دورية أكاديمية
Evaluation of serum neuron specific enolase levels among patients with primary and secondary burning mouth syndrome.
| العنوان: | Evaluation of serum neuron specific enolase levels among patients with primary and secondary burning mouth syndrome. |
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| المؤلفون: | Kishore J; Department of Oral Pathology, 37093Ziauddin University, Ziauddin University, Karachi, Pakistan., Shaikh F; Department of Pathology, Ziauddin University, Karachi, Pakistan., Zubairi AM; Department of Pathology, Ziauddin University, Karachi, Pakistan., Mirza S; Department of Oral Pathology, 37093Ziauddin University, Ziauddin University, Karachi, Pakistan., Alqutub MN; Department of Periodontics and Community Dentistry, 37850King Saud University, 37850King Saud University, Riyadh, Saudi Arabia., AlMubarak AM; Department of Periodontics and Community Dentistry, 37850King Saud University, 37850King Saud University, Riyadh, Saudi Arabia., Abduljabbar T; Department of Prosthetic Dental Science, College of Dentistry, 37850King Saud University, Riyadh, Saudi Arabia., Vohra F; Department of Prosthetic Dental Science, College of Dentistry, 37850King Saud University, Riyadh, Saudi Arabia. |
| المصدر: | Cephalalgia : an international journal of headache [Cephalalgia] 2022 Feb; Vol. 42 (2), pp. 119-127. Date of Electronic Publication: 2021 Oct 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Country of Publication: England NLM ID: 8200710 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2982 (Electronic) Linking ISSN: 03331024 NLM ISO Abbreviation: Cephalalgia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2010- : London : Sage Original Publication: Oslo : Universitetsforlaget. |
| مواضيع طبية MeSH: | Burning Mouth Syndrome*/complications , Diabetes Mellitus*, Female ; Humans ; Menopause ; Phosphopyruvate Hydratase |
| مستخلص: | Introduction: Burning mouth syndrome is a painful condition of the oral cavity with ambiguous pathogenesis and diagnosis. Neuron-specific enolase is increased in several conditions including peripheral neuropathy of diabetes, ophthalmopathies, spinal cord injuries and tumors. Evidence on association of burning mouth syndrome and neuron-specific enolase is limited. Aim: This study aims to evaluate neuron-specific enolase levels in primary and secondary burning mouth syndrome patients and compare the levels of neuron-specific enolase with associated conditions in secondary burning mouth syndrome. Methods: One hundred and twenty-eight patients of more than 18 years of age with no gender predilection and having clinical symptoms of burning mouth syndrome and 135 healthy subjects were included. All the patients fulfilled Scala's criteria for the diagnosis of burning mouth syndrome, including "primary" (idiopathic) and "secondary" (resulting from identified precipitating factors) burning mouth syndrome patients. Blood samples were obtained from burning mouth syndrome patients. Serum neuron-specific enolase was evaluated using enzyme-linked immunosorbent assay. To compare means and standard deviations, among primary and secondary burning mouth syndrome, data was analysed with analysis of variance and multiple comparisons test. Results: The mean age of the study participants for burning mouth syndrome and healthy subjects was 53.30 and 51.6 years, respectively. Amongst the secondary burning mouth syndrome group, 32 (25%) of the patients had menopause, 15 (11.7%) had diabetes, eight (6.2%) of the patients had nutritional deficiency, seven (5.4%) had combined diabetes, menopause, and depression, six (4.6%) had combined diabetes and depression, four (3.1%) were diagnosed with Sjögren's syndrome. A minor percentage of 2.3% (three) had gastroesophageal reflux disease, while the remaining three (2.3%) patients in the secondary burning mouth syndrome group were on anti-depressants. There was a statistically significant increase in the levels of neuron-specific enolase in primary burning mouth syndrome as compared to the secondary burning mouth syndrome and healthy groups. Among the subgroups of secondary burning mouth syndrome, diabetic individuals showed a significant increase in neuron-specific enolase level when compared with other conditions in the secondary burning mouth syndrome patients.Discussion and conclusion: The raised serum neuron-specific enolase levels in patients suffering from primary burning mouth syndrome highlight a possible neuropathic mechanism. It was also increased in the sub-group of secondary burning mouth syndrome patients having diabetes. Although it cannot be ascertained whether the deranged values in the diabetic group were due to burning mouth syndrome or due to diabetes, the raised quantity of neuron-specific enolase in the primary burning mouth syndrome group is a reliable diagnostic indicator. Future studies on the assessment of neuron-specific enolase levels as a diagnostic tool for onset and management of primary and secondary burning mouth syndrome are recommended. |
| فهرسة مساهمة: | Keywords: Burning mouth syndrome; biomarker; diabetes; diagnosis; neuron-specific enolase; serum |
| المشرفين على المادة: | EC 4.2.1.11 (Phosphopyruvate Hydratase) |
| تواريخ الأحداث: | Date Created: 20211013 Date Completed: 20220505 Latest Revision: 20220505 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1177/03331024211046613 |
| PMID: | 34644195 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-2982 |
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| DOI: | 10.1177/03331024211046613 |