دورية أكاديمية
Preliminary Correlation of the Immunoexpression of Cathepsin B and E-Cadherin Proteins in Vocal Fold Leukoplakia.
| العنوان: | Preliminary Correlation of the Immunoexpression of Cathepsin B and E-Cadherin Proteins in Vocal Fold Leukoplakia. |
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| المؤلفون: | Filho FSA; Department of Otolaryngology, Head and Neck Surgery of the Federal University of São Paulo, Paulista School of Medicine, São Paulo, Brazil., Santiago LH; Department of pathology, ABC Medical School, State of São Paulo, Brazil., Fernandes ACN; Laboratório de Ensino e Pesquisa em Otorrinolaringologia, Faculdade de Medicina, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília/DF, Brazil. Electronic address: fga.carolinafernandes@gmail.com., Korn GP; Department of Otolaryngology and Head, Neck Surgery of the Federal University of São Paulo, Paulista School of Medicine, São Paulo, Brazil., Pontes PAL; Department of Otolaryngology, Head and Neck Surgery of the Federal University of São Paulo, Paulista Medical School, São Paulo, Brazil., Camponês do Brasil OO; Department of Otolaryngology, Head and Neck Surgery of the Federal University of São Paulo, Paulista School of Medicine, São Paulo, Brazil. |
| المصدر: | Journal of voice : official journal of the Voice Foundation [J Voice] 2024 May; Vol. 38 (3), pp. 760-767. Date of Electronic Publication: 2021 Oct 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 8712262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4588 (Electronic) Linking ISSN: 08921997 NLM ISO Abbreviation: J Voice Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : St. Louis, MO : Mosby Original Publication: [New York, N.Y.] : Raven Press, 1987- |
| مواضيع طبية MeSH: | Antigens, CD*/analysis , Cadherins*/genetics , Cadherins*/metabolism , Cathepsin B*/genetics , Cathepsin B*/metabolism , Leukoplakia*/pathology , Leukoplakia*/surgery , Vocal Cords*/pathology , Vocal Cords*/metabolism , Vocal Cords*/surgery, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Alcohol Drinking/adverse effects ; Biomarkers, Tumor ; Immunohistochemistry ; Retrospective Studies ; Risk Factors ; Smoking/adverse effects |
| مستخلص: | Objectives: Early identification of vocal fold leukoplakia (VFL), which has a risk of progressing to malignant transformation, remains a controversial topic. The identification of biological markers for diagnosing these lesions would lead to a more effective treatment. We aimed to analyze the immunoexpression of cathepsin B and E-cadherin in VFL and correlate it with clinical and epidemiological data and disease prognosis. Methods: Thirty-two patients with VFL treated with microsurgery were retrospectively evaluated. The patients were distributed according to the histological results into Group A (low grade) and Group B (high grade). The expression of markers was quantitatively determined as per their staining intensity and tissue distribution using ImageLab. The index of expression (IE) of each marker was correlated with tobacco and alcohol consumption, signs of laryngopharyngeal reflux, and local recurrence of the lesion. Results: The correlation between the IE of markers and variables within the two groups (A and B) demonstrated that patients in Group B with local recurrence had a higher IE of cathepsin B. When all patients (A + B) were included, the same analysis demonstrated that the IE of cathepsin B was higher among smokers and patients who did not show signs of reflux and that the IE of E-cadherin was higher only in patients with recurrence. Conclusion: Patients with moderate to severe dysplasia and carcinoma in situ who smoked as well as had a high IE of cathepsin B were more prone to local recurrence. Regardless of the type of histological lesion, patients with signs of laryngopharyngeal reflux had a lower IE of cathepsin B. The IE of E-cadherin was higher among patients with VFL who relapsed after initial treatment. (Copyright © 2021 The Voice Foundation. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Larynx—Reflux—Early glottic cancer—Laryngology |
| المشرفين على المادة: | 0 (CDH1 protein, human) 0 (CTSB protein, human) |
| تواريخ الأحداث: | Date Created: 20211019 Date Completed: 20240428 Latest Revision: 20240522 |
| رمز التحديث: | 20240522 |
| DOI: | 10.1016/j.jvoice.2021.08.005 |
| PMID: | 34663533 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-4588 |
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| DOI: | 10.1016/j.jvoice.2021.08.005 |