دورية أكاديمية
Are Reduced Levels of Coagulation Proteins Upon Admission Linked to COVID-19 Severity and Mortality?
| العنوان: | Are Reduced Levels of Coagulation Proteins Upon Admission Linked to COVID-19 Severity and Mortality? |
|---|---|
| المؤلفون: | Ceballos FC; Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Madrid, Spain., Ryan P; Department of Infectious Diseases, Hospital Universitario Infanta Leonor, Madrid, Spain., Blancas R; Critical Care Department, Hospital Universitario del Tajo, Aranjuez, Spain., Martin-Vicente M; Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Madrid, Spain., Vidal-Alcántara EJ; Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Madrid, Spain., Peréz-García F; Clinical Microbiology Department, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain., Bartolomé S; Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Madrid, Spain., Churruca-Sarasqueta J; Haematology and Haemostasis Department, University Hospital Infanta Leonor, Madrid, Spain., Virseda-Berdices A; Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Madrid, Spain., Martínez-González O; Critical Care Department, Hospital Universitario del Tajo, Aranjuez, Spain., Brochado-Kith O; Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Madrid, Spain., Rava M; Unit AIDS Research Network Cohort (CoRIS), National Center of Epidemiology (CNE), Health Institute Carlos III (ISCIII), Madrid, Spain., Vilches-Medkouri C; Clinical Analysis Service, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain., Blanca-López N; Allergology Department, University Hospital Infanta Leonor, Madrid, Spain., Ramirez Martinez-Acitores I; Critical Care Department, Hospital Universitario del Tajo, Aranjuez, Spain., Moreira-Escriche P; Department of Infectious Diseases, Hospital Universitario Severo Ochoa, Madrid, Spain., De Juan C; Department of Infectious Diseases, Hospital Universitario Severo Ochoa, Madrid, Spain., Resino S; Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Madrid, Spain., Fernández-Rodríguez A; Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Madrid, Spain., Jiménez-Sousa MÁ; Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Madrid, Spain. |
| المصدر: | Frontiers in medicine [Front Med (Lausanne)] 2021 Sep 30; Vol. 8, pp. 718053. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]- |
| مستخلص: | Background: The link between coagulation system disorders and COVID-19 has not yet been fully elucidated. Aim: Evaluating the association of non-previously reported coagulation proteins with COVID-19 severity and mortality. Design: Cross-sectional study of 134 COVID-19 patients recruited at admission and classified according to the highest COVID-19 severity reached (asymptomatic/mild, moderate, or severe) and 16 healthy control individuals. Methods: Coagulation proteins levels (antithrombin, prothrombin, factor_XI, factor_XII, and factor_XIII) and CRP were measured in plasma by the ProcartaPlex Panel (Invitrogen) multiplex immunoassay upon diagnosis. Results: We found higher levels of antithrombin, prothrombin, factor XI, factor XII, and factor XIII in asymptomatic/mild and moderate COVID-19 patients compared to healthy individuals. Interestingly, decreased levels of antithrombin and factors XI, XII, and XIII were observed in those patients who eventually developed severe illness. Additionally, survival models showed us that patients with lower levels of these coagulation proteins had an increased risk of death. Conclusion: COVID-19 provokes early increments of some specific coagulation proteins in most patients. However, lower levels of these proteins at diagnosis might "paradoxically" imply a higher risk of progression to severe disease and COVID-19-related mortality. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Ceballos, Ryan, Blancas, Martin-Vicente, Vidal-Alcántara, Peréz-García, Bartolomé, Churruca-Sarasqueta, Virseda-Berdices, Martínez-González, Brochado-Kith, Rava, Vilches-Medkouri, Blanca-López, Ramirez Martinez-Acitores, Moreira-Escriche, De Juan, Resino, Fernández-Rodríguez and Jiménez-Sousa.) |
| References: | J Med Virol. 2021 Feb;93(2):934-944. (PMID: 32706426) Am J Hematol. 2020 Dec;95(12):1522-1530. (PMID: 32833259) J Am Heart Assoc. 2021 Feb 2;10(3):e019650. (PMID: 33228447) JAMA. 2020 Aug 25;324(8):799-801. (PMID: 32702090) Nat Commun. 2020 Nov 12;11(1):5749. (PMID: 33184277) Medicine (Baltimore). 2021 Feb 19;100(7):e24537. (PMID: 33607784) Intensive Care Med. 2020 Jun;46(6):1089-1098. (PMID: 32367170) Thromb Res. 2021 Mar;199:132-142. (PMID: 33503547) Res Pract Thromb Haemost. 2017 Dec 21;2(1):85-92. (PMID: 30046710) Int J Hematol. 2021 Jan;113(1):45-57. (PMID: 33161508) Ann Hematol. 2021 Feb;100(2):309-320. (PMID: 33415422) Circulation. 2020 Jul 14;142(2):184-186. (PMID: 32330083) Blood Rev. 2021 May;47:100761. (PMID: 33067035) Blood Rev. 2021 Mar;46:100745. (PMID: 32868115) Inflamm Res. 2020 Dec;69(12):1181-1189. (PMID: 32918567) J Thromb Haemost. 2020 Jun;18(6):1324-1329. (PMID: 32306492) J Thromb Haemost. 2020 Apr;18(4):844-847. (PMID: 32073213) BMJ. 2020 May 21;369:m2058. (PMID: 32439704) Intern Emerg Med. 2021 Mar;16(2):309-312. (PMID: 33368021) J Biomed Inform. 2019 Jul;95:103208. (PMID: 31078660) Nat Rev Cardiol. 2021 Mar;18(3):194-209. (PMID: 33214651) Eur J Haematol. 2020 Dec;105(6):741-750. (PMID: 32749010) Cell Syst. 2021 Jan 20;12(1):23-40.e7. (PMID: 33096026) |
| فهرسة مساهمة: | Keywords: COVID-19; SARS; SARS-CoV-2; coagulation factors; mortality |
| تواريخ الأحداث: | Date Created: 20211018 Latest Revision: 20211022 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8514618 |
| DOI: | 10.3389/fmed.2021.718053 |
| PMID: | 34660629 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-858X |
|---|---|
| DOI: | 10.3389/fmed.2021.718053 |