دورية أكاديمية
Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells.
| العنوان: | Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells. |
|---|---|
| المؤلفون: | Raina D; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany., Bahadori A; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany., Stanoev A; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany., Protzek M; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany., Koseska A; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany., Schröter C; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany. |
| المصدر: | Development (Cambridge, England) [Development] 2021 Nov 01; Vol. 148 (21). Date of Electronic Publication: 2021 Nov 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge Eng : Company Of Biologists Limited Original Publication: [Cambridge] : Company of Biologists, [c1987- |
| مواضيع طبية MeSH: | Cell Communication/*physiology , Cell Differentiation/*physiology , Fibroblast Growth Factor 4/*metabolism , Mouse Embryonic Stem Cells/*cytology, Animals ; Body Patterning ; Embryonic Development ; Endoderm/cytology ; Endoderm/embryology ; Endoderm/metabolism ; Fibroblast Growth Factor 4/genetics ; Germ Layers/cytology ; Germ Layers/embryology ; Germ Layers/metabolism ; Mice ; Mouse Embryonic Stem Cells/metabolism ; Paracrine Communication/physiology ; Signal Transduction |
| مستخلص: | During embryonic development and tissue homeostasis, reproducible proportions of differentiated cell types are specified from populations of multipotent precursor cells. Molecular mechanisms that enable both robust cell-type proportioning despite variable initial conditions in the precursor cells, and the re-establishment of these proportions upon perturbations in a developing tissue remain to be characterized. Here, we report that the differentiation of robust proportions of epiblast-like and primitive endoderm-like cells in mouse embryonic stem cell cultures emerges at the population level through cell-cell communication via a short-range fibroblast growth factor 4 (FGF4) signal. We characterize the molecular and dynamical properties of the communication mechanism and show how it controls both robust cell-type proportioning from a wide range of experimentally controlled initial conditions, as well as the autonomous re-establishment of these proportions following the isolation of one cell type. The generation and maintenance of reproducible proportions of discrete cell types is a new function for FGF signaling that might operate in a range of developing tissues. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2021. Published by The Company of Biologists Ltd.) |
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| فهرسة مساهمة: | Keywords: Dynamical system; Embryonic stem cells; Epiblast; FGF signaling; Mouse; Preimplantation development; Primitive endoderm |
| المشرفين على المادة: | 0 (Fgf4 protein, mouse) 0 (Fibroblast Growth Factor 4) |
| تواريخ الأحداث: | Date Created: 20211015 Date Completed: 20211216 Latest Revision: 20240404 |
| رمز التحديث: | 20240404 |
| مُعرف محوري في PubMed: | PMC8602943 |
| DOI: | 10.1242/dev.199926 |
| PMID: | 34651174 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1477-9129 |
|---|---|
| DOI: | 10.1242/dev.199926 |