دورية أكاديمية
أعرض في EDS

Helicobacter pylori genotypes associated with gastric cancer and dysplasia in Colombian patients.

التفاصيل البيبلوغرافية
العنوان: Helicobacter pylori genotypes associated with gastric cancer and dysplasia in Colombian patients.
المؤلفون: Carlosama-Rosero YH; Grupo Interdisciplinario de Investigación en Salud-Enfermedad, Universidad Cooperativa de Colombia, Pasto, Colombia. Electronic address: yeharca@hotmail.com., Acosta-Astaiza CP; Grupo de Investigación en Genética Humana y Aplicada, Universidad del Cauca, Popayán, Colombia., Sierra-Torres CH; Grupo de Investigación en Genética Humana y Aplicada, Universidad del Cauca, Popayán, Colombia., Bolaños-Bravo HJ; Grupo de Investigación en Genética Humana y Aplicada, Universidad del Cauca, Popayán, Colombia.
المصدر: Revista de gastroenterologia de Mexico (English) [Rev Gastroenterol Mex (Engl Ed)] 2022 Apr-Jun; Vol. 87 (2), pp. 181-187. Date of Electronic Publication: 2021 Oct 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Masson Doyma México, S.A Country of Publication: Mexico NLM ID: 101778603 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2255-534X (Electronic) Linking ISSN: 2255534X NLM ISO Abbreviation: Rev Gastroenterol Mex (Engl Ed) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [México] : Masson Doyma México, S.A
مواضيع طبية MeSH: Helicobacter Infections*/complications , Helicobacter Infections*/epidemiology , Helicobacter Infections*/pathology , Helicobacter pylori*/genetics , Stomach Neoplasms*/complications , Stomach Neoplasms*/epidemiology, Antigens, Bacterial/genetics ; Bacterial Proteins/genetics ; Case-Control Studies ; Colombia/epidemiology ; Genotype ; Humans ; Middle Aged
مستخلص: Introduction and Aims: Colombia has high incidence levels of gastric cancer that can be explained by the genetic variability of Helicobacter pylori (H. pylori). Our aim was to establish the relation of the H. pylori CagA and VacA genotypes to dysplasia and gastric cancer, in a high-risk population.
Material and Methods: A case-control study was conducted on 202 patients from a high-risk cancer zone. Patients with dysplasia and gastric cancer (cases) and patients with nonatrophic gastritis (controls) were included. Endoscopic sampling and histologic classification were carried out according to the Sydney system and the Lauren classification. Genetic information was obtained through polymerase chain reaction on paraffin blocks. The measures of association of the variables of interest were evaluated in bivariate and multivariate models. A P<0.05 was considered statistically significant and the SPSS version 25 program was employed.
Results: Age above 50 years (OR: 23.76; CI: 8.40-67.17; P=0.000) and the VacA s1m1 genotype (OR: 6.18; CI: 1.25-30.51; P=0.025) were associated with higher risk for developing dysplasia and gastric cancer. The CagA+ genotype was not found to be a risk factor for developing those pathologies (OR: 1.02; CI: 0.39-2.62; P=0.965).
Conclusions: The H. pylori VacA genotypes are markers for the development of gastric cancer. That information could be used to create a risk index in a predictive model to optimize the healthcare of higher-risk patients.
(Copyright © 2021 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A. All rights reserved.)
فهرسة مساهمة: Keywords: CagA; Cáncer gástrico; Gastric cancer; Genotipos; Genotypes; Helicobacter pylori; VacA
المشرفين على المادة: 0 (Antigens, Bacterial)
0 (Bacterial Proteins)
تواريخ الأحداث: Date Created: 20211017 Date Completed: 20220609 Latest Revision: 20220609
رمز التحديث: 20221213
DOI: 10.1016/j.rgmxen.2021.09.003
PMID: 34656500
قاعدة البيانات: MEDLINE
الوصف
تدمد:2255-534X
DOI:10.1016/j.rgmxen.2021.09.003