623170)
Viruses. 2019 Nov 02;11(11):. (PMID: 31684080)
Planta Med. 2020 Dec;86(18):1363-1374. (PMID: 32937663)
Front Microbiol. 2017 Jul 11;8:1314. (PMID: 28744282)
Sci Rep. 2017 Mar 03;7:42717. (PMID: 28256516)
BMC Complement Med Ther. 2020 Aug 7;20(1):246. (PMID: 32767975)
Int J Mol Sci. 2019 Apr 15;20(8):. (PMID: 30991717)
Virology. 2016 Jun;493:217-26. (PMID: 27060565)
Sci Rep. 2018 Jul 18;8(1):10856. (PMID: 30022045)
J Mol Graph Model. 2016 Sep;69:78-91. (PMID: 27588363)
Evid Based Complement Alternat Med. 2013;2013:164215. (PMID: 23818919)
J Chem Inf Model. 2012 Feb 27;52(2):420-8. (PMID: 22196228)
J Chem Inf Comput Sci. 2004 May-Jun;44(3):1000-5. (PMID: 15154768)
Curr Med Chem. 2017;24(38):4279-4302. (PMID: 28814240)
Mar Drugs. 2019 Apr 18;17(4):. (PMID: 31003533)
Sci Rep. 2019 Nov 8;9(1):16348. (PMID: 31705028)
Virology. 2016 Sep;496:215-218. (PMID: 27344138)
Cell Host Microbe. 2016 May 11;19(5):696-704. (PMID: 27158114)
Crit Care. 2014 Aug 13;18(5):480. (PMID: 25405992)
Mol Ther. 2021 Feb 3;29(2):873-885. (PMID: 33333292)
Molecules. 2020 May 15;25(10):. (PMID: 32429073)
فهرسة مساهمة: Keywords: ADME; antimicrobial; antiviral; envelope protein; mangrove plants; pharmacokinetics
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Antifungal Agents)
0 (Antiviral Agents)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20211013 Date Completed: 20211117 Latest Revision: 20230921
رمز التحديث: 20230921
مُعرف محوري في PubMed: PMC8510246
DOI: 10.3390/molecules26195768
PMID: 34641314
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules26195768