Positronium imaging with the novel multiphoton PET scanner.

التفاصيل البيبلوغرافية
العنوان:	Positronium imaging with the novel multiphoton PET scanner.
المؤلفون:	Moskal P; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Dulski K; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Chug N; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Curceanu C; INFN, Laboratori Nazionali di Frascati, Frascati, Italy., Czerwiński E; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Dadgar M; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Gajewski J; Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland., Gajos A; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Grudzień G; Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Kraków, Poland., Hiesmayr BC; Faculty of Physics, University of Vienna, Vienna, Austria., Kacprzak K; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland., Kapłon Ł; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Karimi H; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Klimaszewski K; Department of Complex Systems, National Centre for Nuclear Research, Otwock-Świerk, Poland., Korcyl G; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland., Kowalski P; Department of Complex Systems, National Centre for Nuclear Research, Otwock-Świerk, Poland., Kozik T; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland., Krawczyk N; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Krzemień W; High Energy Physics Division, National Centre for Nuclear Research, Otwock-Świerk, Poland., Kubicz E; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Małczak P; 2nd Department of General Surgery, Jagiellonian University Medical College, Kraków, Poland., Niedźwiecki S; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Pawlik-Niedźwiecka M; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Pędziwiatr M; 2nd Department of General Surgery, Jagiellonian University Medical College, Kraków, Poland., Raczyński L; Department of Complex Systems, National Centre for Nuclear Research, Otwock-Świerk, Poland., Raj J; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Ruciński A; Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland., Sharma S; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Shivani; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Shopa RY; Department of Complex Systems, National Centre for Nuclear Research, Otwock-Świerk, Poland., Silarski M; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Skurzok M; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland., Stępień EŁ; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Szczepanek M; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Tayefi F; Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland., Wiślicki W; Department of Complex Systems, National Centre for Nuclear Research, Otwock-Świerk, Poland.
المصدر:	Science advances [Sci Adv] 2021 Oct 15; Vol. 7 (42), pp. eabh4394. Date of Electronic Publication: 2021 Oct 13.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: PubMed not MEDLINE; MEDLINE
أسماء مطبوعة:	Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
مستخلص:	In vivo assessment of cancer and precise location of altered tissues at initial stages of molecular disorders are important diagnostic challenges. Positronium is copiously formed in the free molecular spaces in the patient’s body during positron emission tomography (PET). The positronium properties vary according to the size of inter- and intramolecular voids and the concentration of molecules in them such as, e.g., molecular oxygen, O 2 ; therefore, positronium imaging may provide information about disease progression during the initial stages of molecular alterations. Current PET systems do not allow acquisition of positronium images. This study presents a new method that enables positronium imaging by simultaneous registration of annihilation photons and deexcitation photons from pharmaceuticals labeled with radionuclides. The first positronium imaging of a phantom built from cardiac myxoma and adipose tissue is demonstrated. It is anticipated that positronium imaging will substantially enhance the specificity of PET diagnostics.
تواريخ الأحداث:	Date Created: 20211013 Latest Revision: 20220302
رمز التحديث:	20221213
DOI:	10.1126/sciadv.abh4394
PMID:	34644101
قاعدة البيانات:	MEDLINE

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تدمد:	2375-2548
DOI:	10.1126/sciadv.abh4394