دورية أكاديمية
أعرض في EDS

Supplementation of omega-3 and dietary factors can influence the cholesterolemia and triglyceridemia in hyperlipidemic Schnauzer dogs: A preliminary report.

التفاصيل البيبلوغرافية
العنوان: Supplementation of omega-3 and dietary factors can influence the cholesterolemia and triglyceridemia in hyperlipidemic Schnauzer dogs: A preliminary report.
المؤلفون: de Albuquerque P; Universidade de Santo Amaro, São Paulo, Brazil., De Marco V; Universidade de Santo Amaro, São Paulo, Brazil.; Faculdade de Medicina Veterinária e Zootecnia, Centro de Pesquisa em Nutrologia de Cães e Gatos, Universidade de São Paulo, Sao Paulo, SP, Brazil., Vendramini THA; Faculdade de Medicina, Laboratorio de Lipides (LIM-10), Hospital das Clinicas HCFMUSP, Universidade de São Paulo, Sao Paulo, SP, Brazil., Amaral AR; Faculdade de Medicina, Laboratorio de Lipides (LIM-10), Hospital das Clinicas HCFMUSP, Universidade de São Paulo, Sao Paulo, SP, Brazil., Catanozi S; Naya Especialidades, São Paulo, SP, Brazil., Santana KG; Naya Especialidades, São Paulo, SP, Brazil., Nunes VS; Naya Especialidades, São Paulo, SP, Brazil., Nakandakare ER; Naya Especialidades, São Paulo, SP, Brazil., Brunetto MA; Faculdade de Medicina, Laboratorio de Lipides (LIM-10), Hospital das Clinicas HCFMUSP, Universidade de São Paulo, Sao Paulo, SP, Brazil.
المصدر: PloS one [PLoS One] 2021 Oct 19; Vol. 16 (10), pp. e0258058. Date of Electronic Publication: 2021 Oct 19 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Metabolic Diseases*/drug therapy , Metabolic Diseases*/veterinary, Cholesterol/*blood , Dog Diseases/*drug therapy , Fatty Acids, Omega-3/*administration & dosage , Lipoproteins/*blood , Triglycerides/*blood, Animals ; Dogs ; Female ; Male
مستخلص: Primary hyperlipidaemia in Schnauzer is characterized by increased plasma triglycerides (TG) and/or total cholesterol (TC) concentration and is associated with an increased risk of developing pancreatitis, insulin resistance and seizures. In humans, omega-3 fatty acids in addition to a low-fat diet can be used to reduce TG and TC. This study evaluated the therapeutic efficacy of omega-3 fatty acids associated to a diet management with two different fat content in Schnauzer with primary hyperlipidaemia. Eighteen dogs with primary hyperlipidaemia were divided into two groups: group 1, n = 10, 8 females, 2 males, age (mean ± standard deviation) of 7.13 ± 2.70 years and body weight (BW) (mean ± standard deviation) of 7.25 ± 1.22 kg were treated with fish oil (approximately 730 mg/day of omega-3) associated with a low-fat and low-calorie diet (approximately 24g of fat/1000 kcal) for 90 days (T90); and group 2, n = 8 dogs, 6 females, 2 males, with 7.0 ± 1.77 years old and average BW of 8.36 ± 1.51 kg, treated with fish oil (approximately 730 mg/day of omega-3) and maintenance diet with moderate amount of fat (approximately 33g of fat/1000 kcal) for 90 days. Plasma TG and TC concentrations and lipoprotein (LP) profile (VLDL, LDL, HDL) were evaluated before and after treatment. TG and TC serum concentrations, expressed in mg/dL (mean ± standard deviation), before and after treatment in group 1 were: TG = 391.30 ± 487.86 (T0) and 118.7 ± 135.21 (T90); TC = 308.2 ± 63.06 (T0) and 139 ± 36.91 (T90). As for group 2, TG = 391.63 ± 336.89 (T0) and 250.75 ± 211.56 (T90); TC = 257.25 ± 92.88 (T0) and 207.25 ± 63.79 (T90). A reduction (p<0.05) of TG and TC was observed in both groups. The distribution of TG and TC among LP was not different between the pre (T0) and post treatment (T90) periods. After 90 days of treatment, the administration of omega-3 fatty acids, associated with a low-fat or maintenance diet reduced triglyceridemia and cholesterolemia without altering LP profile. The current investigation shows that both therapies were effective in reducing plasma TC and TG concentrations without altering LP profile.
Competing Interests: The funder [Avert and Archer Daniels Midland Company (ADM)] provided support in the form of products and food for carrying out the study, however, this does not alter our adherence to PLOS ONE policies on sharing data and materials. The authors have declared that no competing interests exist.
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المشرفين على المادة: 0 (Fatty Acids, Omega-3)
0 (Lipoproteins)
0 (Triglycerides)
97C5T2UQ7J (Cholesterol)
تواريخ الأحداث: Date Created: 20211019 Date Completed: 20211129 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC8525743
DOI: 10.1371/journal.pone.0258058
PMID: 34665804
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0258058